1960
DOI: 10.1001/jama.1960.03020080009004
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Comparison of Acute Hypoglycemic Potencies of Tolbutamide and Chlorpropamide

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1961
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Cited by 3 publications
(2 citation statements)
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“…A double-blind trial showing an increase in clinically 'good' responses to tolbutamide rather than placebo (Hurwitz & McCuistion 1957) showed that tolbutamide is effective, whatever the mechanism. Craig et al (1960) showed similar acute hypoglycaemic potencies in diabetic subjects when tolbutamide and chlorpropamide were given intravenously. However, studies using the intravenous route ignore differences in absorption and elimination kinetics, and McMahon et al (1962) defined the clinical potency of the two agents as 1 : 4 to 1 : 7, roughly in line with the ratio of the halflives as then accepted.…”
Section: Relevant Pharmacodynamicsmentioning
confidence: 76%
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“…A double-blind trial showing an increase in clinically 'good' responses to tolbutamide rather than placebo (Hurwitz & McCuistion 1957) showed that tolbutamide is effective, whatever the mechanism. Craig et al (1960) showed similar acute hypoglycaemic potencies in diabetic subjects when tolbutamide and chlorpropamide were given intravenously. However, studies using the intravenous route ignore differences in absorption and elimination kinetics, and McMahon et al (1962) defined the clinical potency of the two agents as 1 : 4 to 1 : 7, roughly in line with the ratio of the halflives as then accepted.…”
Section: Relevant Pharmacodynamicsmentioning
confidence: 76%
“…The acute hypoglycaemic potency in normal subjects is similar to (McMahon et al 1962), or greater than (West & McCampbell 1959) that of tolbutamide. The doseresponse curves for serum drug concentration and absolute fall in blood glucose, were very similar in a crossover study of hypoglycaemic potency in 17 diabetic subjects (Craig et al 1959), although the drug assays used were not specific for active drugs (table II). Knauff et al (1959) produced very interesting data showing a relationship between absolute fasting concentration of chlorpropamide in 2 normal subjects and the relative decrease in the fasting glucose concentration.…”
Section: Relevant Pharmacodynamicsmentioning
confidence: 88%