Comparison of 2 three-day Helicobacter pylori eradication regimens with a standard one week regimen: A randomized, investigator-blind study

Grimley, C. E.; Penny, Alan F.; O’Sullivan, Maria; Shebani, M; Lismore, J R; Cross, Ray; Illing, R. C.; De, Loft; Nwokolo, CU

doi:10.1016/s0016-5085(98)80570-2

Cited by 1 publication

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“…O 40 mg/day (usually given as 20 mg b.d. ) 35 , 38 , 39 , 44 , 48 –50 , 56 , 64 , 127 , 128 , 130 –137 , 142 –147 , 149 –151 , 153 resulted in 85.0% ( n = 1469/1729) eradication compared with 78.0% ( n = 534/685) with O 20 mg/day 36 , . 125 , 129 , 131 , 132 , 138 –141 , 144 , 148 , 152…”

Section: Resultsmentioning

confidence: 98%

“…Of 46 reported studies, 35 , 36 , 38 , 39 , 44 , 48 –50 , 56 , 64 , 125 , 127 –153 ITT rates could be determined from all but eight 69 , . 78 , 154 –159 The pooled eradication rate was 83.0% ( n = 2003/2414); range 45–100% 136 , 139 from 42 treatment arms.…”

Section: Resultsmentioning

confidence: 99%

“…The dose of C most frequently used was 250 mg b.d 36 , 38 , 44 , 48 –50 , 64 , 125 , 127 –132 , 134 , 135 , 137 –140 , 143 , 144 , 146 , 148 –152 . giving an average eradication rate of 82.9% ( n = 1335/1622); range 45–97% 139 , .…”

Section: Resultsmentioning

confidence: 99%

“…M 500 mg b.d 35 , . 44 , 56 , 125 , 127 , 128 , 130 –133 , 135 , 139 , 140 , 147 , 152 , 153 and 400 mg b.d 36 , 38 , 39 , 48 –50 , 64 , 129 , 134 , 137 , 138 , 142 , 143 , 146 , 151 . have been used in about equal numbers of studies.…”

Section: Resultsmentioning

confidence: 99%

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One‐week clarithromycin triple therapy regimens for eradication of Helicobacter pylori

Pipkin

Williamson

Wood

1998

Aliment Pharmacol Ther

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Background: One‐week triple therapies have been endorsed as the treatment regimens of choice for eradication of Helicobacter pylori infection. Those that include clarithromycin appear to be the most effective. Aim: To review reports of triple therapies that include clarithromycin. Methods: Reports were identified from the literature to May 1998. The variation between study designs prevents a formal meta‐analysis. A measure of the relative efficacies of regimens has, however, been gained by comparison and by pooling of intention‐to‐treat eradication rates. Results: One hundred and ninety‐two studies were identified which included 264 treatment arms of a 1‐week triple therapy composed of clarithromycin with amoxycillin or a nitroimidazole (metronidazole or tinidazole), and either ranitidine bismuth citrate or a proton pump inhibitor (omeprazole, lansoprazole or pantoprazole). From reports of these studies, an intention‐to‐treat H. pylori eradication rate could be determined from 210 treatment arms of 151 studies. Conclusions: There is little to choose between the efficacies of 1‐week clarithromycin‐based triple therapy eradication regimens. However, those comprising clarithromycin, a nitroimidazole and either ranitidine bismuth citrate or a high dose of omeprazole are, in general, the most effective. Against antibiotic‐resistant strains of H. pylori, regimens including ranitidine bismuth citrate may be more effective than those including a proton pump inhibitor.

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