Comparison Distribution of HLA-B Alleles in Mexican Patients with Takayasu Arteritis and Tuberculosis

HLA profile in patients with AIDS and tuberculosis

“…Also, in an investigation of class I HLA subtypes, Soto et al (2007) [10], in a study on Mexican patients, demonstrated an association of HLA-B35 with pulmonary tuberculosis and of HLA B39 and HLA B40 with extrapulmonary tuberculosis, and Pospelov et al (2007) [9], in a study of Russian patients, detected a positive association of HLA-B27 antigen with tuberculosis.…”

“…In addition, there is a relation between the immunological response and the HLA profile of an individual, which results in greater or lesser genetic susceptibility to certain infections, such as tuberculosis [2][3][4][5][6][7][8][9][10].…”

Takayasu’s Arteritis and Its Potential Pathogenic Association with Mycobacterium tuberculosis

“…Specifically, alleles HLA-B52, DRB1*1502, DRB5*0102, DQA1*0103, DQB1*0601 as well as the extended haplotype HLABw52-DRB1*1502-DRB5*0102-DQA1*0103-DQB1*0601 -DPA1*02-DPB1*0901 may confer susceptibility to Takayasu's arteritis in Japanese patients; whereas the combination HLABw54-DRB1*0405-DRB4*0101-DQA1*0301-DQB1*0401 seems to confer resistance (Dong et al, 1992). While, studies based on Mexican cohorts show that Takayasu's arteritis is associated with higher frequencies of alleles HLA-B39, -B52, and -B39 class I molecules, as well as allele HLA-DRB1*1301 class II molecule (Girona et al, 1996;Soto et al, 2007;VargasAlarcón et al, 2008). In Indian patients, an association with alleles HLA-B5 and -B21 has been described (Rose et al, 1991).…”

“…While, it may support a biological plausibility to PPD delayed-type hypersensitivity intradermal reactions commonly seen in both diseases. Unfortunately, available results from few studies focused on HLA-B alleles do not support this attractive thesis (Soto et al, 2007;Vargas-Alarcón et al, 2008). Alternatively, there is a group of innate immune molecules whose genes are located near the HLA-B gene region; these molecules are termed MHC class I chain-related A (MIC-A) and may have a crucial role in the pathogenesis of Takayasu's arteritis.…”

“…Of note, BCG vaccination is routinely administrated at birth in Mexico. Recently, it was showed that skin delayed hypersensitivity to PPD with induration over 10 mm may be as frequent (92.5% versus 89%) in Takayasu's arteritis as in patients with extra-pulmonary tuberculosis (Soto et al, 2007). Higher frequencies of positive tuberculin tests in Takayasu's patients than in general population also are described in series from Japan (85-92% versus 0.3%) and Korea (90% versus 4.2%) (Ueda et al, 1968& Keun-Soo et al, 1967, as cited in Pantell & Goodman, 1981.…”