Comparison of 4-Class and Continuous Fat/Water Methods for Whole-Body, MR-Based PET Attenuation Correction

Wollenweber, Scott D.; Ambwani, Sonal; Lonn, A. H. R.; Shanbhag, Dattesh; Thiruvenkadam, Sheshadri; Kaushik, Sandeep; Mullick, Rakesh; Wiesinger, Florian; Qian, Hua; Delso, Gaspar

doi:10.1109/tns.2013.2278759

Cited by 79 publications

(48 citation statements)

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“…The last nine time points from 5 minutes to 30 minutes on the postinjection images were used to determine the slope by means of linear regression in the Patlak graphical analysis (23). As representative kinetic parameters reflecting FCH influx, the average and maximum K1 in the one-tissue compartment model and the K i (net influx fat and water method was used (20). PET images were then reconstructed into dynamic multiframes (6 3 10 sec, 8 3 30 sec, 5 3 1 min, and 4 3 5 min) with a matrix size of 128 3 128 (voxel size, 2.34 3 2.34 3 2.78 mm; transaxial field of view, 30 cm).…”

Section: Resultsmentioning

confidence: 99%

¹⁸F Fluorocholine Dynamic Time-of-Flight PET/MR Imaging in Patients with Newly Diagnosed Intermediate- to High-Risk Prostate Cancer: Initial Clinical-Pathologic Comparisons

Choi¹,

Yang²,

Noworolski³

et al. 2017

Radiology

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Purpose:To investigate the initial clinical value of fluorine 18 ( 18 F) fluorocholine (FCH) dynamic positron emission tomography (PET)/ magnetic resonance (MR) imaging by comparing its parameters with clinical-pathologic findings in patients with newly diagnosed intermediate-to high-risk prostate cancer (PCa) who plan to undergo radical prostatectomy. Materials andMethods:The institutional review board approved the study protocol, and informed written consent was obtained from all subjects for this HIPAA-compliant study. Results:Of the PET parameters, maximum SUV of primary tumors showed significant correlations with several clinical-pathologic parameters including serum prostate-specific antigen level (r = 0.71, P = .01), pathologic stage (r = 0.59, P = .043), and postsurgical CAPRA score (r = 0.72, P = .008). The overall PI-RADS score showed significant correlations with pathologic tumor volume (r = 0.81, P , .001), percentage of tumor cells with Gleason scores greater than 3 (r = 0.59, P = .02), and postsurgical CAPRA score (r = 0.58, P = .046). The high-risk postsurgical CAPRA score patient group had a significantly higher maximum SUV than did the intermediate-risk group. Combined PET and MR imaging showed improved sensitivity (88%) for prediction of pathologic extraprostatic extension compared with that with MR imaging (50%) and PET (75%) performed separately. Conclusion:Maximum SUVs and PI-RADS scores from FCH PET/MR imaging show good correlation with clinical-pathologic characteristics, such as postsurgical CAPRA score, which are related to prognosis in patients with newly diagnosed intermediate-to high-risk PCa.q RSNA, 2016

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Section: Resultsmentioning

confidence: 99%

¹⁸F Fluorocholine Dynamic Time-of-Flight PET/MR Imaging in Patients with Newly Diagnosed Intermediate- to High-Risk Prostate Cancer: Initial Clinical-Pathologic Comparisons

Choi¹,

Yang²,

Noworolski³

et al. 2017

Radiology

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“…Axial slices were reconstructed at a 2.78-mm thickness. Attenuation was corrected using a 2-echo Dixon fat-water separation algorithm for the body, whereas the lung was segmented using a region-growing algorithm provided with the scanner (16).…”

Section: Human Experimentsmentioning

confidence: 99%

⁶⁸Ga-PSMA-11 PET Imaging of Response to Androgen Receptor Inhibition: First Human Experience

et al. 2016

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The purpose of this work was to evaluate the effect of androgen receptor (AR) inhibition on prostate-specific membrane antigen (PSMA) uptake imaged using 68 Ga-PSMA-11 PET in a mouse xenograft model and in a patient with castration-sensitive prostate cancer. Methods: We imaged 3 groups of 4 mice bearing LNCaP-AR xenografts before and 7 d after treatment with ARN-509, orchiectomy, or control vehicle. Additionally, we imaged one patient with castration-sensitive prostate cancer before and 4 wk after treatment with androgen deprivation therapy (ADT). Uptake on pre-and posttreatment imaging was measured and compared. Results: PSMA uptake increased 1.5-to 2.0-fold in the xenograft mouse model after treatment with both orchiectomy and ARN-509 but not with vehicle. Patient imaging demonstrated a 7-fold increase in PSMA uptake after the initiation of ADT. Thirteen of 22 lesions in the imaged patient were visualized on PSMA PET only after treatment with ADT. Conclusion: Inhibition of the AR can increase PSMA expression in prostate cancer metastases and increase the number of lesions visualized using PSMA PET. The effect seen in cell and animal models can be recapitulated in humans. A better understanding of the temporal changes in PSMA expression is needed to leverage this effect for both improved diagnosis and improved therapy.

