Comparison of 68Ga-FAPI and 18F-FDG PET/CT in the Imaging of Pancreatic Cancer With Liver Metastases

Abstract

A 65-year-old man with suspected pancreatic cancer underwent 18F-FDG PET/CT for initial staging. Mild FDG uptake was observed in the pancreatic mass and bone destruction in the 10th rib on the right. No significant FDG uptake was seen with the multiple hypodense or isodense nodules in the liver. However, 68Ga-FAPI PET/CT revealed intense FAPI uptake in the pancreas and the 10th rib and multiple lesions in the liver. Finally, a biopsy confirmed carcinoma in the head of the pancreas with liver metastasis. This case highlighted that 68Ga-FAPI may outperform 18F-FDG PET/CT in identifying micrometastases of bones and hidden liver metastases.

Bone Marrow Metastases From Gastric Adenocarcinoma on 68Ga-FAPI-04 PET/CT

“…Unfortunately, the patient died 18 days later.68 Ga-FAPI-04 is a radiotracer derived from quinoline-based FAPIs, and it has been shown to be a valuable tool for detecting primary and metastatic lesions associated with a range of solid tumors [1][2][3][4][5]. Gastric lesions were more obvious on 68 Ga-FAPI-04 PET/CT than on 18 F-FDG PET/CT,[4][5][6][7][8] as our case shows. In addition, this case highlights that when the 68 Ga-FAPI-04 PET/CT shows widespread FAPI uptake in bone marrow, metastases should be considered in the differential diagnosis.…”

The Application of [68Ga]‐Labeled FAPI‐04 PET/CT for Targeting and Early Detection of Pancreatic Carcinoma in Patient‐Derived Orthotopic Xenograft Models

“…It still needed more exploration of initial ere are already some studies in humans with the same objective presented. For example, both Kaghazchi [42] and Deng et al [33] reported one patient with advanced pancreatic adenocarcinoma, imaged with [ 18 F]FDG and [ 68 Ga] FAPI PET/CT scans, respectively. ey found the intensity and SUVs of the lesions were higher in [ 68 Ga]FAPI scan compared with [ 18 F]FDG.…”

FAPI PET/CT in the Diagnosis of Abdominal and Pelvic Tumors

“…Studies were also performed on a 65-year-old male patient with suspected pancreatic cancer using 18 F-FDG and 68 Ga-FAPI PET/CT. The uptake intensity of 68 Ga-FAPI PET/CT was higher than that of 18 F-FDG in the head of the pancreas and the 10th rib on the right side, and the patient was eventually diagnosed with pancreatic cancer (106). These studies showed that 68 Ga-FAPI PET/CT was better than 18 F-FDG PET/ CT for diagnosing pancreatic cancer (107).…”