Comparison of 6-Month Outcomes of Survivors of COVID-19 versus Non–COVID-19 Critical Illness

Hodgson, Carol; Higgins, Alisa; Bailey, Michael; Mather, Anne M.; Beach, Lisa; Bellomo, Rinaldo; Bissett, Bernie; Boden, Ianthe; Bradley, Scott J.; Burrell, Aidan; Cooper, David J.; Fulcher, Bentley J; Haines, Kimberley; Hodgson, Isabelle T.; Hopkins, Jack; Jones, Alice; Lane, Stuart; Lawrence, Drew; Lee, Lisa van der; Liacos, Jennifer; Linke, Natalie; Gomes, Lonni Marques; Nickels, Marc; Ntoumenopoulos, George; Myles, Paul S.; Patman, Shane; Paton, Michelle; Pound, Gemma; Rai, Sumeet; Rix, Alana; Rollinson, Thomas C; Tipping, Claire J; Thomas, Peter J.; Trapani, Tony; Udy, Andrew; Whitehead, Christina; Anderson, Shannah; Neto, Ary Serpa

doi:10.1164/rccm.202110-2335oc

Cited by 64 publications

(60 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This result suggests that COVID-19 initiates a greater acute burden of care than other illnesses with a similar level of initial respiratory compromise. This is perhaps in contrast to Hodgson's finding of comparable rates of new disability in both COVID+ and COVID− at 6 months post mechanical ventilation for acute respiratory failure [26].…”

Section: Discussioncontrasting

confidence: 96%

“…Specifically, those presenting to an ED with SpO 2 < 90% on RA, requiring oxygen > 3 L/min to stabilise, were more likely to need mechanical ventilation and/or inpatient rehabilitation, whereas factors of age, comorbidity or BMI had less impact on care trajectory. The duration of mechanical ventilation correlated with a need for inpatient rehabilitation, in keeping with the known impact of ICU-AW, irrespective of the effects of COVID-19 [14,26]. This association complements the impact of mechanical ventilation duration on muscle weakness, the rate of mobility progression and new disabilities in COVID-19 reported elsewhere [25,35,36].…”

Section: Discussionsupporting

confidence: 75%

“…Importantly, people hospitalised with COVID-19 have demonstrated persistant functional impairment requiring inpatient and/or outpatient rehabilitation [23][24][25]. A recently published study demonstrated that new disability attributed to COVID-19 in mechanically ventilated patients with respiratory failure occurs at the same rate as those ventilated for other causes of respiratory failure [26]. However, the burden of COVID-19 during emergency department presentation and hospital admission, when compared to the burden of other illnesses that lead to respiratory symptoms, is yet to be investigated.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Greater In-Hospital Care and Early Rehabilitation Needs in People with COVID-19 Compared with Those without COVID-19

Grove

Edgar

Chih

et al. 2022

JCM

View full text Add to dashboard Cite

This study aims to compare the characteristics, in-hospital data and rehabilitation needs between those who tested positive versus negative for COVID-19 during hospitalisation with suspected COVID-19. In this cross-sectional study, a convenience sample of adults admitted to Western Australian tertiary hospitals with suspected COVID-19 was recruited. Participants were grouped according to their polymerase chain reaction (PCR) test result into COVID-19 positive (COVID+) and COVID-19 negative (COVID−) groups. Between-group comparisons of characteristics of the participants and hospital admission data were performed. Sixty-five participants were included (38 COVID+ and 27 COVID−; 36 females [55%]). Participants in the COVID+ group had greater acute hospital length of stay (LOS) (median [25–75th percentile] 10 [5–21] vs. 3 [2–5] days; p < 0.05] and only those with COVID+ required mechanical ventilation (8 [21%] participants). Twenty-one percent of the COVID+ participants were discharged to inpatient rehabilitation (7% of the COVID− participants). Of note, pre-existing pulmonary disease was more prevalent in the COVID− group (59% vs. 13%; p < 0.05). Within the COVID+ group, when compared to participants discharged home, those who required inpatient rehabilitation had worse peripheral oxygen saturation (SpO2) on admission (86 ± 5.7% vs. 93 ± 3.8%; p < 0.05) and longer median LOS (30 [23–37] vs. 7 [4–13] days; p < 0.05). Despite having less people with pre-existing pulmonary disease, the COVID+ group required more care and rehabilitation than the COVID− group. In the COVID+ group, SpO2 on hospital presentation was associated with LOS, critical care needs, mechanical ventilation duration and the need for inpatient rehabilitation.

