Comparison of 25 and 50 microgram of misoprostol for induction of labour in nulliparous women with postdate pregnancy in Port Harcourt

Azubuike, IJ; Bassey, G; Okpani, Aou

doi:10.4103/1119-3077.151056

Cited by 12 publications

(4 citation statements)

References 21 publications

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“…There was no statistical significant difference in their incidence in both groups. Gastrointestinal side-effects were consistent with findings from other studies, and were significantly increased with high dose group as 17,20 compared to low dose group. This finding may represent the wide range of response to misoprostol 9 in different women.…”

Section: Discussionsupporting

confidence: 90%

“…Thus, multiple dosing at four hourly intervals with high dose 50µg of Misoprostol may have a synergic effect with resultant serious complications. The dosing intervals and the preformed 25µg tablets used in this study, may have accounted for why there was no incidence of ruptured uterus, despite other studies linking misoprostol use to the high incidence of 20,24,25 uterine rupture. Oxytocin need as well as women who delivered after 24 hours, were significantly higher among the low dose group, as compared to those in the high dose group in this study.…”

Section: Discussionmentioning

confidence: 79%

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comparison of two dosing regimens of vaginally administered misoprostol for cervical ripening and induction of labour at term: A randomized controlled trial

Muhammad YE,

Abdullahi HM,

Digol IG

et al. 2020

Ibom Med J

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Background: The use of misoprostol in induction of labour has become established, but there exist wide variations in the dosing regimen.Objective: The aim of this study was to compare the efficacy and safety of two regimens of intravaginal misoprostol for cervical ripening and labour induction at term.Method: This prospective randomized clinical trial was conducted on 130 pregnant women at term in Aminu Kano Teaching Hospital, Kano, Nigeria. Those who fulfilled the criteria were randomized into 2 groups to receive intravaginal misoprostol tablets for 24 hours. Study group (A) received 4 hourly 25 µg misoprostol and Control group (B) 6 hourly 50 µg of misoprostol. Student t test, chi-square and Fisher Exact test were used to compare variables. P< 0.05 was considered statistically significant.Results: Both regimens were effective in cervical ripening and induction of labour with 93.8% and 98.5% achieving vaginal deliveries for 25 µg and 50 µg groups respectively. Oxytocin need was significantly higher (p<0.001) in group A (76.9%) compared to group B (23.1%). The Mean induction- delivery interval in hours was significantly shorter (p< 0.001) in group B (19.31±6.91) compared to group A (25.57±7.25). The percentage of women who delivered within 24 hours of commencement of induction was significantly higher (p= 0.002) in group B. There was no difference in the modes of deliveries in both groups (p =0.074). Tachysystole developed in two and three women in group A and B respectively. There were no significant differences between the two groups in neonates with Apgar score < 7 at 1 minute, Apgar score < 7 at 5 minutes, nor the proportion admitted to NICU. There was no difference in the incidence of adverse maternal effects in each group with p- values > 0.05.Conclusion: The mean induction-vaginal delivery interval and the number of women who delivered within 24 hours were better in 50µg group than 25µg group with no statistical significant difference in mode of deliveries, maternal and neonatal outcomes.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 79%

comparison of two dosing regimens of vaginally administered misoprostol for cervical ripening and induction of labour at term: A randomized controlled trial

Muhammad YE,

Abdullahi HM,

Digol IG

et al. 2020

Ibom Med J

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“…The need to augment labour with oxytocin infusion occurred in 22.41% of subjects. This rate was lower than those found in the Cochrane review (39.07%), as well as in a study in Nigeria (41.86%) 16,17 . However, this result was higher than those reported in Pakistan and in another region in Nigeria, 12% and 16.4% respectively 18,19 .…”

Section: Discussioncontrasting

confidence: 74%

“…Oxytocin was required for augmentation in 22.41%. This result was lower than what was recorded in Port Harcourt, Nigeria (41.9%) but higher than those recorded in Pakistan (12%) and in Ibadan, Nigeria (15.9%) , 17,18,19 . This difference might be explained by the variation in protocols.…”

Section: Discussioncontrasting

confidence: 67%

Outcomes In Elective Induction Of Labour With μg Intravaginal Misoprostol In Postdate Singleton Live Pregnancy At Korle-Bu Teaching Hospital

