Comparison of 18F-FDG PET/CT and 68Ga-DOTATATE PET/CT Imaging in Metastasized Merkel Cell Carcinoma

Epstude, Maximilian; Tornquist, Katharina; Riklin, Christian; Lenardo, Francesca di; Winterhalder, Ralph; Hug, Urs; Strobel, Klaus

doi:10.1097/rlu.0b013e318281658e

Cited by 37 publications

(24 citation statements)

References 8 publications

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“…In the largest series evaluating 20 patients with MCC, 111 indium-octreotide scintigraphy demonstrated a sensitivity of 78 and a specificity of 95%. However, PET/CT imaging with 68 gallium-labelled somatostatin analogues ( 68 Ga-DOTATOC, 68 Ga-DOTATATE) has greater detection efficacy in NETs [54], and recent studies have suggested its accuracy in MCC staging [18,22]. The lack of sensitivity of conventional SRI in MCC patients may be related to the heterogeneity of individual SSTR expression, as evidenced by immunohistochemistry in our study.…”

Section: Discussionmentioning

confidence: 38%

“…This is supported by the ability of SRI to detect MCCs and their metastases [17,18,19,20,21,22] as well as some cases of tumoural response to somatostatin analogues [23,24,25,26,27,28]. However, the efficacy of SSTR-targeted imaging and therapy in MCC patients is not uniform, suggesting that the in situ expression of SSTRs in MCCs may be heterogeneous.…”

Section: Introductionmentioning

confidence: 94%

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Somatostatin Receptors 2A and 5 Are Expressed in Merkel Cell Carcinoma with No Association with Disease Severity

Gardair¹,

Samimi

Touzé

et al. 2015

Neuroendocrinology

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Background/Aims: Merkel cell carcinoma (MCC) is a rare high-grade neuroendocrine tumour of the skin. It has been speculated that MCCs express somatostatin receptors (SSTRs), but this has never been assessed in a large series of MCCs. The main aim of this study was to assess the expression of SSTR2A and SSTR5 in MCC tumours. The secondary aims were to assess whether expression of SSTR was associated with the Ki67 proliferative index, Merkel cell polyomavirus (MCPyV) status, clinical characteristics and outcome. Methods: Clinical data and tumours were collected from an ongoing cohort of French patients with MCC. Immunohistochemistry was performed with anti-SSTR2A and anti-SSTR5 monoclonal antibodies, and tumours were classified into 3 groups: ‘no expression', ‘low expression' and ‘moderate expression' using an SSTR staining score. Results: SSTR expression was assessed for 105 MCC tissue samples from 98 patients, and clinical characteristics were available for 87 of them. SSTR expression was consistent between the primary skin tumour and the corresponding metastases for SSTR2A and SSTR5 in 3/7 and 6/7 cases, respectively. SSTR2A and SSTR5 were expressed in 58 cases (59.2%) and in 44 cases (44.9%), respectively. Overall, at least one SSTR was expressed in 75 tumours (76.5%). SSTR expression was not associated with clinical characteristics, Ki67 proliferative index, recurrence-free survival or MCC-specific survival. Expression of SSTR2A was associated with MCPyV status in MCC tumours but not SSTR5. Conclusion: SSTRs were expressed in a high proportion of MCCs, although expression was heterogeneous between tumours and was not associated with disease severity.

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Section: Discussionmentioning

confidence: 38%

Section: Introductionmentioning

confidence: 94%

Somatostatin Receptors 2A and 5 Are Expressed in Merkel Cell Carcinoma with No Association with Disease Severity

Gardair¹,

Samimi

Touzé

et al. 2015

Neuroendocrinology

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“…SLNB can be spared. SSTR-PET may have higher diagnostic performance than FDG-PET in MCC as pointed out in a recent case report [24]. In a retrospective analysis, FDG-PET/(CT) has been shown to be a useful tool in management of MCC and may lead to upstaging of 16% of patients [14].…”

Section: Discussionmentioning

confidence: 99%

“…SSTR-PET is more sensitive and accurate for tumor detection than respective scintigraphic techniques [22]. SSTR-PET has been claimed to be beneficial compared to conventional imaging and FDG-PET in selected patients with MCC [23,24]. …”

Section: Introductionmentioning

confidence: 99%

Somatostatin receptor expression in Merkel cell carcinoma as target for molecular imaging

et al. 2014

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BackgroundMerkel cell carcinoma (MCC) is a rare cutaneous neoplasm with increasing incidence, aggressive behavior and poor prognosis. Somatostatin receptors (SSTR) are expressed in MCC and represent a potential target for both imaging and treatment.MethodsTo non-invasively assess SSTR expression in MCC using PET and the radiotracers [68Ga]DOTA-D-Phe1-Tyr3-octreotide (DOTATOC) or -octreotate (DOTATATE) as surrogate for tumor burden. In 24 patients with histologically proven MCC SSTR-PET was performed and compared to results of computed tomography (CT).ResultsSSTR-PET detected primary and metastatic MCC lesions. On a patient-based analysis, sensitivity of SSTR-PET was 73% for nodal metastases, 100% for bone, and 67% for soft-tissue metastases, respectively. Notably, brain metastases were initially detected by SSTR-PET in 2 patients, whereas liver and lung metastases were diagnosed exclusively by CT. SSTR-PET showed concordance to CT results in 20 out of 24 patients. Four patients (17%) were up-staged due to SSTR-PET and patient management was changed in 3 patients (13%).ConclusionSSTR-PET showed high sensitivity for imaging bone, soft tissue and brain metastases, and particularly in combination with CT had a significant impact on clinical stage and patient management.

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“…Preliminary case reports have indicated that 67 Ga-DOTATATE can localize well in MCC, with one case showing better localization than FDG [22,24,25]. In order to determine if there is any role for these new 68 Ga PET tracers additional studies need to be performed evaluating their utility in MCC.…”

Section: Molecular Imaging and Therapy Of Merkel Cell Carcinomamentioning

confidence: 99%

Molecular Imaging and Therapy of Merkel Cell Carcinoma

Beylergil

Carrasquillo

2014

Cancers

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Comparison of 18F-FDG PET/CT and 68Ga-DOTATATE PET/CT Imaging in Metastasized Merkel Cell Carcinoma

Cited by 37 publications

References 8 publications

Somatostatin Receptors 2A and 5 Are Expressed in Merkel Cell Carcinoma with No Association with Disease Severity

Somatostatin Receptors 2A and 5 Are Expressed in Merkel Cell Carcinoma with No Association with Disease Severity

Somatostatin receptor expression in Merkel cell carcinoma as target for molecular imaging

Molecular Imaging and Therapy of Merkel Cell Carcinoma

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