Comparison of 68Ga-FAPI-04 and fluorine-18-fluorodeoxyglucose PET/computed tomography in the detection of ovarian malignancies

Zheng, Wenlu; Liu, Lin; Feng, Yue; Wang, Li; Chen, Yue

doi:10.1097/mnm.0000000000001653

Cited by 21 publications

(12 citation statements)

References 32 publications

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“…In addition, a retrospective study by Zheng et al. ( 57 ) in 27 patients with pathologically confirmed ovarian cancer showed that compared with 18 F-FDG, 68 Ga-FAPI PET/CT could more accurately differentiate between the different types of malignant ovarian tumors, including high-grade serous carcinomas (HGSC), low-grade serous carcinomas (LGSC), and ovarian mucinous carcinoma. Moreover, Zheng et al.…”

Section: Ovarian Cancermentioning

confidence: 99%

“…Moreover, Zheng et al. ( 57 ) found that 68 Ga-FAPI PET/CT was more sensitive than 18 F-FDG PET/CT in the detection of primary ovarian tumors (14/14 (100%) versus 11/14 (78%)), lymph node metastasis (75/75 (100%) versus 60/75 (80%)), and peritoneal and pleural metastasis (9/9 (100%) versus 5/9 (56%). These findings suggest that 68 Ga-FAPI PET/CT could supplement the diagnostic information provided by 18 F-FDG PET/CT.…”

Section: Ovarian Cancermentioning

confidence: 99%

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Applications of FAPI PET/CT in the diagnosis and treatment of breast and the most common gynecologic malignancies: a literature review

Li,

Zhang,

Yan

et al. 2024

Front. Oncol.

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The fibroblast activating protein (FAP) is expressed by some fibroblasts found in healthy tissues. However, FAP is overexpressed in more than 90% of epithelial tumors, including breast and gynecological tumors. As a result, the FAP ligand could be used as a target for diagnosis and treatment purposes. Positron emission tomography/computed tomography (PET/CT) is a hybrid imaging technique commonly used to locate and assess the tumor’s molecular and metabolic functions. PET imaging involves the injection of a radiotracer that tends to accumulate more in metabolically active lesions such as cancer. Several radiotracers have been developed to target FAP in PET/CT imaging, such as the fibroblast-activation protein inhibitor (FAPI). These tracers bind to FAP with high specificity and affinity, allowing for the non-invasive detection and quantification of FAP expression in tumors. In this review, we discussed the applications of FAPI PET/CT in the diagnosis and treatment of breast and the most common gynecologic malignancies. Radiolabeled FAPI can improve the detection, staging, and assessment of treatment response in breast and the most common gynecologic malignancies, but the problem with normal hormone-responsive organs remains insurmountable. Compared to the diagnostic applications of FAPI, further research is needed for future therapeutic applications.

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Section: Ovarian Cancermentioning

confidence: 99%

Section: Ovarian Cancermentioning

confidence: 99%

Applications of FAPI PET/CT in the diagnosis and treatment of breast and the most common gynecologic malignancies: a literature review

Li,

Zhang,

Yan

et al. 2024

Front. Oncol.

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“…Zheng et al retrospectively compared [ 68 Ga]Ga-FAPI-04 and FDG PET/CT in 21 patients with suspected (n = 11) or already diagnosed (n = 10) primary ovarian malignancy. FAPI was more sensitive than FDG PET/CT for the detection of primary tumors (100% vs. 78%), nodal metastases (100% vs. 80%), and peritoneal/pleural involvement (100% vs. 56%), leading to upstaging of disease in 19% (4/21) of the patients [118]. Figure 8 shows an example of FAPI PET/CT in a patient with ovarian malignancy.…”

