Comparison of a theoretical impedance model with experimental measurements of pulsatile blood flow

Gaw, Richelle L.; Cornish, Bruce; Thomas, Brian

doi:10.1007/978-3-540-73841-1_11

Cited by 5 publications

(6 citation statements)

References 17 publications

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“…Further ICG improvement might be achieved by fixing the orientation of RBCs through the cardiac cycle, reducing the influence of pulsatile flow on impedance measurement. 32 Electrophysiological techniques that examine endogenously generated signals would also benefit greatly from controlled, noninvasive modulation of tissue conductivity. ECG researchers continue to grapple with the inverse problem as they work to generate personalized cardiac electrophysiology models from surface potentials.…”

Section: Discussionmentioning

confidence: 99%

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Magnetic Manipulation of Blood Conductivity with Superparamagnetic Iron Oxide-Loaded Erythrocytes

Philips

Gleich

Paredes-Juarez

et al. 2019

ACS Appl. Mater. Interfaces

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The active and passive electrophysiological properties of blood and tissue have been utilized in a vast array of clinical techniques to noninvasively characterize anatomy and physiology and to diagnose a wide variety of pathologies. However, the accuracy and spatial resolution of such techniques are limited by several factors, including an ill-posed inverse problem, which determines biological parameters and signal sources from surface potentials. Here, we propose a method to noninvasively modulate tissue conductivity by aligning superparamagnetic iron oxide-loaded erythrocytes with an oscillating magnetic field. A prototype device is presented, which incorporates a three-dimensional set of Helmholtz coil pairs and fluid-channel-embedded electrode arrays. Alignment of loaded cells (~11 mM iron) within a field of 12 mT is demonstrated, and this directed reorientation is shown to alter the conductivity of blood by ~5 and ~0.5% for stationary and flowing blood, respectively, within fields as weak as 6-12 mT. Focal

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Section: Discussionmentioning

confidence: 99%

“…[29][30][31] In fact, this orientation-induced impedance change comprises a significant portion of the signal measured by ICG. 11,32,33 It follows that the impedance of blood, and thus tissue, could be modulated by aligning RBCs alternately with and against the flow of electrical current.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Manipulation of Blood Conductivity with Superparamagnetic Iron Oxide-Loaded Erythrocytes

Philips

Gleich

Paredes-Juarez

et al. 2019

ACS Appl. Mater. Interfaces

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“…Bioimpedance measurements have long been used for the monitoring of biological and physiological parameters [6][7][8]. In the field of heart failure, electrical impedance has also Sensors 2024, 24, 3637 2 of 8 been used to monitor body volume [3,4], hemodynamics [9], or the prediction of clinical risks [10]. There are some clinical devices currently used for the monitorization of electrical impedance in patients, such as Impedimed ® (Carlsbad, CA, USA) [9].…”

Section: Introductionmentioning

confidence: 99%

“…In the field of heart failure, electrical impedance has also Sensors 2024, 24, 3637 2 of 8 been used to monitor body volume [3,4], hemodynamics [9], or the prediction of clinical risks [10]. There are some clinical devices currently used for the monitorization of electrical impedance in patients, such as Impedimed ® (Carlsbad, CA, USA) [9]. However, one of the most important problems faced is that current existing procedures only measure electrical impedance in the patient during the hospitalization of the patient or during visits to the hospital, and continuous remote monitoring of the patient at home is not possible.…”

Section: Introductionmentioning

confidence: 99%

“…However, one of the most important problems faced is that current existing procedures only measure electrical impedance in the patient during the hospitalization of the patient or during visits to the hospital, and continuous remote monitoring of the patient at home is not possible. Certified clinical equipment for impedance spectroscopy is, in all cases, large and not portable [9]. Some wearable devices have recently been proposed to monitor impedance spectroscopy and estimate volume overload in patients with heart failure [2].…”

Section: Introductionmentioning

confidence: 99%

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Design of Wearable Textile Electrodes for the Monitorization of Patients with Heart Failure

Sánchez,

Scagliusi,

Giménez-Miranda

et al. 2024

Sensors

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Heart failure is a severe medical condition with an important worldwide incidence that occurs when the heart is unable to efficiently pump the patient’s blood throughout the body. The monitoring of edema in the lower limbs is one of the most efficient ways to control the evolution of the condition. Impedance spectroscopy has been proposed as an efficient technique to monitor body volume in patients with heart failure. It is necessary to research new wearable devices for remote patient monitoring, which can be easily worn by patients in a continuous way. In this work, we design and implement new wearable textile electrodes for the monitoring of edema evolution in patients with heart failure. Impedance spectroscopy measurements were carried out in 5 healthy controls and 2 patients with heart failure using our wearable electrodes for 3 days. The results show the appropriateness of impedance spectroscopy and our wearable electrodes to monitor body volume evolution. Impedance spectroscopy is shown to be an efficient marker of the presence of edema in heart failure patients. Initial patient positive feedback was obtained for the use of the wearable device.

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Time frequency analysis of the experimental electrical impedance of pulsatile blood flowing through rigid tubes

2009

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Comparison of a theoretical impedance model with experimental measurements of pulsatile blood flow

Cited by 5 publications

References 17 publications

Magnetic Manipulation of Blood Conductivity with Superparamagnetic Iron Oxide-Loaded Erythrocytes

Magnetic Manipulation of Blood Conductivity with Superparamagnetic Iron Oxide-Loaded Erythrocytes

Design of Wearable Textile Electrodes for the Monitorization of Patients with Heart Failure

Time frequency analysis of the experimental electrical impedance of pulsatile blood flowing through rigid tubes

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