Comparison between Widefield En Face Swept-Source OCT and Conventional Multimodal Imaging for the Detection of Reticular Pseudodrusen

Schaal, Karen B.; Legarreta, Andrew D.; Feuer, William J.; Gregori, Giovanni; Cheng, Qianqian Ellie; Legarreta, John E.; Durbin, Mary K; Stetson, Paul F.; Kubach, Sophie; Rosenfeld, Philip J.

doi:10.1016/j.ophtha.2016.10.009

Cited by 21 publications

(8 citation statements)

References 40 publications

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“…At corresponding locations on a retinal pigment epithelium slab, darker areas of reduced reflectivity can be seen . Comparison between using en face optical coherence tomography imaging alone and conventional multimodal imaging for identification of RPD, demonstrated no difference in detection rates …”

Section: Appearance On Imagingmentioning

confidence: 99%

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Reticular pseudodrusen: current understanding

Wightman

Guymer

2019

Clinical and Experimental Optometry

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Reticular pseudodrusen (RPD), also known as subretinal drusenoid deposits, represent a morphological change to the retina distinct from other subtypes of drusen by being located above the level of the retinal pigment epithelium. Although they can infrequently appear in individuals with no other apparent pathology, their highest rates of occurrence are in association with age-related macular degeneration (AMD), for which they hold clinical significance by being highly correlated with end-stage disease sub-types, choroidal neovascularisation and geographic atrophy. Reticular pseudodrusen are also found in other diseases, most notably Sorsby's fundus dystrophy, pseudoxanthoma elasticum and acquired vitelliform lesions. They are found more frequently in females, with increased age and more commonly bilaterally than unilaterally. Increased risk of RPD formation is conveyed by genetic variants known to increase risk of AMD development, including complement factor H, age-related maculopathy susceptibility 2, and high-temperature requirement A serine peptidase 1; however, to date, no genetic factor has been found to predispose to RPD independent of those that carry risks for AMD. They have typical features visible on multimodal imaging, identifiable either as single lesions or more commonly in yellowishwhite net-like patterns on colour fundus photography and are particularly distinguishable using spectral domain optical coherence tomography, fundus auto-fluorescence, and near infrared reflectance imaging. On histological examination, RPD have been shown to have distinct compositions in comparison to typical drusen, suggesting different pathways of pathogenesis. Although their aetiology remains unclear, presence of opsin within lesions, a high topographic association with areas of highest rod-photoreceptor concentration and functional deficits most pronounced within the scotopic range, has implicated rod photoreceptor dysfunction as a component of RPD.

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Section: Appearance On Imagingmentioning

confidence: 99%

“…En face optical coherence tomography produces transverse views of the retina and choroid at specified depths . RPD are distinctly discernible using this modality and on the ellipsoid zone slab appear as small round lesions with bright hyper‐reflective centres and darker edges .…”

Section: Appearance On Imagingmentioning

confidence: 99%

Reticular pseudodrusen: current understanding

Wightman

Guymer

2019

Clinical and Experimental Optometry

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“…Multimodal imaging studies revealed that IR, FAF, SD-OCT and widefield en face SS-OCT have the highest sensitivity in detecting RPD, whereas late phases of ICGA, blue channel of CFP and confocal blue reflectance (CBR) have almost perfect specificity. 14 , 18 , 64 However, there is no real gold standard for PRD detection, and use of at least 2 imaging modalities has been advocated. 65 It has been suggested to use a high sensible modality (ie, SD-OCT, IR) as a screening test and a high specific one (ie, ICGA, CFP, CBR) as confirmation.…”

Section: Introductionmentioning

confidence: 99%

“…SD-OCT has excellent diagnostic properties and reliability in identification of RPD. 18 Schaal et al 64 , 92 demonstrated that en face OCT can image RPD, and this methodology alone has similar diagnostic abilities of conventional multimodal imaging (ie, CFP, IR and FAF). Polarization-sensitive (PS)-OCT is able to provide more contrast for structures, such as RPE, that are able to alter the polarization state of the light.…”

Section: Introductionmentioning

confidence: 99%

Spotlight on reticular pseudodrusen

Rabiolo

Sacconi

Cicinelli

et al. 2017

OPTH

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Age-related macular degeneration (AMD) is a leading cause of vision loss in patients >50 years old. The hallmark of the disease is represented by the accumulation of extracellular material between retinal pigment epithelium and the inner collagenous layer of Bruch’s membrane, called drusen. Although identified almost 30 years ago, reticular pseudodrusen (RPD) have been recently recognized as a distinctive phenotype. Unlike drusen, they are located in the subretinal space. RPD are strongly associated with late AMD, especially geographic atrophy, type 2 and 3 choroidal neovascularization, which, in turn, are less common in typical AMD. RPD identification is not straightforward at fundus examination, and their identification should employ at least 2 different imaging modalities. In this narrative review, we embrace all aspects of RPD, including history, epidemiology, histology, imaging, functional test, natural history and therapy.

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“…The inner slab detects subretinal drusenoid deposits, while the outer slab detects soft drusen and cuticular drusen. The challenging type of subretinal drusenoid deposits had been detected by multi-modal methods previously [58][59][60][61], but detection by OCT alone had not been previously demonstrated. The method exhibits good detection accuracy and repeatability.…”

Section: Discussionmentioning

confidence: 99%

Automated drusen detection in dry age-related macular degeneration by multiple-depth, en face optical coherence tomography

Zhao¹,

Camino²,

Wang³

et al. 2017

Biomed. Opt. Express

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We introduce a method to automatically detect drusen in dry age-related macular degeneration (AMD) from optical coherence tomography with minimum need for layer segmentation. The method is based on the detection of drusen areas in C-scans at certain distances above the Bruch's membrane, circumventing the difficult task of pathologic retinal pigment epithelium segmentation. All types of drusen can be detected, including the challenging subretinal drusenoid deposits (pseudodrusen). The high sensitivity and accuracy demonstrated here shows its potential for detection of drusen onset in early AMD.

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Comparison between Widefield En Face Swept-Source OCT and Conventional Multimodal Imaging for the Detection of Reticular Pseudodrusen

Cited by 21 publications

References 40 publications

Reticular pseudodrusen: current understanding

Reticular pseudodrusen: current understanding

Spotlight on reticular pseudodrusen

Automated drusen detection in dry age-related macular degeneration by multiple-depth, en face optical coherence tomography

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