Comparison of absolute and relative handgrip strength to predict cancer prognosis: A prospective multicenter cohort study

Xie, Hailun; Ruan, Guo‐Tian; Deng, Li; Zhang, Heyang; Ge, Yi‐Zhong; Zhang, Qi; Lin, Shiqi; Song, Mengmeng; Zhang, Xi; Liu, Xiaoyue; Li, Xiangrui; Zhang, Kangping; Yang, Ming; Tang, Meng; Hu, Wen; Wang, Min; Shi, Hanping

doi:10.1016/j.clnu.2022.06.011

Cited by 13 publications

(4 citation statements)

References 25 publications

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“…27,28 However, it is interesting to find that overweight patients with CRC diagnosed with malnutrition according to the HGS-GLIM criteria had significantly lower OS and DFS rates than the respective control cohorts, whereas those diagnosed using the GLIM criteria alone did not. Recent studies have demonstrated the predictive value of HGS for a range of clinical outcomes, including mortality, postoperative complications, and long-term survival, 15,29,30 further supporting the utility of HGS measurements in clinical practice. In addition, the HGS-GLIM criteria were shown to be an independent risk factor for total complications, OS, and DFS.…”

Section: Discussionmentioning

confidence: 86%

Predictive value of Global Leadership Initiative on Malnutrition criteria combined with handgrip strength for postoperative outcomes in overweight colorectal cancer patients

Chen,

Yu,

Ren

et al. 2024

J of Gastro and Hepatol

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Background and AimThe Global Leadership Initiative on Malnutrition (GLIM) criteria are increasingly used to assess the nutritional status of hospitalized patients and predict the prognosis of patients with malignant tumors; however, malnutrition is often overlooked in overweight individuals, such as colorectal cancer patients. This study aimed to investigate the predictive value of the GLIM criteria combined with handgrip strength (HGS) in overweight colorectal cancer patients.MethodsThis retrospective study enrolled overweight patients who underwent radical resection for colorectal cancer at two centers between 2015 and 2021. Malnutrition was diagnosed based on the GLIM criteria. Skeletal muscle mass was assessed using the skeletal muscle index, and skeletal muscle function was assessed using the HGS test. The risk factors for complications and survival were also evaluated.ResultsA total of 850 patients were enrolled in the study. The incidence of malnutrition in the GLIM and HGS‐GLIM groups was 12.4% and 6.4%, respectively. The incidence of total complications in both the malnutrition groups was significantly higher than that in the control group. Patients in the HGS‐GLIM‐malnutrition group had worse overall survival and disease‐free survival. HGS‐GLIM was independently associated with postoperative complications (P = 0.046), overall survival (P = 0.037), and disease‐free survival (P = 0.047).ConclusionThe GLIM criteria combined with the HGS test is an effective tool for diagnosing malnutrition. Particularly, these modalities are applicable in overweight colorectal cancer patients. Compared with the standard GLIM criteria, this tool has a better predictive value for postoperative complications and long‐term survival.

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Section: Discussionmentioning

confidence: 86%

Predictive value of Global Leadership Initiative on Malnutrition criteria combined with handgrip strength for postoperative outcomes in overweight colorectal cancer patients

Chen,

Yu,

Ren

et al. 2024

J of Gastro and Hepatol

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“…Previous research has suggested that relative grip strength (rGS), defined as grip strength divided by body mass index, is more strongly associated with cardiometabolic disease biomarkers than absolute grip strength [ 15 ]. However, for predicting cancer outcomes, absolute grip strength has been found to be more effective than rGS [ 16 ]. Therefore, both rGS and absolute grip strength were used to assess samples’ muscle strength in this study.…”

Section: Methodsmentioning

confidence: 99%

Association between grip strength and stress urinary incontinence of NHANES 2011–2014

