Comparison of 99Mo Metabolism in Young Cattle and Swine

Jk, Miller; Br, Moss; Mc, Bell; Nn, Sneed

doi:10.2527/jas1972.345846x

Cited by 24 publications

(9 citation statements)

References 8 publications

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“…1978) may alter the perspective. In one experiment with calves it was found that the absorbability of Mo was reduced during its passage through the rumen and that the primary site of absorption was the small intestine (Miller et al 1972). Mo metabolism in sheep can, however, be markedly affected by changes in dietary composition (Bell 1966), notably in the S constituent (Dick, 1956).…”

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confidence: 99%

Some effects of sulphur intake on molybdenum metabolism in sheep

Grace

Suttle

1979

Br J Nutr

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I .To investigate the effects of sulphur intake on molybdenum metabolism in sheep, ewes were given intakes of 0.3 or 3 3 mg Mo and G98, 1.33, 1.73 or 3.23 g S/d in a 2 x 4 factorial experiment with two replicates lasting 35 d. ggMo with 0.1 mg carrier M o was infused intravenously for the last 14 d and, when 8 g M~ concentrations in urine and faeces had attained plateaux (days I 1-14), stable Mo and 8oMo balance trials were conducted; samples of blood and rumen contents were taken principally for studies of Mo distribution.2. Increases in S intake caused the following changes in Mo metabolism; absorption decreased, urinary and faecal endogenous excretion decreased and retention increased; Mo concentrations in rumen contents decreased but the predominant association with the solid phase was unaffected; Mo concentrations in plasma decreased, but a higher proportion was associated with the protein fraction; Mo in protein-free plasma became apparently less ultrafiltrable at the glomerulus. 3.The pattern of response to S for each factor was generally curvilinear, the first increment in S intake having by far the greatest effect. The effect of S was generally greatest at the higher Mo intake.4. It is suggested that the manifold effects of S on M o metabolism are related to a common interaction in the rumen leading to the formation of Mo-complexes, possibly thiomolybdates, which are poorly absorbed but even more poorly excreted.Interest in the molybdenum metabolism of ruminants has centred on its role in interrelationships with copper and sulphur (Underwood, 1971) [. 1978) may alter the perspective. In one experiment with calves it was found that the absorbability of Mo was reduced during its passage through the rumen and that the primary site of absorption was the small intestine (Miller et al. 1972). Mo metabolism in sheep can, however, be markedly affected by changes in dietary composition (Bell 1966), notably in the S constituent (Dick, 1956). Dick (1956) concluded from a series of experiments that an increase in sulphate intake invariably reduced the retention of Mo but the specific contributions of changes in absorption and excretion to the interaction were not distinguished. The object of this paper is, therefore, to report the changes in Mo metabolism which occur when S intake is varied for sheep at the relatively low Mo intakes commonly encountered under grazing conditions (cf. Whitehead, 1966;Miltimore & Mason, 1971): a preliminary report of this work has been published elsewhere . M A T E R I A L S A N D M E T H O D SExperimental design. Sixteen Scottish Blackface ewes, weighing 45-55 kg and equipped with rumen fistulas, were allocated at random in block design to a 2 x 4 factorial experiment with two replicates. Two intakes of Mo (0.3 and 3.5 mg/d) and four intakes of S (0.98, Balance technique, Steps were taken to ensure that conditions in the rumen and in the whole animal were close to a state of equilibrium. The daily allowance of semi-purified diet (750 g dry matter (DM); Suttle & Field, 1968) was di...

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confidence: 99%

Some effects of sulphur intake on molybdenum metabolism in sheep

Grace

Suttle

1979

Br J Nutr

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“…A higher absorption capacity of hexavalent molybdenum (Mo 6+ ), which is readily absorbed following oral administration, can be seen in nonruminant animals compared to ruminant animals. In contrast, tetravalent molybdenum (Mo 4+ ) has been found to not be readily absorbed [34]. Within the human gastrointestinal tract, the absorption of dietary molybdenum is estimated to be between 30% and 70% [35].…”

Section: Molybdenum Entry Routes In Animalsmentioning

confidence: 99%

Microbiological Reduction of Molybdenum to Molybdenum Blue as a Sustainable Remediation Tool for Molybdenum: A Comprehensive Review

Yakasai

Rahman

Manogaran

et al. 2021

IJERPH

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Molybdenum (Mo) microbial bioreduction is a phenomenon that is beginning to be recognized globally as a tool for the remediation of molybdenum toxicity. Molybdenum toxicity continues to be demonstrated in many animal models of spermatogenesis and oogenesis, particularly those of ruminants. The phenomenon has been reported for more than 100 years without a clear understanding of the reduction mechanism, indicating a clear gap in the scientific knowledge. This knowledge is not just fundamentally important—it is specifically important in applications for bioremediation measures and the sustainable recovery of metal from industrial or mine effluent. To date, about 52 molybdenum-reducing bacteria have been isolated globally. An increasing number of reports have also been published regarding the assimilation of other xenobiotics. This phenomenon is likely to be observed in current and future events in which the remediation of xenobiotics requires microorganisms capable of degrading or transforming multi-xenobiotics. This review aimed to comprehensively catalogue all of the characterizations of molybdenum-reducing microorganisms to date and identify future opportunities and improvements.

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“…In monogastrics, Mo absorption occurs from the stomach throughout the intestinal tract (Bell et al, 1964;Miller et al, 1972;Nielsen, 1996). In monogastrics, Mo absorption occurs from the stomach throughout the intestinal tract (Bell et al, 1964;Miller et al, 1972;Nielsen, 1996).…”

Section: Pharmacokinetics/ Toxicokinetics Absorptionmentioning

confidence: 99%

“…In contrast, ruminant absorption occurs in the intestinal tract, as an extensive delay in peak blood concentration would indicate that rumen absorption does not occur. But, Mo absorption does not appear to be regulated at the point of mucosal absorption, as increasing Mo concentrations presented to the mucosa result in concomitant increased absorption (Miller et al, 1972;Turnlund et al, 1995). Absorption is quite efficient, being from 40 to 90% (Friberg and Lener, 1986;Turnlund et al, 1995).…”

Section: Pharmacokinetics/ Toxicokinetics Absorptionmentioning

confidence: 99%

Molybdenum

Hall¹

2012

Veterinary Toxicology

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Comparison of 99Mo Metabolism in Young Cattle and Swine

Cited by 24 publications

References 8 publications

Some effects of sulphur intake on molybdenum metabolism in sheep

Some effects of sulphur intake on molybdenum metabolism in sheep

Microbiological Reduction of Molybdenum to Molybdenum Blue as a Sustainable Remediation Tool for Molybdenum: A Comprehensive Review

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