Comparison of ADC values in different malignancies of the skeletal musculature: a multicentric analysis

Surov, Alexey; Nagata, Shuji; Razek, Ahmed A. Abd; Tirumani, Sree Harsha; Wienke, Andreas; Kahn, Thomas

doi:10.1007/s00256-015-2141-5

Cited by 65 publications

(44 citation statements)

References 17 publications

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“…DWI is an imaging modality sensitive to tissue alterations in several muscle disorders (Surov et al., ). For example, it has been shown that DWI correlates with cellularity in several tumors (Surov et al., ).…”

Section: Discussionmentioning

confidence: 99%

“…For example, it has been shown that DWI correlates with cellularity in several tumors (Surov et al., ). Moreover, ADC values are significantly different between several muscle tumors reflecting various cellularity in muscle tumors (Surov & Behrmann, ; Surov et al., , ).…”

Section: Discussionmentioning

confidence: 99%

“…DWI is an imaging modality sensitive to tissue alterations in several muscle disorders (Surov et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, diffusion-weighted imaging (DWI) has been evaluated to be a useful imaging tool in several muscle disorders such as tumors, inflammation, and myopathies (Partovi et al, 2015;Qi, Olsen, Price, Winston, & Park, 2008;Ran et al, 2016;Surov & Behrmann, 2014;Surov et al, 2015). Additionally, it can be quantified with the apparent diffusion coefficient (ADC) reflecting the random water motion in tissue (Surov, Meyer, & Wienke, 2017).…”

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confidence: 99%

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Associations between apparent diffusion coefficient and electromyography parameters in myositis—A preliminary study

Meyer¹,

Emmer

Kornhuber

et al. 2018

Brain and Behavior

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Objective MRI is widely used in several muscle disorders. Diffusion‐weighted imaging (DWI) is an emergent imaging modality sensitive to microstructural alterations in tissue. The apparent diffusion coefficient (ADC) is used to quantify the random motion of water molecules. Electromyography (EMG) is a clinically used diagnostic tool in myositis. The aim of this study was to elucidate possible associations between ADC values and EMG findings in myositis patients.MethodSeven patients (eight investigated muscles) with myositis (mean age 51.43 ± 19 years) were included in this study. The diagnosis was confirmed by histopathology in every case. DWI was obtained with a 1.5‐T scanner using two b‐values 0 and 1000 s/mm². In all patients, a needle electromyography (EMG) was performed within 3 days to the MRI. The following EMG parameters were studied: motor unit action potential (MUAP) amplitudes and durations, as well as pathological spontaneous activity. Spearman's correlation coefficient was used to analyze associations between investigated parameters.ResultsThe estimated mean ADC mean value was 1.51 ± 0.29 × 10−3 mm²/s, mean ADC min was 1.28 ± 0.27 × 10−3 mm²/s, and mean ADC max was 1.73 ± 0.28 × 10−3 mm²/s. Correlation analysis identified significant associations between ADC mean and duration of the MUAP (p = .78 P = .0279) and between ADC min and duration of the MUAP (p = .85, P = .01). There were no significant differences according to pathological spontaneous activity.Conclusion ADC mean and ADC min showed strong positive correlations with the duration of the MUAP in myositis patients. Both modalities might similarly reflect muscle fiber loss in myositis patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…DWI is an imaging modality sensitive to tissue alterations in several muscle disorders (Surov et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Associations between apparent diffusion coefficient and electromyography parameters in myositis—A preliminary study

Meyer¹,

Emmer

Kornhuber

et al. 2018

Brain and Behavior

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“…In contrast, another study showed that there was no significant difference in ADC values between benign and malignant tumors [14]. Surov et al [15] reported that diffusion is determined by the balance between matrix and cellularity, but not the dignity of the lesion. Evaluation with diffusion-weighted MRI may be useful for differentiating chondroid lipoma from sarcoma.…”

Section: Discussionmentioning

confidence: 99%

Chondroid lipoma of the neck: a case report

et al. 2018

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BackgroundChondroid lipoma, first described in 1993 by Meis and Enzinger, is a very rare lipomatous tumor. Because it is a benign tumor, it does not require radiotherapy, chemotherapy, or extensive resection. However, histologically, it is often confused with a sarcoma. It is crucial to differentiate chondroid lipoma from sarcoma to avoid choosing an inappropriate treatment strategy. Although MRI, radiography, and ultrasound have been used to evaluate chondroid lipomas, imaging cannot accurately differentiate chondroid lipoma from sarcoma.Case presentationA 39-year-old man presented to a local clinic with a 1-month history of a painless mass in his left neck. Results of a needle biopsy suggested an atypical lipomatous tumor, and the patient was referred to our hospital. Physical examination revealed a hard and mobile mass in the left neck. Plain X-ray radiographs showed an absence of calcification in the soft tissue mass. MRI revealed a well-defined and lobulated mass, and on T1-weighted images, the lesion showed heterogeneity, with higher signal intensity than that of muscle. On T2-weighted images, the septum had low-signal intensity. On T2-weighted fat-suppressed images, the signal of the mass was completely suppressed. The SUVmax of the mass on FDG PET was 1.84. An additional needle biopsy was performed, and on the basis of the results, we arrived at a diagnosis of well-differentiated liposarcoma. The mass was resected marginally. Macroscopically, the mass was encapsulated and markedly harder than well-differentiated liposarcoma. Histologically, the tumor was composed of myxoid and cartilaginous matrix, and mature fat cells and lipoblast-like cells were present. The final diagnosis was chondroid lipoma, and no recurrence was observed 1 year after surgery.ConclusionsChondroid lipoma is an extremely rare benign soft tissue tumor that is often confused with sarcoma. It is very important to differentiate chondroid lipoma from sarcoma when the SUVmax value of the mass is low, even when biopsy results suggest that it is a sarcoma.

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Associations between apparent diffusion coefficient values and histopathological tissue alterations in myopathies

Meyer¹,

Schneider

Emmer

et al. 2020

Brain and Behavior

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Comparison of ADC values in different malignancies of the skeletal musculature: a multicentric analysis

Cited by 65 publications

References 17 publications

Associations between apparent diffusion coefficient and electromyography parameters in myositis—A preliminary study

Associations between apparent diffusion coefficient and electromyography parameters in myositis—A preliminary study

Chondroid lipoma of the neck: a case report

Associations between apparent diffusion coefficient values and histopathological tissue alterations in myopathies

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