Comparison of amino acids interaction with gold nanoparticle

Ramezani, Fatemeh; Amanlou, Massoud; Rafii-Tabar, Hashem

doi:10.1007/s00726-013-1642-6

Cited by 43 publications

(26 citation statements)

References 52 publications

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“…This is exactly what has been suggested by many authors for this amino acid when it is added in relatively high concentration with respect to the surface Au atoms. Thus our findings do not contradict previous reports not only for Cys but also for other amino acids like those indicating that Asp binds to AuNPs and can act as crosslinking agent . In any case, the different behavior of the amino acids allows the precise identification of five of them (Figure ) at very low concentration (ca., 4 µM).…”

Section: Discussionsupporting

confidence: 68%

“…The presence of typically two or three different functional groups on each amino acid provides a high variability to the possible binding modes between each of them and the surface of gold nanoparticles. Because of this, there is not a unified mode of binding for amino acids to AuNPs as this depends not only on the structure of the single amino acid but also on the experimental conditions and the additional passivating agent present on the nanoparticle surface . The picture is even less clear when the interaction is with small peptides as most of the studies are confined to thiolated systems as those comprising in their sequence cysteine (Cys) or homocysteine, for instance.…”

Section: Introductionmentioning

confidence: 99%

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Gold nanoparticles crosslinking by peptides and amino acids: A tool for the colorimetric identification of amino acids

Martínez

Scrimin

2018

Biopolymers

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Gold nanoparticles are known to aggregate in the presence of proper multifunctional compounds. For those larger than 3 nm, the process can be followed with the naked eye because the surface plasmon absorption band of the particles shifts to longer wavelengths and the solution color changes from red to blue. To exploit this property, we have used amino acids and peptides as crosslinking agents in ethanol at low µM concentrations. In the case of amino acids, we report a straightforward protocol for their colorimetric identification. We also report that the presence of precise secondary structure and conformational constraints in oligopeptides, directly influence their crosslinking ability. A discussion on the nature of the interactions that induce these phenomena is also reported.

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Section: Discussionsupporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles crosslinking by peptides and amino acids: A tool for the colorimetric identification of amino acids

Martínez

Scrimin

2018

Biopolymers

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“…In the last paper published by our group we showed mono amino acids conformations after adsorption on the GNP surface [ 9 ]. Our results for Met, Cys, Pro, Phe, Gly and Leu were matched with the experimental results reported by Podstawka et al In the current work we found di and tri- amino acids conformation after adsorption on the gold surface.…”

Section: Resultsmentioning

confidence: 99%

“…GNP kept its cubic shape after 10 ns simulation time. In a previous study by our group, the effect of the size of nanoparticle was examined and it was found that the cubic nanoparticle size makes no difference on the interaction of amino acids [ 9 ]. So in this study GNP size was considered 3 nm.…”

Section: Methodsmentioning

confidence: 99%

“…They showed peptides dynamic and structure depends on the amino acids sequence. In the last paper our group compared 20 natural amino acids interaction with gold nanoparticle by molecular dynamic [ 9 ]. Next, we continue to understand the impact of peptide lengths on their adsorption, their flexibility and stability while interacting with GNPs from the molecular level point of view.…”

Section: Introductionmentioning

confidence: 99%

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Effect of peptide length on the conjugation to the gold nanoparticle surface: a molecular dynamic study

et al. 2015

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BackgroundGold nanoparticles now command a great deal of attention for medical applications. Despite the importance of nano-bio interfaces, interaction between peptides and proteins with gold surfaces is not still fully understood, especially in a molecular level.MethodsIn the present study computational simulation of adsorption of 20 amino acids, in three forms of mono-amino acid, homo di-peptide and homo tri-peptide, on the gold nanoparticles was performed by Gromacs using OPLSAA force field. The flexibility, stability, and size effect of the peptides on the gold nanoparticles were studied as well as the molecular structure of them.ResultsAccording to our results, adsorbed homo tri-peptides on the gold surface had more flexibility, more gyration, and the farthest distance from the GNP in comparison with homo di-peptides and mono-amino acids.ConclusionOur findings provide new insights into the precise control of interactions between amino acids anchored on the GNPs.Electronic supplementary materialThe online version of this article (doi:10.1186/s40199-014-0085-2) contains supplementary material, which is available to authorized users.

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Recent Developments on Optical Aptasensors for the Detection of Pro‐Inflammatory Cytokines with Advanced Nanostructures

Borg,

Ho,

Zeng

2024

Advanced Optical Materials

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In the realm of immune response, pro‐inflammatory cytokines play a crucial role in regulating various physiological functions. Accurate measurement of these low‐molecular‐weight proteins is essential for understanding immune function, predicting diseases, and monitoring treatment effects. Optical aptasensors with advanced nanostructures, which utilize aptamers as bio‐probes, have emerged as a promising technology for cytokine detection, offering advantages over traditional antibody‐based nanobiosensors. Aptamers, single‐stranded nucleic acids with high specificity and affinity, enable cost‐effective mass production and consistent quality. Optical biosensors incorporating aptamers exhibit stability, resistance to environmental factors, and prolonged functionality. This review explores the current methodologies and advancements in optical aptasensors for cytokine detection, highlighting their potential as robust tools in diagnostics and therapeutics. Specifically, the applications of surface plasmon resonance and fluorescence techniques in aptasensors are discussed, focusing on the innovative approaches used to enhance sensitivity and specificity in cytokine detection. Notable examples of aptasensor designs utilizing nanoparticles, Förster resonance energy transfer, and amplification strategies are presented. These designs demonstrate high affinity, specificity, and improved sensitivity in detecting pro‐inflammatory cytokines such as interferon gamma. Overall, optical aptasensors show great promise in advancing the understanding of cytokine‐related disorders and enabling effective interventions.

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Comparison of amino acids interaction with gold nanoparticle

Cited by 43 publications

References 52 publications

Gold nanoparticles crosslinking by peptides and amino acids: A tool for the colorimetric identification of amino acids

Gold nanoparticles crosslinking by peptides and amino acids: A tool for the colorimetric identification of amino acids

Effect of peptide length on the conjugation to the gold nanoparticle surface: a molecular dynamic study

Recent Developments on Optical Aptasensors for the Detection of Pro‐Inflammatory Cytokines with Advanced Nanostructures

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