Comparison of 18F-NaF PET/CT with Other Imaging Methods in the Detection of Bone Metastases in Patients with Medullary Thyroid Cancer: a Report of a Series of 31 Cases

Ueda, Cristiane; Duarte, Paulo Schiavom; Castroneves, Luciana A.; Coura-Filho, George Barberio; Sado, Heitor Naoki; Sapienza, Marcelo Tatit; Hoff, Ana O.; Buchpiguel, Carlos Alberto

doi:10.1007/s13139-020-00666-3

Cited by 14 publications

(8 citation statements)

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“…Previous PET/CT studies have demonstrated that 18 F-NaF can detect bone metastases ( 2 , 15 ) and sporadic extraosseous metastases ( 1 , 6 ) of MTC, sometimes with greater accuracy than 68 Ga-labeled somatostatin analogues ( 2 , 16 ). The underlying mechanism of 18 F-NaF uptake by MTC extraosseous metastases is not fully understood but is believed to be due to the progressive calcification of amyloid deposits that frequently occur in these tumors ( 4 ).…”

Section: Discussionmentioning

confidence: 99%

Correlation of 18F-sodium fluoride uptake and radiodensity in extraosseous metastases of medullary thyroid carcinoma

Ueda,

Dias,

Carneiro

et al. 2024

Archives of Endocrinology and Metabolism

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Objective: Although 18 F-sodium fluoride ( 18 F-NaF) uptake is frequently observed in extraosseous metastases of medullary thyroid carcinoma (MTC) with calcification, it can also occur in metastatic sites without visible calcium deposition, leading to the hypothesis that visually undetectable calcium accumulation may be responsible for this uptake. The aim of this study was to indirectly support this hypothesis by analyzing the correlation between the degree of 18 F-NaF uptake and radiodensity in extraosseous MTC metastases, since calcium deposition can increase attenuation even when not visually detectable. Subjects and methods: Extraosseous metastatic lesions of 15 patients with MTC were evaluated using 18 F-NaF positron-emission tomography (PET)/computed tomography (CT) and segmented by levels of standardized uptake value (SUV). The correlation between mean SUV and mean Hounsfield unit (HU) values was assessed for the entire group of segments and for two subgroups with different mean HU values. Results: Very high correlations were observed between mean SUV and mean HU values for both the entire group of segments and the subgroup with a mean HU value greater than 130 (p = 0.92 and p = 0.95, respectively; p < 0.01). High correlation ( p = 0.71) was also observed in the subgroup with mean HU values ranging from 20 to 130 (p < 0.01). Conclusion: The findings of the present study suggest that there is an association between 18 F-NaF uptake and calcium deposition in extraosseous metastases of MTC, supporting the hypothesis that visually undetectable calcium accumulation may be responsible for 18 F-NaF uptake in regions without visible calcium deposition.

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Section: Discussionmentioning

confidence: 99%

Correlation of 18F-sodium fluoride uptake and radiodensity in extraosseous metastases of medullary thyroid carcinoma

Ueda,

Dias,

Carneiro

et al. 2024

Archives of Endocrinology and Metabolism

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“…The CNN loss function is determined as in Equation (24). In CNN, the constraints (𝜃) liked to the essential n input-output association are indicated as…”

Section: Optimized Cnn Modelmentioning

confidence: 99%

“…Moreover, the objective function of adopted model is determined in Equation (25), where Loss is determined in Equation (24).…”

Section: Objective Function and Solution Encodingmentioning

confidence: 99%

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Optimization assisted convolutional neural network for detection of thyroid

Suresh¹,

Brijet²

2022

Concurrency and Computation

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This research work endeavor to suggest a new thyroid detection system that involves three main processes like segmentation, feature extraction, and detection. Initially, for the segmentation process, an improved watershed algorithm is proposed. Besides, from the segmented image, it extracted the texture features that comprises local binary patterns, modified GLCM feature, local tetra pattern features, together with the statistical features. Primarily, the extracted features are given as an input to convolutional neural network (CNN) for the final detection result. For making the detection more accurate, the training of deep CNN is performed via a new deer encircling included gray wolf optimization model for optimal weights tuning. The adopted hybrid algorithm combines gray wolf optimization and deer hunting optimization algorithm. At last, the outcomes of the adopted scheme is validated with the extant approaches under various metrics.

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“…In this line of reasoning, previous reports demonstrated that 18 F-NaF PET/CT can detect bone metastases 2,3 and, occasionally, soft tissue metastases 4,5 of MTC, in some cases better than 68 Ga-labeled somatostatin analogs 2,6 . This uptake of the 18 F-NaF in soft tissue metastases of MTC is not completely understood but could be due to the presence of calcification in amyloid deposition that frequently occurs in these tumors 7 .…”

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confidence: 94%

Re: Visualization of Tumor Heterogeneity in Advanced Medullary Thyroid Carcinoma by Dual-Tracer Molecular Imaging: Revealing the Theranostic Potential of SSTR- and PSMA-Directed Endoradiotherapy

Duarte¹

2022

Clin Nucl Med

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I have just read the article by Hasenauer et al 1 in Clinical Nuclear Medicine. The authors described a patient with advanced medullary thyroid carcinoma (MTC) treated with 177 Lu-DOTATOC that presented multiple nonavid lesions after 2 cycles of therapy depicted on 68 Ga-DOTATOC PET/CT. The patient then underwent a prostate-specific membrane antigen PET/CT that demonstrated increased expression of this radiopharmaceutical in both 68 Ga-DOTATOCavid and nonavid lesions, suggesting tumor heterogeneity. Accordingly, the authors raised the possibility to use prostate-specific membrane antigen-targeted radioligand therapy in selected MTC patients.In this line of reasoning, previous reports demonstrated that 18 F-NaF PET/CT can detect bone metastases 2,3 and, occasionally, soft tissue metastases 4,5 of MTC, in some cases better than 68 Ga-labeled somatostatin analogs. 2,6 This uptake of the

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Comparison of 18F-NaF PET/CT with Other Imaging Methods in the Detection of Bone Metastases in Patients with Medullary Thyroid Cancer: a Report of a Series of 31 Cases

Cited by 14 publications

References 31 publications

Correlation of 18F-sodium fluoride uptake and radiodensity in extraosseous metastases of medullary thyroid carcinoma

Correlation of 18F-sodium fluoride uptake and radiodensity in extraosseous metastases of medullary thyroid carcinoma

Optimization assisted convolutional neural network for detection of thyroid

Re: Visualization of Tumor Heterogeneity in Advanced Medullary Thyroid Carcinoma by Dual-Tracer Molecular Imaging: Revealing the Theranostic Potential of SSTR- and PSMA-Directed Endoradiotherapy

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