Comparison of a 'Freeze-All' Strategy Versus a 'Fresh Transfer' Strategy Among Poor Responders in Assisted Reproductive Technology (Art)

Abstract

Background: The standard procedure in ART is the use of fresh embryo transfer (FET) which has stood the test of time. But in recent years, frozen embryo transfer has also been used by many quite successfully and it may be a viable alternative to FET. Aim and Objective: The main aim of the study is to nd out if the clinical pregnancy rate per randomized patient after the rst good quality blastocyst transfer is superior in a freeze-all as compared with same cycle transfer strategy in poor responders. The main objective of present study is to compare the 'freeze-all' strategy with same cycle transfer strategy among poor responders in articial conception technology. Methods: An observational, prospective, cohort study was conducted between August 2018 and January 2019. In total, 102 poor responder patients (as per Poseidon criteria) were taken for COS with GnRH antagonist stimulation protocol and blastocyst stage embryo transfer was performed. Clinical pregnancy rate and ongoing pregnancy rate were signicantly higher in frozen em Results: bryo transfer group than fresh embryo transfer group. Conclusion: In poor responder group of patients, IVF outcomes can be improved by implementing freeze all policy. Major concern in poor responder patients is reduced oocyte competence due to availability of lesser oocyte. Therefore, better outcomes could be achieved with the help of Pre implantation genetic screening synchronized with latest endometrium receptivity markers which is only possible with freeze all policy.