2006
DOI: 10.1016/j.imlet.2005.10.017
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Comparison of amino acid compositions of peptides eluted from HLA-B27 molecules of healthy individuals and patients with ankylosing spondylitis

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Cited by 5 publications
(3 citation statements)
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References 38 publications
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“…In addition to Plasmodium, many other pathogens, such as Babesia gibsoni (56), Entamoeba histolytica (57), Pneumocystis carinii, and Mycobacterium tuberculosis (58), also have immunogenic glutamate-rich proteins, and some of them were evaluated as new diagnostic tools or vaccine candidates. Additionally, many allergens from plants (59)(60)(61) and some self-antigens that lead to autoimmune disease (62,63) were also glutamate-rich antigens. Thus, it is likely that there are many glutamate-rich proteins that are highly immunogenic in various pathogen species, especially in parasites.…”
Section: Discussionmentioning
confidence: 99%
“…In addition to Plasmodium, many other pathogens, such as Babesia gibsoni (56), Entamoeba histolytica (57), Pneumocystis carinii, and Mycobacterium tuberculosis (58), also have immunogenic glutamate-rich proteins, and some of them were evaluated as new diagnostic tools or vaccine candidates. Additionally, many allergens from plants (59)(60)(61) and some self-antigens that lead to autoimmune disease (62,63) were also glutamate-rich antigens. Thus, it is likely that there are many glutamate-rich proteins that are highly immunogenic in various pathogen species, especially in parasites.…”
Section: Discussionmentioning
confidence: 99%
“…36 HLA B27 molecules have also been proved to be rich in proline. 37 This might potentially be another source of the higher blood proline content in the AS population. Hyperhomocysteinemia is usually associated with rheumatic diseases, partially due to vitamin dysmetabolism.…”
Section: Biological Significance Of the Altered Metabolites In Asmentioning
confidence: 99%
“…7 According to reports, the immune effects that occurred in collagen tissue may lead to excessive breakdown of collagen components, thereby increasing the circulating proline in the blood. 9 It is also worth noticing that HLA-B27 molecules have been proven to be rich in proline, 10 and the HLA-B27 positivity has been widely used in clinical practice to identify SpA. 11,12 What's more, unpaired cysteine residues in HLA antigens can be directly or indirectly modified by homocysteine and then subsequently disrupted by abnormal autoimmune reactions, which is also considered a mechanism of AS associated with HLA-B27.…”
Section: Introductionmentioning
confidence: 99%