Comparison of an Azobound Amino Salicylate (Olsalazine) vs. A Coated Aminosalicylate (Mesalamine) for Active Ulcerative Colitis

Gastrointestinal spread of oral prolonged‐release mesalazine microgranules (Pentasa) dosed as either tablets or sachet

“…However, higher dosages of mesalazine are now being utilized to treat inflammatory bowel disease, as clinical trials have demonstrated greater efficacy at higher dosages in both ulcerative colitis (2–4 g/day) 11 –14 and Crohn’s disease (2–4 g/day) 15 , . 16 The 250 mg Pentasa tablet has been available since 1986 and the 500 mg preparation since 1990 in many European countries.…”