show abstract

Section: Discussioncontrasting

confidence: 96%

Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Greater In-Hospital Care and Early Rehabilitation Needs in People with COVID-19 Compared with Those without COVID-19

Grove

Edgar

Chih

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…This result should be interpreted with caution because it could be explained by the overlap of ARDS sequelae ( 25 , 26 ), the so-called postintensive care syndrome (PICS) ( 27 ) and the post-COVID syndrome ( 28 ). Interestingly, a study performed by Hodgson and colleagues ( 29 , 30 ) showed that COVID-19 and non-COVID-19 PICS at 6 months after ICU admission are at least phenotypically similar, with similar post-ICU care. Be that as it may and consequently, these critical survivors have a high consumption rate of health resources ( 31 ) that must be managed in an adequate post-COVID care unit.…”

Section: Discussionmentioning

confidence: 99%

One Year Overview and Follow-Up in a Post-COVID Consultation of Critically Ill Patients

et al. 2022

View full text Add to dashboard Cite

The long-term clinical management and evolution of a cohort of critical COVID-19 survivors have not been described in detail. We report a prospective observational study of COVID-19 patients admitted to the ICU between March and August 2020. The follow-up in a post-COVID consultation comprised symptoms, pulmonary function tests, the 6-minute walking test (6MWT), and chest computed tomography (CT). Additionally, questionnaires to evaluate the prevalence of post-COVID-19 syndrome were administered at 1 year. A total of 181 patients were admitted to the ICU during the study period. They were middle-aged (median [IQR] of 61 [52;67]) and male (66.9%), with a median ICU stay of 9 (5–24.2) days. 20% died in the hospital, and 39 were not able to be included. A cohort of 105 patients initiated the follow-up. At 1 year, 32.2% persisted with respiratory alterations and needed to continue the follow-up. Ten percent still had moderate/severe lung diffusion (DLCO) involvement (<60%), and 53.7% had a fibrotic pattern on CT. Moreover, patients had a mean (SD) number of symptoms of 5.7 ± 4.6, and 61.3% met the criteria for post-COVID syndrome at 1 year. During the follow-up, 46 patients were discharged, and 16 were transferred to other consultations. Other conditions, such as emphysema (21.6%), COPD (8.2%), severe neurocognitive disorders (4.1%), and lung cancer (1%) were identified. A high use of health care resources is observed in the first year. In conclusion, one-third of critically ill COVID-19 patients need to continue follow-up beyond 1 year, due to abnormalities on DLCO, chest CT, or persistent symptoms.

show abstract

“…144 Reports of longer-term outcomes of survivors of ARDS with COVID-19 are emerging and provide evidence of persistent physical, mental, and cognitive deficits. 15,16,[145][146][147][148] Evidence of persistent interstitial lung disease in patients with ARDS related to COVID-19 who were mechanically ventilated has been reported, but there remains uncertainty as to how relevant this evidence is to a population of patients with non-COVID-19 ARDS. 10,149,150 Of note, some studies have shown better health-related quality of life, 16 and higher return to work rates in patients with COVID-19 ARDS compared with a non-COVID-19 ARDS population.…”

Section: Sequelae Of Ardsmentioning

confidence: 99%

Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management

Gorman¹,

O’Kane²,

McAuley³

2022

The Lancet

153

View full text Add to dashboard Cite

Comparison of 6-Month Outcomes of Survivors of COVID-19 versus Non–COVID-19 Critical Illness

Abstract: Author Contributions: Drs Serpa Neto and Hodgson had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Cited by 64 publications

References 33 publications

Greater In-Hospital Care and Early Rehabilitation Needs in People with COVID-19 Compared with Those without COVID-19

Greater In-Hospital Care and Early Rehabilitation Needs in People with COVID-19 Compared with Those without COVID-19

One Year Overview and Follow-Up in a Post-COVID Consultation of Critically Ill Patients

Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management

Contact Info

Product

Resources

About