Comparison of a novel predictor of venous thromboembolic complications in inflammatory bowel disease with current predictors

Ohta, Yuki; Arai, Makoto; Nakagawa, Tomoo; Akizue, Naoki; Ishikawa, Kentaro; Hamanaka, Shinsaku; Koseki, Hirotaka; Taida, Takashi; Okimoto, Kenichiro; Saito, Keiko; Yoshihama, Sayuri; Maruoka, Daisuke; Matsumura, Tomoaki; Katsuno, Tatsuro; Kato, Naoya

doi:10.1111/jgh.14472

Cited by 13 publications

(11 citation statements)

References 29 publications

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“…To date, several retrospective cohort studies ( 24 – 29 ) have attempted to evaluate the effect of acquired risk factors on the incidence of venous thromboembolic events in inflammatory bowel disease patients with controversial results. For instance, while some studies had reported a significantly increased risk in aging inflammatory bowel disease patients ( 24 , 27 , 30 ), other studies did not report this outcome ( 28 , 31 , 32 ). Similarly, there is still a lack of consensus regarding the risks of venous thromboembolism associated with steroid therapy, surgery, obesity in patients with inflammatory bowel disease ( 24 , 28 , 29 , 33 – 35 ).…”

Section: Introductionmentioning

confidence: 99%

“…For instance, while some studies had reported a significantly increased risk in aging inflammatory bowel disease patients ( 24 , 27 , 30 ), other studies did not report this outcome ( 28 , 31 , 32 ). Similarly, there is still a lack of consensus regarding the risks of venous thromboembolism associated with steroid therapy, surgery, obesity in patients with inflammatory bowel disease ( 24 , 28 , 29 , 33 – 35 ). To the best of our knowledge, there are no systematic reviews or meta-analyses that summarized the existing data, evaluating risk factors that can influence the incidence of venous thromboembolism in patients with inflammatory bowel disease.…”

Section: Introductionmentioning

confidence: 99%

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Risk Factors of Venous Thromboembolism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Zhang

Wang

2021

Front. Med.

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Background: Patients suffering from chronic inflammatory disorders, such as inflammatory bowel disorder, are at higher risk of developing thromboembolism. The chronic inflammatory nature of inflammatory bowel disease has been identified as a predominant reason for a state of Virchow's triad (i.e., endothelial dysfunction, stasis, and general hypercoagulability), eventually leading to the onset of venous thromboembolism. Recent studies show that certain factors, such as demographics, medication history, and history of surgical intervention may increase thromboembolism risk in patients with inflammatory bowel disease. However, to date, no study has attempted to evaluate the effect of different risk factors associated with the development of venous thromboembolism in inflammatory bowel disease patients.Objective: To evaluate the risk factors that can influence the incidence of venous thromboembolism in patients with inflammatory bowel disease.Methods: Academic literature was systematically searched based on the PRISMA guidelines across five databases: Web of Science, EMBASE, CENTRAL, Scopus, and MEDLINE. A random-effect meta-analysis was conducted to evaluate the hazard ratio for the risk factors (i.e., aging, gender, steroid therapy, surgery, and ulcerative colitis) that can influence the incidence of venous thromboembolism in patients with inflammatory bowel disease.Results: From a total of 963 studies, 18 eligible studies with 1,062,985 (44.59 ± 10.18 years) patients suffering from inflammatory bowel disease were included in the review. A meta-analysis revealed a higher risk of aging (Hazard's ratio: 2.19), steroids (1.87), surgery (1.48), and ulcerative colitis (2.06) on venous thromboembolism in patients with inflammatory bowel disease. We also found that the female gender (0.92) did not increase the incidence of venous thromboembolism in inflammatory bowel disease patients.Conclusion: The study provides preliminary evidence regarding high risks associated with ulcerative colitis, steroid consumption, and aging for the development of venous thromboembolism in patients with inflammatory bowel disease. The findings from this study may contribute to developing awareness among clinicians, better risk stratification and prevention of venous thromboembolic complications in patients with inflammatory bowel disease.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk Factors of Venous Thromboembolism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Zhang

Wang

2021

Front. Med.