Zhang,

Mao,

Sun

et al. 2023

BMC Women's Health

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Objectives To investigate the association between grip strength (GS) and relative grip strength (rGS) with the prevalence and severity risk of SUI. Methods Female patients were retrieved from the NHANES 2011–2014. GS was measured using a digital hand dynamometer, rGS was defined as grip strength divided by BMI. Samples were classified into four groups based on quartiles of GS and rGS distribution (Q1-Q4)。Logistic regression models were established to detect the relationship between GS or rGS and SUI. The potential bias of baseline variables between SUI and non-SUI groups was controlled by performing the propensity score matching (PSM). Results A total of 4263 samples were included, with 3085 (85%) people in non-SUI group and 1178 (27.6%) people in SUI group. GS and rGS levels of people without SUI were higher than that of SUI patients. Monthly SUI patients’ GS and rGS levels were higher than weekly SUI patients’ level. Logistic regression analysis showed that risks of prevalence and severity of SUI decreased with increasing levels of GS and rGS. rGS was found to have a stronger association with SUI than GS [prevalence: GS: Q4 vs. Q1: aOR = 0.633, 95%CI = 0.508–0.789, p < 0.001; rGS: Q4 vs. Q1: aOR = 0.365, 95%CI = 0.290–0.459, p < 0.001; severity: GS: Q4 vs. Q1: aOR = 0.727, 95%CI = 0.600–0.881, p = 0.001; rGS: Q4 vs. Q1: aOR = 0.371, 95%CI = 0.282–0.488, p < 0.001]. The results of PSM confirmed that GS and rGS were correlated with SUI. Conclusions Lower levels of GS and rGS are associated with an increased prevalence and severity risk of SUI.

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“…On the other hand, dynamometry is a widely used method to assess muscle strength and functional capacity in patients with cancer [ 29 ]. The measurement of muscle strength using dynamometry has been proposed as a potential marker of malnutrition in these patients [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Phase Angle, Handgrip Strength, and Other Indicators of Nutritional Status in Cancer Patients Undergoing Different Nutritional Strategies: A Systematic Review and Meta-Analysis

et al. 2023

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Malnutrition in cancer patients is one of the most influential factors in the evolution and mortality of such patients. To reduce the incidence of malnutrition, it is necessary to establish a correct nutritional intervention. For this purpose, precise tools and indicators must be developed to determine the patient’s condition. The main objective of this systematic review and meta-analysis was to analyze the relationship between different nutritional strategies, phase angle (PA), and handgrip strength in patients with cancer, with the secondary objectives being the modification of other indicators of nutritional status, such as weight and body mass index (BMI). A systematic review of randomized clinical trials was carried out in March 2023 in the databases PubMed, Web of Science, Cochrane, and Scopus. As a risk-of-bias tool, RoB 2.0 was utilized. A total of 8 studies with a total of 606 participants were included in the analysis. A significant increase in PA was observed after the different nutritional strategies (SMD: 0.43; 95% CI: 0.10 to 0.77; p = 0.01; I2 = 65.63%), also detecting a significant increase in handgrip strength (SMD: 0.27, 95% CI: 0.08 to 0.47; p = 0.01; I2 = 30.70%). A significant increase in PA and handgrip were observed in cancer patients subjected to different nutritional strategies. These results suggest that these indicators could be used in the nutritional and functional assessment of the patients.

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Comparison of absolute and relative handgrip strength to predict cancer prognosis: A prospective multicenter cohort study

Cited by 13 publications

References 25 publications

Predictive value of Global Leadership Initiative on Malnutrition criteria combined with handgrip strength for postoperative outcomes in overweight colorectal cancer patients

Predictive value of Global Leadership Initiative on Malnutrition criteria combined with handgrip strength for postoperative outcomes in overweight colorectal cancer patients

Association between grip strength and stress urinary incontinence of NHANES 2011–2014

Phase Angle, Handgrip Strength, and Other Indicators of Nutritional Status in Cancer Patients Undergoing Different Nutritional Strategies: A Systematic Review and Meta-Analysis

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