1999
DOI: 10.1592/phco.19.1.94.30512
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Comparison of 24‐Hour Ambulatory Blood Pressure Data in Hypertensive Patients Switched from Nifedipine‐GITS to Nifedipine‐CC

Abstract: This study suggests that patients switched from Nif-GITS to Nif-CC could experience increased blood pressure during the night or toward the end of the dosing interval. They could also experience adverse effects such as headache, edema, and dizziness, which could result in more physician visits and put patients with other disease states such as coronary heart disease at increased risk.

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Cited by 5 publications
(4 citation statements)
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“…There have been inconsistent findings when switching from one dihydropyridine CCB to another or when switching to different formulations of the same drug to lessen or resolve peripheral edema 29–31 . Edema will diminish upon conversion from a dihydropyridine CCB to a nondihydropyridine CCB such as verapamil or diltiazem.…”
Section: Treatment Of Ccb‐related Edemamentioning
confidence: 99%
“…There have been inconsistent findings when switching from one dihydropyridine CCB to another or when switching to different formulations of the same drug to lessen or resolve peripheral edema 29–31 . Edema will diminish upon conversion from a dihydropyridine CCB to a nondihydropyridine CCB such as verapamil or diltiazem.…”
Section: Treatment Of Ccb‐related Edemamentioning
confidence: 99%
“…An additional option in certain instances (where the glomerular filtration rate decrease is not excessive) is to consider CCB therapy together with an ACE inhibitor (or ARB). [160][161][162] Resolution of peripheral edema by drug switching (at least with the older CCBs) is unlikely to reflect fundamental biologic differences between drugs. 158 The chronic use of CCBs has also been shown to be a cause of bilateral symmetric false-positive captopril renography in patients with established renal artery stenosis.…”
Section: Ccb Overdosementioning
confidence: 99%
“…Among the several dihydropyridine CCBs, there have been inconsistent findings when switching from one dihydropyridine CCB to another or when converting to different formulations of the same drug to lessen or resolve the peripheral edema. [160][161][162] Resolution of peripheral edema by drug switching (at least with the older CCBs) is unlikely to reflect fundamental biologic differences between drugs. 162 If there is a relevant difference in the biology of these compounds, it would have to be ascribed to differences in vascular permeability and/or differing effects on precapillary and postcapillary vascular resistance.…”
Section: Chronopharmacologymentioning
confidence: 99%
“…In animal models, proliferation and migration of VSMC begin soon after vascular injury occurs and culminate in formation of a neointima that encroaches on the interior space of the vessel (1). Such neointima formation is seen in a substantial number of patients following balloon angioplasty and may result in a narrowing or blockage (restenosis) of the vessel that requires further intervention (2). By preventing the immediate proliferation of VSMC following vascular injury, it may be possible to avert neointima formation and restenosis.…”
Section: Although Vascular Smooth Muscle Cells (Vsmc)mentioning
confidence: 99%