2019
DOI: 10.1371/journal.pone.0226339
|View full text |Cite
|
Sign up to set email alerts
|

Comparison of 6-week PMTCT outcomes for HIV-exposed and HIV-unexposed infants in the era of lifelong ART: Results from an observational prospective cohort study

Abstract: BackgroundLifelong antiretroviral therapy (ART) reduces mother-to-child HIV transmission (MTCT) and improves maternal health. Data on the outcomes of HIV-exposed infants (HEI) compared to their unexposed counterparts in the era of universal ART is limited. We compared birth and 6-week outcomes among infants born to HIV-positive and HIV-negative women in Lesotho. Methods 941HIV-negative and 653 HIV-positive pregnant women were enrolled in an observational cohort to evaluate the effectiveness of prevention of mo… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
3
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 6 publications
(3 citation statements)
references
References 22 publications
0
3
0
Order By: Relevance
“…31,33,38,39 The assessment of gestational age was specified in only nine of the 27 studies. 24,34,36,[39][40][41][42][43][44] In eight studies it was based on the last menstrual period and corrected if needed by the first trimester ultrasound scan and in one study it was based on the ultrasound measurement obtained between 10 and 13+6 weeks. 39…”
Section: Outcome Definitionsmentioning
confidence: 99%
“…31,33,38,39 The assessment of gestational age was specified in only nine of the 27 studies. 24,34,36,[39][40][41][42][43][44] In eight studies it was based on the last menstrual period and corrected if needed by the first trimester ultrasound scan and in one study it was based on the ultrasound measurement obtained between 10 and 13+6 weeks. 39…”
Section: Outcome Definitionsmentioning
confidence: 99%
“…In our study, lack of, or unknown receipt of maternal ART, which also served as infant MTCT prophylaxis, was associated with HIV-positive final outcome status among HEI. This is a well-documented phenomenon among both final outcome [ 19 , 22 ] and early MTCT studies [ 21 , 30 ]. Prior studies have established that lack of; or inadequate HIV treatment or prophylaxis results in a higher maternal viral load during pregnancy, delivery or breastfeeding [ 31 – 33 ].…”
Section: Discussionmentioning
confidence: 95%
“…Characteristics of included studies are summarised in Table 1[13,18,19,26–82]. Twenty-six (43%) prospective and 35 (57%) retrospective cohort studies analysed data from 409 781 women in 27 countries (Table 1).…”
Section: Resultsmentioning
confidence: 99%