For the maxilla there are no studies, at the present time, that can be utilized to address the question of how many implants should support an overdenture. For the mandible, it cannot be concluded that bone loss, patient satisfaction, or number of complications is significantly related to the number of implants supporting the overdenture. Furthermore, splinting two implants does not seem to offer additional value. Well conducted research is needed to identify the prognostic factors for long-term success.