Comparison of acute hemodynamic effects of nitroglycerin versus diltiazem and combined acute effects of both drugs in angina pectoris

Hossack, Kenneth F.; Eldridge, Joan E.; Buckner, Kern

doi:10.1016/0002-9149(86)90344-9

Cited by 11 publications

(2 citation statements)

References 9 publications

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“…There have been many studies on nitroglycerin and sodium nitroprusside in ischemia and their hemodynamic effects in hypertensive patients. 12 –19 Breisblatt and colleagues 12 found in a comparative study of nitroglycerin and nitroprusside in acutely ischemic patients that these agents increased cardiac output by 28% and 35%, respectively, whereas there was a decrease in MAP of 10% and 13% for each drug. Ejection fraction increased by 0.13% with nitroglycerin and by 0.17% with nitroprusside.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Antihypertensives after Coronary Artery Surgery

Toraman

Karabulut

Göksel

et al. 2005

Asian Cardiovasc Thorac Ann

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Hypertension following coronary artery bypass grafting is a common problem that may result in postoperative myocardial infraction or bleeding, Hemodynamic effects were compared in 45 hypertensive coronary bypass patients randomized to receive either diltiazem, nitroglycerin, or sodium nitroprusside. Diltiazem was administered as an intravenous bolus of 0.3 mg.kg-1 within 5 min, followed by infusion of 0.1-0.8 mg.kg-1.h-1 in group 1. Nitroglycerin was infused at a rate of 1-3 microg.kg.h-1 in group 2, and sodium nitroprusside was given at a rate of 1-3 microg.kg-1.min-1 in group 3. Hemodynamic measurements were carried out before infusion (T1) and at 30 min (T2), 2 h (T3), and 12 h (T4) after initiation of treatment in the intensive care unit. Mean arterial pressure decreased significantly in all groups. There were no differences among groups at T1 and T2. At T3, heart rate in group 2 was significantly higher than group 1. At T3 and T4, the double product was highest in group 3 (group 1 vs. 3, p<0.001). These results suggest that the hemodynamic effects of the 3 drugs are similar within the first 30 min. However, after 30 min, diltiazem affords better myocardial performance and more effective control of hypertension.

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Section: Discussionmentioning

confidence: 99%

Comparison of Antihypertensives after Coronary Artery Surgery

Toraman

Karabulut

Göksel

et al. 2005

Asian Cardiovasc Thorac Ann

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“…Both drugs are well established in the treatment of patients with coronary artery disease and both have been shown to be highly efficient in the reduction of myocardial ischemia 156 '. Calcium antagonists and nitrates are often combined in the daily routine for an optimal anti-ischaemic effect in patients with angina pectoris although clinical trials did not show a better result for the combined regimen than for either drug alone' 6 '. Thus, the purpose of the present study was to evaluate the effect of diltiazem alone and combined with sublingual nitroglycerin on coronary vasomotion of normal and stenotic coronary arteries at rest and during dynamic exercise in patients with exerciseinduced ischaemia.…”

Section: Discussionmentioning

confidence: 99%

Diltiazem alone and combined with nitroglycerin: effect on normal and diseased human coronary arteries

Hess¹,

Nonogi²,

Bortone³

et al. 1989

European Heart Journal

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Normal vessel: In the control group luminal area increased significantly during exercise (+23%, P < 0-01) and after sublingual administration of nitroglycerin (+40%, P < 0001). In group 2 luminal area increased after intracoronary administration of diltiazem (+19%, P<0-01), during bicycle exercise (+23%, P<0-001) and after sublingual administration of nitroglycerin (+39%, P <0001). Stenotic vessel: In the control group luminal area decreased significantly (-29%, P < 0-001) during bicycle exercise but increased after sublingual administration of nitroglycerin at the end of the exercise test (+12%, NS vs. rest). In group 2 intracoronary administration of diltiazem was associated with a mild increase in stenosis area (+11%, P <0-05). There was a further increase in stenosis area during bicycle exercise (+23%, P <0001 vs. rest) and after sublingual nitroglycerin (+32%, P<0001).Coronary vasodilation of the stenotic segment was, however, significantly more pronounced after sublingual nitroglycerin in group 2 than 1 (+32% versus 12%, P <0-05 Introduction haemodynamic variables such as heart rate,

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Combined Treatment of Stable Effort-Induced Angina and Mixed Angina

Egstrup

1990

Pathophysiology and Rational Pharmacotherapy of Myocardial Ischemia

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Comparison of acute hemodynamic effects of nitroglycerin versus diltiazem and combined acute effects of both drugs in angina pectoris

Cited by 11 publications

References 9 publications

Comparison of Antihypertensives after Coronary Artery Surgery

Comparison of Antihypertensives after Coronary Artery Surgery

Diltiazem alone and combined with nitroglycerin: effect on normal and diseased human coronary arteries

Combined Treatment of Stable Effort-Induced Angina and Mixed Angina

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