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“…Quantitative corrections applied during image reconstruction included normalization, dead time, point-spread function, randoms, scatter, decay, and attenuation. The latter was based on a four-tissue-class (air, lung, fat, and soft tissue) segmented attenuation map, automatically generated from the results of the MR-based attenuation correction acquisition (Lava Flex; GE Healthcare) (13). The attenuation coefficients for air (0 cm…”

Section: Data Processingmentioning

confidence: 99%

Effect of Time-of-Flight Information on PET/MR Reconstruction Artifacts: Comparison of Free-breathing versus Breath-hold MR-based Attenuation Correction

Delso¹,

Khalighi²,

E³

et al. 2017

Radiology

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Purpose To evaluate the magnitude and anatomic extent of the artifacts introduced on positron emission tomographic (PET)/magnetic resonance (MR) images by respiratory state mismatch in the attenuation map. Materials and Methods The method was tested on 14 patients referred for an oncologic examination who underwent PET/MR imaging. The acquisition included standard PET and MR series for each patient, and an additional attenuation correction series was acquired by using breath hold. PET data were reconstructed with and without time-of-flight (TOF) information, first by using the standard free-breathing attenuation map and then again by using the additional breath-hold map. Two-tailed paired t testing and linear regression with 0 intercept was performed on TOF versus non-TOF and freebreathing versus breath-hold data for all detected lesions. Results Fluorodeoxyglucose-avid lesions were found in eight of the 14 patients included in the study. The uptake differences (maximum standardized uptake values) between PET reconstructions with free-breathing versus breath-hold attenuation ranged, for non-TOF reconstructions, from -18% to 26%. The corresponding TOF reconstructions yielded differences from -15% to 18%. Conclusion TOF information was shown to reduce the artifacts caused at PET/MR by respiratory mismatch between emission and attenuation data. (©) RSNA, 2016 Online supplemental material is available for this article. DOI: https://doi.org/10. 1148/radiol.2016152509 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-125777 Published Version Originally published at: Delso, Gaspar; Khalighi, Mohammed; Ter Voert, Edwin E G W; Barbosa, Felipe; Sekine, Tetsuro; Hüllner, Martin; Veit-Haibach, Patrick (2016 Purpose:To evaluate the magnitude and anatomic extent of the artifacts introduced on positron emission tomographic (PET)/ magnetic resonance (MR) images by respiratory state mismatch in the attenuation map. Materials and Methods:The method was tested on 14 patients referred for an oncologic examination who underwent PET/MR imaging. The acquisition included standard PET and MR series for each patient, and an additional attenuation correction series was acquired by using breath hold. PET data were reconstructed with and without time-of-flight (TOF) information, first by using the standard free-breathing attenuation map and then again by using the additional breath-hold map. Two-tailed paired t testing and linear regression with 0 intercept was performed on TOF versus non-TOF and free-breathing versus breath-hold data for all detected lesions. Results:Fluorodeoxyglucose-avid lesions were found in eight of the 14 patients included in the study. The uptake differences (maximum standardized uptake values) between PET reconstructions with free-breathing versus breath-hold attenuation ranged, for non-TOF reconstructions, from 218% to 26%. The corresponding TOF reconstructions yielded differences from 215% to 18%. Conclusion:TOF information was shown to red...

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Comparison of 4-Class and Continuous Fat/Water Methods for Whole-Body, MR-Based PET Attenuation Correction

Cited by 79 publications

References 10 publications

¹⁸F Fluorocholine Dynamic Time-of-Flight PET/MR Imaging in Patients with Newly Diagnosed Intermediate- to High-Risk Prostate Cancer: Initial Clinical-Pathologic Comparisons

¹⁸F Fluorocholine Dynamic Time-of-Flight PET/MR Imaging in Patients with Newly Diagnosed Intermediate- to High-Risk Prostate Cancer: Initial Clinical-Pathologic Comparisons

⁶⁸Ga-PSMA-11 PET Imaging of Response to Androgen Receptor Inhibition: First Human Experience

Effect of Time-of-Flight Information on PET/MR Reconstruction Artifacts: Comparison of Free-breathing versus Breath-hold MR-based Attenuation Correction

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Comparison of 4-Class and Continuous Fat/Water Methods for Whole-Body, MR-Based PET Attenuation Correction

Cited by 79 publications

References 10 publications

18F Fluorocholine Dynamic Time-of-Flight PET/MR Imaging in Patients with Newly Diagnosed Intermediate- to High-Risk Prostate Cancer: Initial Clinical-Pathologic Comparisons

18F Fluorocholine Dynamic Time-of-Flight PET/MR Imaging in Patients with Newly Diagnosed Intermediate- to High-Risk Prostate Cancer: Initial Clinical-Pathologic Comparisons

68Ga-PSMA-11 PET Imaging of Response to Androgen Receptor Inhibition: First Human Experience

Effect of Time-of-Flight Information on PET/MR Reconstruction Artifacts: Comparison of Free-breathing versus Breath-hold MR-based Attenuation Correction

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¹⁸F Fluorocholine Dynamic Time-of-Flight PET/MR Imaging in Patients with Newly Diagnosed Intermediate- to High-Risk Prostate Cancer: Initial Clinical-Pathologic Comparisons

¹⁸F Fluorocholine Dynamic Time-of-Flight PET/MR Imaging in Patients with Newly Diagnosed Intermediate- to High-Risk Prostate Cancer: Initial Clinical-Pathologic Comparisons

⁶⁸Ga-PSMA-11 PET Imaging of Response to Androgen Receptor Inhibition: First Human Experience