Comparison of Acoustic Radiation Force Impulse/Serum Noninvasive Markers for Fibrosis Prediction in Liver Transplant

Pinto, J.; Matos, Hugo; Nobre, Susana; Cipriano, Maria Augusta; Marques, Margarida; Pereira, João; Gonçalves, Isabel; Noruegas, Maria José

doi:10.1097/mpg.0000000000000226

Cited by 39 publications

(34 citation statements)

References 24 publications

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“…There was no overlap in mean shear wave speed measurements between the biliary atresia and non-biliary atresia groups. Our observed shear wave speeds are in general agreement with previously reported values for individuals with and without liver fibrosis [8,9,[26][27][28]. Given the novelty of VTIQ imaging, no previously reported values are available for which to compare our VTIQ results.…”

Section: Discussionsupporting

confidence: 93%

Shear wave elastography helps differentiate biliary atresia from other neonatal/infantile liver diseases

et al. 2014

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Section: Discussionsupporting

confidence: 93%

Shear wave elastography helps differentiate biliary atresia from other neonatal/infantile liver diseases

et al. 2014

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“…Through multivariate logistic regression analysis, the only independent predictor of significant fibrosis was SWV. SWV assessment may serve as a potential method for assessing significant fibrosis in pediatric patients with liver transplants, particularly in combination with AST/ALT ratio [64].…”

Section: Liver Fibrosismentioning

confidence: 99%

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

et al. 2018

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Featured Application: In this review we present and discuss the published literature on the use of ultrasound-based liver elastography in children. The published data show that all the available shear wave elastography techniques are feasible and accurate for the assessment of liver fibrosis in children with diffuse liver disease due to several etiologies. For the assessment of focal liver lesions evidences are limited and no conclusion can be drawn so far.Abstract: Studies performed using transient elastography (TE), point shear wave elastography (pSWE) and two-dimensional shear wave elastography (2D-SWE) have shown that these techniques are all feasible and accurate in children for the evaluation of liver fibrosis due to several etiologies. However, for some specific pediatric pathologies, such as biliary atresia, the evidence is still limited. As shown in adults, inflammation is a confounding factor when assessing fibrosis severity and care should be taken when interpreting the results. Due to the scarce comparative data between serological tests and elastography techniques in children, a definite conclusion regarding which is the best cannot be drawn. Neither non-invasive elastographic techniques nor laboratory scores allow determination of the presence and the degree of inflammation, necrosis, iron or copper deposits.

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“…However, Wildner and associates 4 reported that the areas under the receiver operating characteristic curves for patients with advanced fibrosis (F3) and cirrhosis (F4) (by Batts-Ludwig scoring) were 92.9% and 80% and had discretely higher cutoff values (≥ F1, 1.48 m/s). Pinto and associates 22 indicated a statistically significant difference in shear-wave velocities between the F0-F1 and F2-F4 groups (by Batts-Ludwig scoring), concluding that ARFI might serve as a potential method for assessing significant fibrosis in pediatric patients after liver transplant. Tomita and associates 23 reported that the ARFI measurements were significantly higher for patients with F1 and F2 portal fibrosis versus patients with F0 portal fibrosis (by METAVIR scoring).…”

Section: Discussionmentioning

confidence: 99%

“…5,18,[21][22][23] Liao and associates 21 reported a sensitivity ratio of 95.5% using a shear-wave velocity cutoff value of 1.058 m/s in the evaluation of posttransplant graft dysfunction in early fibrosis stages (≤ F1, by METAVIR scoring); which constituted a larger proportion of the study group (94.5%). The group indicated that there was a significant difference in F0 compared with F1.…”

Section: Discussionmentioning

confidence: 99%

Liver Stiffness Measurements Using Acoustic Radiation Force Impulse in Recipients of Living-Donor and Deceased-Donor Orthotopic Liver Transplant

Haberal

Turnaoğlu²,

Özdemır³

et al. 2021

Exp Clin Transplant

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Objectives: The aim of this study was to evaluate the diagnostic efficiency of the acoustic radiation force impulse (Siemens Medical Solutions, Erlangen, Germany) elastography in assessment of fibrosis in orthotopic liver transplant patients. Materials and Methods:We enrolled 28 orthotopic liver transplant patients (deceased and living donors), whose biopsy decision had been prospectively given clinically. Ten acoustic radiation force impulse elastographic measurements were applied before the biopsy or within 3 days after the biopsy by 2 radiologists. After the core tissue needle biopsy, specimens of all patients were analyzed according to the modified Ishak scoring system. Measurements of acoustic radiation force impulse elastography and pathology specimen results were compared. Key words: Liver biopsy, Liver fibrosis, Metavir, Transient elastography, Ultrasonography IntroductionLiver transplant is the only treatment option for advanced liver disease. However, after liver transplant, acute complications (including primary dysfunction, hepatic artery thrombosis, portal vein thrombosis, hepatic venous obstruction, bile leak, and biliary stricture) or chronic complications (including chronic rejection, disease recurrence, and drug-induced complications) may occur. 1-3 Posttransplant liver dysfunction can have various causes; evaluation of the causes, which can lead to diffuse parenchymal damage, including fibrosis, is of clinical importance.Postoperative B-mode and Doppler ultrasonography (US) are standard procedures for the assessment of graft complications. From US findings, clinical symptoms, and abnormal laboratory findings, a liver biopsy may be required. 4 Although liver biopsy is the standard method for the assessment of morphologic liver changes and fibrosis, it is an invasive procedure that may cause complications. 5 Transient elastography (TE) is currently the most widely used and endorsed method for the asses sment of liver fibrosis in many conditions, such as chronic hepatitis B and C, nonalcoholic steatohepatitis, and nonalcoholic fatty liver disease, as well as in posttransplant patients. 6 Insufficient performance in detecting mild fibrosis, failure to measure liver elasticity in patients with obesity, ascites, and narrow intercostal space, and inability to target liver parenchyma by direct visualization are problems that remain a considerable adversity of this tool. 7,8 Acoustic radiation force impulse (ARFI; Siemens Medical Solutions, Erlangen, Germany) elastography is a new technology to measure liver stiffness and

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Comparison of Acoustic Radiation Force Impulse/Serum Noninvasive Markers for Fibrosis Prediction in Liver Transplant

Abstract: ARFI may serve as a potential method for assessing significant fibrosis in pediatric patients with liver transplant, particularly in combination with AST/ALT ratio index.

Cited by 39 publications

References 24 publications

Shear wave elastography helps differentiate biliary atresia from other neonatal/infantile liver diseases

Shear wave elastography helps differentiate biliary atresia from other neonatal/infantile liver diseases

Current Knowledge in Ultrasound-Based Liver Elastography of Pediatric Patients

Liver Stiffness Measurements Using Acoustic Radiation Force Impulse in Recipients of Living-Donor and Deceased-Donor Orthotopic Liver Transplant

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