Comparison of adenocarcinoma and squamous cell carcinoma of the uterine cervix: A population-based epidemiologic study

Anton‐Culver, Hoda; Bloss, Jeffrey D.; Bringman, Deborah; Lee-Feldstein, Anna; DiSaia, Philip J.; Manetta, Alberto

doi:10.1016/0002-9378(92)91627-m

Cited by 67 publications

(18 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is a relative increase mainly due to efficient cervical cytologic screening for preinvasive squamous dysplasia leading to a lower incidence of squamous cell carcinoma. There are figures ranging from 6% in the 1950s to 26% in the 1990s in different studies ( 3 , 10 , 17 –20 ) . Adenocarcinoma also varies in different reports due to different histologic classification and selected materials looking at a single stage or treatment modality.…”

Section: Discussionmentioning

confidence: 99%

Survival of patients with adenocarcinoma of the uterine cervix in western Sweden

WaldenstrÖm

Horváth

1999

Int J Gynecol Cancer

View full text Add to dashboard Cite

Survival in adenocarcinoma of the uterine cervix varies between different reports. In our study the patients have been treated in a similar way as those with squamous cell carcinoma. One hundred twenty-one adenocarcinomas were diagnosed between 1987 and 1994 in the West Sweden Health Care Region. One hundred of the patients with adenocarcinoma were treated at Sahlgrenska University Hospital and studied retrospectively. The median age was 54 years (range 27-91). Histopathologic differentiation was relatively evenly distributed between well (34%), intermediately (38%), and poorly differentiated (28%). All FIGO stages were represented, but stage I predominated (65%). Depending mainly on tumor stage and age, the patients had either surgery, surgery + radiotherapy, or radiotherapy only. In our study, the five-year survival for adenocarcinoma was 64% and for squamous/adenosquamous carcinoma was 66% (NS). The five-year survival for different stages of adenocarcinomas was for stage I 86%, stage II 38%, stage III 23%, and stage IV 0%, the difference between stage I and stage II being highly significant. Treated in a similar way, the five-year survival for adenocarcinoma is equal to that for squamous/adenosquamous carcinoma in our study.

show abstract

Section: Discussionmentioning

confidence: 99%

Survival of patients with adenocarcinoma of the uterine cervix in western Sweden

WaldenstrÖm

Horváth

1999

Int J Gynecol Cancer

View full text Add to dashboard Cite

show abstract

“…530,232 new cases are diagnosed and 275,008 women die of ICC worldwide annually . The proportion of adenocarcinoma in ICC varies between countries and has risen from approximately 5% to 27% in some countries . The reported prevalence of HPV DNA in cervical adenocarcinoma varies from 32% to 100% .…”

Section: Adjudicating Diagnostic Algorithm For Cases With Inconsistenmentioning

confidence: 99%

“…1 The proportion of adenocarcinoma in ICC varies between countries and has risen from approximately 5% to 27% in some countries. [2][3][4][5] The reported prevalence of HPV DNA in cervical adenocarcinoma varies from 32% to 100%. 6 Many explanations have been offered, including sensitivity of HPV detection, quality and size of samples examined and accuracy of pathological diagnosis.…”

mentioning

confidence: 99%

The variable clinicopathological categories and role of human papillomavirus in cervical adenocarcinoma: A hospital based nation‐wide multi‐center retrospective study across China

