Comparison of 2- and 3-category histologic grading systems for predicting the presence of metastasis at the time of initial evaluation in dogs with cutaneous mast cell tumors: 386 cases (2009–2014)

Stefanello, D.; Buracco, Paolo; Sabattini, Silvia; Finotello, Riccardo; Giudice, Chiara; Grieco, Valeria; Iussich, Selina; Tursi, Massimiliano; Scase, T.; Palma, Stefano Di; Bettini, Giuliano; Ferrari, Roberta; Martano, Marina; Gattino, Francesca; Marrington, Mary; Mazzola, M.; Vasconi, Maria Elisabetta; Annoni, Maurizio; Marconato, Laura

doi:10.2460/javma.246.7.765

Cited by 92 publications

(175 citation statements)

References 22 publications

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“…In most previous studies, LN examination for tumor staging was limited to a single LN . In our study, 46.5% of the tumors had several LNs assessed for staging.…”

Section: Discussionmentioning

confidence: 72%

Investigation of the utility of lymph node fine‐needle aspiration cytology for the staging of malignant solid tumors in dogs

Fournier

Cazzini

Bavčar

et al. 2018

Veterinary Clinical Pathol

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“…In most previous studies, LN examination for tumor staging was limited to a single LN . In our study, 46.5% of the tumors had several LNs assessed for staging.…”

Section: Discussionmentioning

confidence: 72%

Investigation of the utility of lymph node fine‐needle aspiration cytology for the staging of malignant solid tumors in dogs

Fournier

Cazzini

Bavčar

et al. 2018

Veterinary Clinical Pathol

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“…The variable “location” was categorized in 2 groups: sites historically associated with worse prognosis (head and neck, genital [including inguinal, scrotal, perivulvar and perineal] and digit) vs sites historically associated with better prognosis (lateral thorax and abdomen, and limb, excluding digits) . Longest tumour diameter was included in its original continuous measurement scale (interval of 1 cm) and also considered as categorical variable, coded as 0 if < 3 cm and 1 if >3 cm . First, univariate analysis was performed for each of the above‐mentioned variables, and then multivariate analysis was performed to evaluate the joint role of the variables.…”

Section: Methodsmentioning

confidence: 80%

“…Taking into consideration the aforementioned statement, further studies should be designed to better explain the negative prognostic correlation between Patnaik grades II and III cMCT and nodal metastasis, and the low rate of nodal metastasis for Kiupel high‐grade tumours reported in the present work. Notably, the application of both grading systems simultaneously also failed to clarify the prognostic role on non‐palpable and normal‐sized RLN metastasis detection . These results highlight the complexity of the relationship and maybe the independency between staging and grading in cMCT in dogs.…”

Section: Discussionmentioning

confidence: 99%

The impact of extirpation of non‐palpable/normal‐sized regional lymph nodes on staging of canine cutaneous mast cell tumours: A multicentric retrospective study

Ferrari

Marconato

Buracco

et al. 2018

Vet Comparative Oncology

102

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Metastasis to regional lymph nodes (RLNs) in dogs with cutaneous mast cell tumour (cMCT) has been correlated with shortened survival time and higher risk of spread to distant sites. In the present study, extirpation of non-palpable or normal-sized RLNs was included in the surgical management of cMCT in dogs. Correlations between histological nodal status (HN0-3) and tumour variables were analysed. Ninety-three dogs with single cMCT without distant metastasis that underwent wide surgical excision of the primary tumour and extirpation of non-palpable or normal-sized RLN were included. The association between HN (HN0 vs HN > 0; HN0-1 vs HN2-3) and tumour variables (site, longest diameter, ulceration, 3-tier and 2-tier histological grades) was analysed by a generalized linear model with multinomial error. Then, 33 (35.5%) RLNs were HN0, 14 (15%) were HN1, 26 (28%) were HN2 and 20 (21.5%) were HN3. The presence of positive (HN > 0) RLN was significantly associated with cMCT larger than 3 cm. No other association was statistically significant. Non-palpable/normal-sized RLN in dogs with cMCT can harbour histologically detectable metastatic disease in nearly half of the cases. Extirpation of the RLN should always perfomed to obtain a correct staging of the disease, even in the absence of clinical suspicion of metastasis. Further studies should evaluate the possible therapeutical effect of the tumour burden reduction obtained by exrtipartion of a positive RLN.

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“…Approximately, 20% of dogs with cutaneous mast cell tumours (cMCTs) have nodal metastasis (stage II) at initial diagnosis . LN metastasis has been associated with decreased survival time (ST) in several studies .…”

Section: Introductionmentioning

confidence: 99%

Therapeutic impact of regional lymphadenectomy in canine stage II cutaneous mast cell tumours

Marconato

Polton

Stefanello

et al. 2018

Vet Comparative Oncology

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111

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Lymph node (LN) metastasis in canine cutaneous mast cell tumours (cMCTs) is a well-known negative prognostic factor. The role of lymphadenectomy in the treatment of stage II disease remains controversial because of its uncertain therapeutic benefit. Aim of this retrospective study was to investigate the impact of lymphadenectomy on tumour control and survival for dogs with stage II cMCTs. Dogs with firstly occurring, histologically confirmed cMCT with LN metastasis undergoing resection of the primary tumour and medical treatment thereafter were retrospectively enrolled. Dogs were classified into two groups: LN sampling (LNS; diagnosis of metastasis obtained by cytology) and regional LN dissection (LND; diagnosis obtained by histopathology). To determine the therapeutic value of lymphadenectomy, the characteristics of recurrence (local, nodal and distant) and survival were compared between groups. Evaluated outcome variables included signalment, anatomic location, diameter, ulceration, substage, surgical margins, Patnaik grading, Kiupel grading and medical treatment. Overall, 152 dogs were included: 81 underwent LND as part of primary surgery and 71 LNS. The median follow-up time was 409 days for LND group and 620 days for LNS group. On univariable analysis, the risk of developing local, nodal or distant relapse was significantly higher in the LNS group compared with LND (P < 0.001). On multivariable analysis, the risk of tumour progression and tumour-related death were 5.47 and 3.61 times higher in the LNS group, respectively (P < 0.001). Regional lymphadenectomy may have therapeutic value and improve prognosis in dogs with stage II cMCTs undergoing surgical removal of the primary tumour and medical treatment.

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Comparison of 2- and 3-category histologic grading systems for predicting the presence of metastasis at the time of initial evaluation in dogs with cutaneous mast cell tumors: 386 cases (2009–2014)

Abstract: Findings indicated that in dogs with cutaneous MCTs, prognostication should not rely on histologic grade alone, regardless of grading system used, but should take into account results of clinical staging.

Cited by 92 publications

References 22 publications

Investigation of the utility of lymph node fine‐needle aspiration cytology for the staging of malignant solid tumors in dogs

Investigation of the utility of lymph node fine‐needle aspiration cytology for the staging of malignant solid tumors in dogs

The impact of extirpation of non‐palpable/normal‐sized regional lymph nodes on staging of canine cutaneous mast cell tumours: A multicentric retrospective study

Therapeutic impact of regional lymphadenectomy in canine stage II cutaneous mast cell tumours

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