Comparison of [68 Ga]Ga-DOTA-FAPI-04 PET/CT and [18F]FDG PET/CT in colorectal cancer

Kömek, Halil; Can, Canan; Kaplan, İhsan; Gündoğan, Cihan; Kepenek, Ferat; Karaoğlan, Hüseyin; Demirkıran, Aykut; Ebinç, Senar; Güzel, Yunus; Gündeş, Ebubekir

doi:10.1007/s00259-022-05839-0

Cited by 52 publications

(43 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result was consistent with the recently study reported by Halil et al. ( 21 ). Thus, [ 68 Ga]Ga-FAPI-04 PET/CT might be more advantageous than [ 18 F]F-FDG PET/CT to improve detecting efficiency in T stage.…”

Section: Discussionsupporting

confidence: 94%

“…[ 68 Ga]Ga-FAPI-04 is an active fibroblast-targeted imaging agent, and the development of peritoneal metastases is primarily because of active fibroblasts ( 28 ), which is supported by the significantly higher [ 68 Ga]Ga-FAPI-04 uptake in peritoneal metastatic lesions compared with [ 18 F]F-FDG uptake observed in this study. This result was also consistent with the previous studies ( 13 , 21 ).…”

Section: Discussionsupporting

confidence: 94%

“…However, the average TBR of treatment-naïve lesions was significantly higher on [ 68 Ga]Ga-FAPI-04 PET/CT than on [ 18 F] F-FDG PET/CT. This result was consistent with the recently study reported by Halil et al (21). Thus, [ 68 Ga]Ga-FAPI-04 PET/CT might be more advantageous than [ 18 F]F-FDG PET/CT to improve detecting efficiency in T stage.…”

Section: Discussionsupporting

confidence: 93%

“…Owing to moderate FDG uptake in the liver, [ 18 F]F-FDG PET/CT was not the first choice for identifying liver metastasis. Our data revealed that the hepatic background intensity was significantly lower in [ 68 Ga]Ga-FAPI-04 PET/CT than that in [ 18 F]F-FDG PET/CT, corroborating the findings of previous studies ( 9 , 11 , 21 ). The TBR values of liver metastases were higher in [ 68 Ga]Ga-FAPI-04 than those in [ 18 F]F-FDG PET/CT in this study.…”

Section: Discussionsupporting

confidence: 92%

“…In this study, the smallest lesion detected had a diameter of approximately 0.7 cm. However, Halil et al (21) found that both the SUV max and TBR values of liver metastases were signifcantly higher in [ 18 F]F-FDG than those in [ 68 Ga]Ga-FAPI-04 PET/CT. We believe that this issue can be clarified with future studies involving larger and homogeneous cohorts.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Diagnostic value of [68Ga]Ga-FAPI-04 in patients with colorectal cancer in comparison with [18F]F-FDG PET/CT

Lin

Wang

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

PurposeThis study aimed to compare the diagnostic performance of [68Ga]Ga-FAPI-04 PET/CT and [18F]F-FDG PET/CT in primary and metastatic colorectal cancer (CRC) lesions.MethodsThis single-center preliminary clinical study (NCT04750772) was conducted at the Peking University Cancer Hospital & Institute and included 61 participants with CRC who underwent sequential evaluation through PET/CT with [18F]F-FDG and [68Ga]Ga-FAPI-04. Their PET/CT images were analysed to quantify the uptake of the two tracers in the form of maximum standardised uptake (SUVmax) values and target-to-background ratio (TBR), which were then compared using Wilcoxon’s signed-rank test. The final changes in the tumour–node–metastasis (TNM) stage of all participants were recorded.ResultsOf all the participants, 21 were treatment naïve and 40 had been previously treated. In primary CRC lesions, the average TBRs of [68Ga]Ga-FAPI-04 and [18F]F-FDG were 13.3 ± 8.9 and 8.2 ± 6.5, respectively. The SUVmax of [68Ga]Ga-FAPI-04 in signet-ring/mucinous carcinomas (11.4 ± 4.9) was higher than that of [18F]F-FDG (7.9 ± 3.6) (P = 0.03). Both median SUVmax in peritoneal metastases and TBR in liver metastases of [68Ga]Ga-FAPI-04 were higher than those of [18F]F-FDG (5.2 vs. 3.8, P < 0.001; 3.7 vs. 1.9, P < 0.001, respectively). Compared with [18F]F-FDG PET/CT, clinical TNM staging based on [68Ga]Ga-FAPI-04 PET/CT led to upstaging and downstaging in 10 (16.4%) and 5 participants (8.2%), respectively. Therefore, the treatment options were changed in 13 participants (21.3%), including 9 with additional chemo/radiotherapy and/or surgery and others with avoidance or narrowed scope of surgery.Conclusion[68Ga]Ga-FAPI-04 showed potential as a novel PET/CT tracer to detect lymph nodes and distant metastases, which improved CRC staging, thus prompting the optimisation or adjustment of treatment decisions.

show abstract

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Diagnostic value of [68Ga]Ga-FAPI-04 in patients with colorectal cancer in comparison with [18F]F-FDG PET/CT

Lin

Wang

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

show abstract

Clinical applications of fibroblast activation protein‐targeted theranostics in oncologic and nononcologic disease: Current status and future directions

Fu,

Guo,

Huang

et al. 2023

iRADIOLOGY

View full text Add to dashboard Cite

Quinoline‐based fibroblast activation protein (FAP) inhibitor (FAPI)‐based positron emission tomography (PET) imaging and radioligand therapy (RLT) are being investigated for use in a wide variety of diseases, and recent results have been promising. This review summarizes the current status of FAPI radiopharmaceuticals in PET imaging of malignant tumors and benign conditions and compares their diagnostic efficacy with 18F‐fluorodeoxyglucose. In addition, we summarize the previously published FAP‐targeted RLT data and discuss its current clinical use and future potential. Our qualitative summary can inform future research directions, medical guidelines, and optimal clinical decision‐making.

show abstract

Early detection of radiation-induced myocardial damage by [18F]AlF-NOTA-FAPI-04 PET/CT imaging

Sun

Liu

et al. 2022

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

Comparison of [68 Ga]Ga-DOTA-FAPI-04 PET/CT and [18F]FDG PET/CT in colorectal cancer

Cited by 52 publications

References 42 publications

Diagnostic value of [68Ga]Ga-FAPI-04 in patients with colorectal cancer in comparison with [18F]F-FDG PET/CT

Diagnostic value of [68Ga]Ga-FAPI-04 in patients with colorectal cancer in comparison with [18F]F-FDG PET/CT

Clinical applications of fibroblast activation protein‐targeted theranostics in oncologic and nononcologic disease: Current status and future directions

Early detection of radiation-induced myocardial damage by [18F]AlF-NOTA-FAPI-04 PET/CT imaging

Contact Info

Product

Resources

About