Section: Breast Cancer and Other Gynecological Malignanciesmentioning

confidence: 99%

FAPI PET/CT Imaging—An Updated Review

et al. 2023

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Despite revolutionizing the field of oncological imaging, Positron Emission Tomography (PET) with [18F]Fluorodeoxyglucose (FDG) as its workhorse is limited by a lack of specificity and low sensitivity in certain tumor subtypes. Fibroblast activation protein (FAP), a type II transmembrane glycoprotein, is expressed by cancer-associated fibroblasts (CAFs) that form a major component of the tumor stroma. FAP holds the promise to be a pan-cancer target, owing to its selective over-expression in a vast majority of neoplasms, particularly epithelial cancers. Several radiolabeled FAP inhibitors (FAPI) have been developed for molecular imaging and potential theranostic applications. Preliminary data on FAPI PET/CT remains encouraging, with extensive multi-disciplinary clinical research currently underway. This review summarizes the existing literature on FAPI PET/CT imaging with an emphasis on diagnostic applications, comparison with FDG, pitfalls, and future directions.

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“…The role of [ 68 Ga]Ga-FAPI is still being explored as scores of papers are being published demonstrating the use of this tracer in various oncologic and non-oncologic applications [16]. It was found to have comparable performance to [ 18 F]F-FDG PET in patients with head and neck carcinoma and soft tissue sarcomas [17,18], while it outperformed [ 18 F]F-FDG PET in abdominal and pelvic malignancies (gastric, ovarian, hepatocellular, and bladder) [19][20][21][22][23]. It also fared well in IGG4 related diseases [24].…”

Section: Introductionmentioning

confidence: 99%

“…It also fared well in IGG4 related diseases [24]. In gynecological malignancies, [ 68 Ga]Ga-FAPI, displayed higher accuracy for detecting malignant lesions as is seen in ovarian cancer with carcinomatosis [19]. In a study that evaluated the use of [ 68 Ga]Ga-FAPI in cervical cancer, the authors correlated their imaging findings with histopathological results from surgical specimen [25].…”

Section: Introductionmentioning

confidence: 99%

Correlation between [68Ga]Ga-FAPI-46 PET Imaging and HIF-1α Immunohistochemical Analysis in Cervical Cancer: Proof-of-Concept

Mokoala,

Lawal,

Maserumule

et al. 2023

Cancers

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Hypoxia leads to changes in tumor microenvironment (upregulated CAFs) with resultant aggressiveness. A key factor in the physiological response to hypoxia is hypoxia-inducible factor-1alpha (HIF-1α). [68Ga]Ga-FAPI PET imaging has been demonstrated in various cancer types. We hypothesized that [68Ga]Ga-FAPI PET may be used as an indirect tracer for mapping hypoxia by correlating the image findings to pathological analysis of HIF-1α expression. The [68Ga]Ga-FAPI PET/CT scans of women with cancer of the cervix were reviewed and the maximum and mean standardized uptake value (SUVmax and SUVmean) and FAPI tumor volume (FAPI-TV) were documented. Correlation analysis was performed between PET-derived parameters and immunohistochemical staining as well as between PET-derived parameters and the presence of metastasis. Ten women were included. All patients demonstrated tracer uptake in the primary site or region of the primary. All patients had lymph node metastases while only six patients had distant visceral or skeletal metastases. The mean SUVmax, SUVmean, and FAPI-TV was 18.89, 6.88, and 195.66 cm3, respectively. The average FAPI-TV for patients with additional sites of metastases was higher than those without. Immunohistochemistry revealed varying intensities of HIF-1α expression in all tested samples. There was a positive correlation between the presence of skeletal metastases and staining for HIF-1α (r=0.80;p=0.017). The presence of skeletal metastasis was correlated to the HIF-1⍺ staining (percentage distribution). Furthermore, the FAPI-TV was a better predictor of metastatic disease than the SUVmax.

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Comparison of 68Ga-FAPI-04 and fluorine-18-fluorodeoxyglucose PET/computed tomography in the detection of ovarian malignancies

Cited by 21 publications

References 32 publications

Applications of FAPI PET/CT in the diagnosis and treatment of breast and the most common gynecologic malignancies: a literature review

Applications of FAPI PET/CT in the diagnosis and treatment of breast and the most common gynecologic malignancies: a literature review

FAPI PET/CT Imaging—An Updated Review

Correlation between [68Ga]Ga-FAPI-46 PET Imaging and HIF-1α Immunohistochemical Analysis in Cervical Cancer: Proof-of-Concept

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