Comparison of an antifungal agent with a mixture of antifungal, antibiotic and corticosteroid agents for the treatment of Malassezia species otitis in dogs

Abstract

Twenty dogs with otitis externa in both ears and numerous Malassezia species yeasts on cytological examination were treated in one ear with a combination product containing clotrimazole, marbofloxacin and dexamethasone, and in the other ear with a topical antifungal containing miconazole. The effects of the treatments were analysed on the basis of the scores for pruritus, erythema and amount of cerumen, and the number of yeasts on cytological smears. There were reductions in the counts of Malassezia species after both treatments, but the combination product gave significantly greater reductions in erythema, cerumen and pruritus.

Impact of a terbinafine–florfenicol–betamethasone acetate otic gel on the quality of life of dogs with acute otitis externa and their owners

“…In the veterinary literature, there are several studies investigating the clinical efficacy of antibiotic/antifungal/corticosteroid combination ear products, but none of them have used the validated otitis scoring scale OTI‐3, pruritus VAS scale or the semiquantitative cytology scale described by Budach & Mueller, so that comparisons are not possible . Although some of these studies used an otic cytology scale described by Ginel et al ., we preferred to use the one by Budach & Mueller because it has been validated independently .…”

A pilot study to develop an objective clinical score for canine otitis externa

“…The Otitis Index Score (OTIS) scales were designed to assess the severity of the otitis and the response to therapy. They included 0–3 (OTIS3) and 0–5 (OTIS5) assessments of clinical parameters derived by the authors from their clinical experience and previously published studies . The US2 score was included as a reference scale because it is a clinical scoring system for otitis externa used by the US Food and Drug Administration when evaluating veterinary products for regulatory purposes.…”

Otitis externa und media bei Hund und Katze

“…Die meisten Produkte zur topischen Anwendung beinhalten mehrere aktive Ingredienzien (antibakteriell, antifungal und antiinflammatorisch) sowie ein Vehikel und verschiedene Stabilisatoren. Durch diese Kombination wird in vielen Fällen der multifaktoriellen primären und sekundären Genese der akuten Otitis Rechnung getragen und daher oft ein guter Erfolg erzielt (7,74). Anders verhält es sich mit multiresistenten Keimen, bei denen lizensierte Ohrmedikamente vielfach keine Wirkung mehr zeigen.…”