In this chapter, the motivation for this book is given. The analysis process of socio-technical systems based on data and models is examined from the perspective of uncertainty. The synthesis process of systems based on models and/or intuition leads to the important concepts of function and quality as well as data, model, and structural uncertainty. This forms both the foundation and the introduction to the following chapters. It is shown that the mastering of uncertainty is the key to Sustainable Systems Design. Thus, the societal need for safety and sustainability is met.