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“…Elevated D-dimer values was an independent risk factor for thromboembolism in IBD. Case report also showed predictive value of D-dimer in CVST [10,11] . Role of medical treatment for IBD was in controversial.…”

Section: Discussionmentioning

confidence: 64%

Cerebral Venous Sinus Thrombosis in Patients With Inflammatory Bowel Disease: A Retrospective Study

Wang

Zhang

Bai

et al. 2021

Preprint

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BACKGROUND: Cerebral venous sinus thrombosis (CVST) is a rare and devastating complication of inflammatory bowel disease (IBD). Early diagnose and prompt treatment could improve prognosis.AIM: The aim of our study was to investigate the clinical data and risk factors of inflammatory bowel disease with diagnosis of CVST. METHODS: All data of IBD patients were collected from July 2013 and September 2020. Clinical data, risk factors and prognosis were compared between CVST in IBD patients and IBD control group. RESULTS: The incidence of CVST in our study was 0.48%. The mean age of IBD patients with CVST was 34.9 years. Average disease duration of IBD was 4 years when cerebrovascular events occur. Clinical presentation of CVST included headache (73.1%), vomiting (30.8%), limb dysmetria (26.9%), speech impairment (11.5%), blurred vision (7.7%), Epileptic seizures (7.7%) and drowsiness (3.8%). The most common location for CVST was transverse sinus (61.5%), followed by superior sagittal sinus (30.8%). Anemia, low albumin and elevated D-dimer were independent predictors of CVST in IBD patients. Anticoagulation therapy was effective. Prognosis of IBD patients with CVST was worse than those without CVST.CONCLUSION: Early identification the risk of and clinical features of CVST in IBD patients is important. Prompt antithrombotic therapy is safe and effective treatment.

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“…A recent study showed elevated D-dimer at admission was highly predictive for venous thrombosis and therefore D-dimer test might be a useful screening tool. 24 However, another study suggested that the utility of D-dimer tests as screening methods could be limited, since elevated D-dimer is common in inflammatory diseases. Therefore, though D-dimer test is economical for initial screening, direct imaging study might be more appropriate for patients with high risks.…”

Section: Discussionmentioning

confidence: 99%

“…In the current study, the modality of screening was mainly D-dimer tests, with less than 3% of patients receiving ultrasound screening or computed tomography scans. A recent study showed elevated D-dimer at admission was highly predictive for venous thrombosis and therefore D-dimer test might be a useful screening tool [ 24 ]. However, another study suggested that the utility of D-dimer tests as screening methods could be limited, since elevated D-dimer is common in inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

Incidence and risk factors for venous thrombosis among patients with inflammatory bowel disease in China: a multicenter retrospective study

et al. 2021

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of other veins such as intra-abdominal venous thrombosis. Patients with IBD, including Crohn' s disease (CD) and ulcerative colitis (UC), have an average of 2-to 4-fold risk for venous thrombosis compared to the healthy population. 1-4 Venous thrombosis results in an increased mortality rate, especially in patients who developed PE. 5,6 The development of venous thrombosis among IBD patients is a multifactorial process that follow the triad of Virchow. 7 Active inflammation further increased such risk, and therefore thromboprophylaxis has been recommended for IBD patients with high risk, in

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Comparison of a novel predictor of venous thromboembolic complications in inflammatory bowel disease with current predictors

Abstract: In hospitalized patients with IBD, D-dimer values were highly associated with VTE onset. Therefore, measurement of D-dimer values on admission is critical for the management of thromboembolic complications in patients with IBD.

Cited by 13 publications

References 29 publications

Risk Factors of Venous Thromboembolism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Risk Factors of Venous Thromboembolism in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Cerebral Venous Sinus Thrombosis in Patients With Inflammatory Bowel Disease: A Retrospective Study

Incidence and risk factors for venous thrombosis among patients with inflammatory bowel disease in China: a multicenter retrospective study

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