2022
DOI: 10.1097/rlu.0000000000004430
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Comparison of 18F-PSMA-1007 PET/CT With 68Ga-PSMA-11 PET/CT for Initial Staging in Intermediate- and High-Risk Prostate Cancer

Abstract: Ga-PSMA-11 PET/CT for initial staging in intermediate-and high-risk prostate cancer (PCa) patients. Methods: Forty treatment-naive, biopsy-proven, intermediate-or high-risk PCa patients were prospectively recruited. Each patient underwent PET/ CT with 68 Ga-PSMA-11 and 18 F-PSMA-1007 (within 2 weeks). Assessment of both set of images included delineating number and characteristics of lesions, measurement of tracer uptake (SUV max ), miPSMA scoring, and PET-based stage categorization. Results: Intraprostatic le… Show more

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Cited by 12 publications
(8 citation statements)
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“…In one prospective head-to-head analysis, the sensitivity of [ 18 F]PSMA-1007 vs [ 68 Ga]Ga-PSMA-11 was 100% vs 85.7%; the specificity was 90.9% vs 98.2%; the positive predictive value (PPV) was 87.5% vs 96.8%; the NPV was 100% vs 91.5%, the accuracy was 94.5% vs 93.3% [15]. In another prospective head-tohead comparison, [ 18 F]PSMA-1007 and [ 68 Ga]Ga-PSMA-11 were both able to detect the dominant lesions [16]. However, [ 18 F] PSMA-1007 was able to appreciate focal lesions better and detected three additional LN lesions [16].…”
Section: Primary Stagingmentioning
confidence: 94%
“…In one prospective head-to-head analysis, the sensitivity of [ 18 F]PSMA-1007 vs [ 68 Ga]Ga-PSMA-11 was 100% vs 85.7%; the specificity was 90.9% vs 98.2%; the positive predictive value (PPV) was 87.5% vs 96.8%; the NPV was 100% vs 91.5%, the accuracy was 94.5% vs 93.3% [15]. In another prospective head-tohead comparison, [ 18 F]PSMA-1007 and [ 68 Ga]Ga-PSMA-11 were both able to detect the dominant lesions [16]. However, [ 18 F] PSMA-1007 was able to appreciate focal lesions better and detected three additional LN lesions [16].…”
Section: Primary Stagingmentioning
confidence: 94%
“…The rationale to use 18 F instead of 68 Ga is based on the limited short halflife of 68 Ga, the cost of a 68 Ga generator, and the high positron energy that theoretically could limit the spatial resolution and therefore the diagnostic accuracy in small lesions [90][91][92]. Comparative studies of 18 F-PSMA-1007 and 68 Ga-PSMA-11 carried out in mCRPC patients demonstrated a similar potential for detecting prostatic lesions [93][94][95]. 18 F-PSMA-1007 was also evaluated in pre-clinical GBM models, as PSMA imaging has recently gained attention in this indication.…”
Section: Development Of 18 F-psma-1007 For Imagingmentioning
confidence: 99%
“…FIGURE 2. For staging, 18 F-PSMA-1007 PET/CT scan was performed [1][2][3]. Anterior (A) and lateral (B) MIP PET showed an irregular area (arrows) of heterogeneous activity in the prostate region.…”
mentioning
confidence: 99%
“…For staging, 18 F-PSMA-1007 PET/CT scan was performed. [1][2][3] Anterior (A) and lateral (B) MIP PET showed an irregular area (arrows) of heterogeneous activity in the prostate region. Transverse CT at the levels of the mid (C) and basal (D) prostate, corresponding PET (E and F) and fused (G and H) images showed heterogeneous activity (straight arrows) of the prostate and intense heterogeneous activity (curved arrow) with SUV max of 11.9 of the mass of the left seminal vesicle.…”
mentioning
confidence: 99%