Kaboré,

Nuamah,

Koranteng

et al. 2022

gcps

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Background: Induction of labour is indicated when the risk associated with expectant management of labour is higher. The most common indication for labour induction is postdate pregnancy and induction for this indication has been shown to reduce perinatal death. Misoprostol is the most commonly used drug for labour induction at the Korle-Bu Teaching, the leading national referral centre in Ghana. Method: To assess the outcomes in Elective Induction of Labour using 50 μg of intravaginal misoprostol in postdate singleton live pregnancies at Korle-Bu Teaching Hospital. This was a prospective cohort study carried out to measure the rates of vaginal deliveries and factors affecting vaginal deliveries during labour induction. One hundred and sixteen pregnant women of at least 41 weeks gestation. Women were included and followed up from the first insertion of misoprostol to delivery.Results: Eighty-six patients (74.1%) had vaginal delivery and 30 (25.9%) were delivered by caesarean section. Among those who delivered vaginally, 77 (89.5%) delivered within 24 hours. There was a significant association between mode of delivery and Bishop Score (P=0.002). The highest Apgar score at the first minute was 7 in 55 babies (47.4%) and the lowest was 3 in 2 babies (1.7%).Conclusions: The high rate of vaginal delivery and absence of induction related perinatal mortality confirmed the effectiveness and safety of misoprostol in postdate singleton live pregnancy at Korle-Bu Teaching Hospital.

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Vitamin D deficiency in pregnant women and newborns in Lagos, Nigeria

Owie

Afolabi

2018

Journal of Obstetrics and Gynaecology

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We aimed to determine the prevalence of Vitamin D deficiency among pregnant women and their newborns in order to make recommendations for Vitamin D supplementation, if necessary. It was a cross-sectional study carried out over a period of 12 months. Information such as use of Vitamin D supplements, number of daytime hours spent outdoors and dressing style was obtained from 166 pregnant women in Lagos, Nigeria; maternal and cord blood 25(OH)D concentration was determined using ELISA. The prevalence of Vitamin D deficiency (<20 ng/mL) in the mothers and newborns was 4.8% and 29.5%, respectively, while insufficiency (21-29 ng/mL) was 28.3% and 46.1%, respectively. Vitamin D supplement use during pregnancy, daytime outdoor exposure and mothers' dressing style were significantly associated with maternal serum 25(OH)D concentration (p < .05). Our study showed that despite a sunny environment like ours, inadequate serum 25(OH)D concentration is still considerable among pregnant women and their newborns and suggests a need for Vitamin D supplementation in pregnant women. Impact Statement What is already known on this subject? Vitamin D is an essential vitamin that plays a major role in maintaining pregnancy and ensuring adequate skeletal formation in the foetus. Studies have shown that there is high Vitamin D deficiency in pregnant women in the temperate regions of the world and thus Vitamin D supplements are being offered to these pregnant women. Studies have also shown that the foetal/neonatal serum Vitamin D level is a reflection of the maternal level. What the results of this study add? The results of this study adds that there may be some factors preventing adequate delivery of Vitamin D from the maternal circulation to the foetal circulation, because despite a low prevalence of Vitamin D deficiency in the mothers, their neonates had a high deficiency rate. What the implications are of these findings for clinical practice and/or further research? The implications of these findings are; further research is warranted in order to find what could be causing a reduced delivery of Vitamin D from the mothers to their foetuses, so as to prevent it if possible. Second, these findings suggest that our pregnant women should still receive a form of Vitamin D supplements, so as to raise their serum Vitamin D to a level which would guarantee optimal foetal concentration.

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Comparison of 25 and 50 microgram of misoprostol for induction of labour in nulliparous women with postdate pregnancy in Port Harcourt

Abstract: Intravaginal administration of 25 μg of misoprostol appears to be as effective, but safer than 50 μg for induction of labor in nulliparous women with postdate pregnancy.

Cited by 12 publications

References 21 publications

comparison of two dosing regimens of vaginally administered misoprostol for cervical ripening and induction of labour at term: A randomized controlled trial

comparison of two dosing regimens of vaginally administered misoprostol for cervical ripening and induction of labour at term: A randomized controlled trial

Outcomes In Elective Induction Of Labour With μg Intravaginal Misoprostol In Postdate Singleton Live Pregnancy At Korle-Bu Teaching Hospital

Vitamin D deficiency in pregnant women and newborns in Lagos, Nigeria

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