Comparison of actions of disodium cromoglycate and ketotifen on exercise-induced bronchoconstriction in childhood asthma.

Kennedy, J D; Hasham, Faiz; Clay, Michelle; Jones, Roland M.

doi:10.1136/bmj.281.6253.1458

Cited by 21 publications

(4 citation statements)

References 3 publications

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“…of patients and is thought to work like ketotifen by its mast cell stabilizing properties (Davies, 1968). However, Kennedy et al (1980) using the same dose of 1 0 mg twice daily for 3 days found ketotifen tobecomplctely ineffective in children with EIA. However, Kennedy et al (1980) using the same dose of 1 0 mg twice daily for 3 days found ketotifen tobecomplctely ineffective in children with EIA.…”

Section: Resultsmentioning

confidence: 95%

A comparison of ketotifen with clemastine, ipratropium bromide and sodium cromoglycate in exercise‐induced asthma

Dorward

Patel

1982

Clin Experimental Allergy

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Exercise-induced asthma (EIA) was provoked by a standardized treadmill running for 8 min in seven atopic adult asthmatics. The tests were performed using a doubledummy technique after placebo, oral ketotifen. inhaled clemastine, ipratropium bromide and sodium cromoglycate (SCG), in a random single blind-fashion on different days. The mean post-exercise percentage fall in forced expiratory volume in 1 sec (FEVi) was 47 (s.e. 6-95). 39 (s.e. 8 35). 27 (s.e. 717). 23 (s.e. 769) and 70 (s.e. 4 62)% respectively. There was significantly less mean bronchoconstriction with SCG (/'<001). ipratropium bromide and clemastine (/'<005) but not with ketotifen. Six out of seven individual patients had significant protection of EIA with sodium cromoglycate, four with ipratropium bromide, three with clemastine but only one with ketotifen. Ipratropium bromide and clemastine were bronchodilators at rest, whereas SCG and ketotifen were not. Despite its claims to work as a mast cell stabilizing drug, ketotifen in a single dose does not have an effect similar to sodium cromoglycate in EIA, nor does it compare with inhaled clemastine or ipratropium bromide.

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Section: Resultsmentioning

confidence: 95%

A comparison of ketotifen with clemastine, ipratropium bromide and sodium cromoglycate in exercise‐induced asthma

Dorward

Patel

1982

Clin Experimental Allergy

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“…Isocapnic hyperventilation and exercise have been shown to produce closely correlated degrees of bronchoconstriction (Tweeddale et al, 1981;Deal et al, 1979). Craps et al (1978) reported inhibition of EIA following 4 days of treatment with ketotifen but this effect could not be confirmed by others following ketotifen given in single dose (Dorward & Patel, 1982), for 4 days (Kennedy et al, 1980), for 1 week (Lilja et al, 1983) or for 4 weeks (Petheram et al, 1981). These results might be attributed to inadequate duration of treatment with ketotifen since it has been reported that ketotifen may achieve maximal efficacy only after 5 weeks of treatment (Gobel, 1978).…”

Section: Discussionmentioning

confidence: 99%

Does regular treatment with ketotifen inhibit bronchoconstriction induced by isocapnic hyperventilation?

Rafferty

Tweeddale

Ferguson

et al. 1987

Brit J Clinical Pharma

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“…U, Broberger et a\. significant effect on bronchial hyperreactivity [10] or on exercise-induced asthma (EIA) [11][12][13][14]. However, theefficacy of ketotifen is still under debate [15] and therefore there is a great demand for well-controlled studies that evaluate the clinical effect of ketotifen on bronchial asthma.…”

Section: Introductionmentioning

confidence: 99%

Ketotifen in pollen‐induced asthma: a double blind placebo‐controlled study

Broberger

Graff‐Lonnevig

Lilja

et al. 1986

Clin Experimental Allergy

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Twenty-nine children with an average age of 105 years were studied with respect to the protective effect of ketotifen on pollen-induced bronchial asthma. All of them were sensitive to deciduous tree pollen, the diagnosis being verified by bronchial challenge. The children were stratified in matched pairs and randomly allocated to two treatment groups, placebo or ketotifen 1 mg twice daily. The study was double-blind and was performed during the whole of the deciduous tree pollen season. Daily pollen counts were made, allergic symptoms were noted, additional medication was given and the expiratory pulmonary flow was recorded. During the birch pollen peak the ketotifen group showed significantly fewer, and less severe asthma and rhinoconjunctivitis than the placebo group. The anti-asthmatic medication was also used significantly less than in the placebo group. Ketotifen appeared to have good protective properties in the treatment of pollen-induced asthma and rhinoconjunctivitis.

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Comparison of actions of disodium cromoglycate and ketotifen on exercise-induced bronchoconstriction in childhood asthma.

Cited by 21 publications

References 3 publications

A comparison of ketotifen with clemastine, ipratropium bromide and sodium cromoglycate in exercise‐induced asthma

A comparison of ketotifen with clemastine, ipratropium bromide and sodium cromoglycate in exercise‐induced asthma

Does regular treatment with ketotifen inhibit bronchoconstriction induced by isocapnic hyperventilation?

Ketotifen in pollen‐induced asthma: a double blind placebo‐controlled study

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