Chen

Molijn

Enqi

et al. 2016

Intl Journal of Cancer

View full text Add to dashboard Cite

We investigated HPV in adenocarcinoma presenting and managed as cervical adenocarcinoma (CADC) at seven major representative regional cancer centres across China. From 1,051 CADC cases diagnosed locally in 2005-2010, 881 had available paraffin embedded tissue. Initial review excluded 154 cases as other diagnoses or inappropriate specimens. In 718 eligible cases consensus panel pathology diagnosis was made using an algorithm incorporating p16 and progesterone receptor immunohistochemistry (IHC). Classification of cervical adenocarcinoma categories was subject to substantial pathological disagreement. High-risk human papillomaviruses (HR-HPV) DNA was studied by the sensitive SPF10 PCR-DEIA-LiPA25 version 1 for L1 genes and type-specific HR-HPV E6/7 gene PCR's. HR-HPV prevalence in whole tissue samples in eligible tested CADC was 74.5%: 100.0% in neuro-endocrine carcinoma (NEC), 82.2% in classical cervical adenocarcinoma (ADC-CX), 40.0% in adenocarcinoma-not otherwise specified (ADC-NOS) and 33.3% in endometrioid adenocarcinoma (ADC-ENDO). Higher mean age at diagnosis correlated with histological categories showing low HPV prevalence (Linear regression: β= -13.794, p < 0.001). HPV-16 and 18 were associated with early development of CADC and a lower mean age correlated with carcinogenic risk of associated HPV (β = -0.1829, p < 0.001). HPV-16 or HPV-18 was found in 88.2% of all HPV positive cases including multiple-infections. HPV-18 was the commonest HPV type in NEC (58.3%), ASC (40.2%) and ADC-CX (40.9%). The proportion of HPV-unrelated CADC and in different final histological categories varied geographically and by age. Although HPV negativity was predominantly associated with special categories of CADC, some HPV-negative usual adenocarcinomas indistinguishable by adjudicated microscopic diagnosis from ADC-CX were found and varied in frequency across China.

show abstract

“…In addition, in examining age trends using incidence data, Eide (4) found that the rate of increase with age is almost identical for both histologic types prior to age 34 but that, subsequently, squamous cell carcinoma exhibits a moderate decline in the oldest part of the population whereas the incidence rates for adenocarcinoma were about the same for all ages above 45 years. Such trends, however, were not observed by Anton-Culver et al (9) , who found continued rates of increase with age for both histologic types.…”

mentioning

confidence: 52%

Age-period-cohort analysis of cervical cancer incidence in Taiwan: differences between squamous cell carcinoma and adenocarcinoma

Wang¹,

Lin

1997

Int J Gynecol Cancer

View full text Add to dashboard Cite

To examine the etiologic distinction between squamous cell carcinoma and adenocarcinoma of the cervix, the relationship between the incidence of both histotypes of cancer and age at diagnosis, time period at diagnosis and birth cohort was analyzed using data from the Taiwan Cancer Registry. Included in the study were all cases of both histotypes occurring during the period 1979–90 within a population of Taiwanese women aged 25 to 75 years. A log‐linear model modified from the method of Osmond and Gardner was used for the analyses. Age‐period‐cohort analyses of age effect indicated that, prior to the age group of 49–51, there is an almost identical incidence of both histotypes with an approximate linear trend of age effect but that, after this time, there is a divergence, with the age effect of increase slightly declining with age for squamous cell carcinoma and clearly declining for adenocarcinoma. In regard to period and cohort effects, a substantial moderation of squamous cell carcinoma risk was exhibited with both advancing recent calendar periods and birth cohorts, while adenocarcinoma risk also has a moderation but to a lesser extent. The model also identified the changes in female sex hormones after the menopause as a determinant of the differing age effects, the efficiency of Pap smear screening practices as a determinant of the differing period effects, and changes in reproductive patterns as a determinant of the differing cohort effects. These findings may provide clues with which to develop etiologic hypotheses and support the contention of etiologic distinctions between both histologic types.

show abstract

Comparison of adenocarcinoma and squamous cell carcinoma of the uterine cervix: A population-based epidemiologic study

Cited by 67 publications

References 9 publications

Survival of patients with adenocarcinoma of the uterine cervix in western Sweden

Survival of patients with adenocarcinoma of the uterine cervix in western Sweden

The variable clinicopathological categories and role of human papillomavirus in cervical adenocarcinoma: A hospital based nation‐wide multi‐center retrospective study across China

Age-period-cohort analysis of cervical cancer incidence in Taiwan: differences between squamous cell carcinoma and adenocarcinoma

Contact Info

Product

Resources

About