Comparison of an expiratory flow accelerator device versus positive expiratory pressure for tracheobronchial airway clearance after lung cancer lobectomy: a preliminary study

Rotolo, Nicola; Cattoni, Maria; D’Andria, Michele; Cavanna, Laura; Patrizio, Giorgia; Imperatori, Andrea; Nicolini, Antonello

doi:10.1016/j.physio.2019.01.011

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…Twelve studies (13%) measured all four of the symptoms within the SC. [21,23,24,28,33,35,41,43,45,51,54,60,61,68,72,79,82,83,85,87], two studies were performed at home or in the community setting [67,78], and eight exercise interventions were conducted both in the hospital and at home [22,25,26,29,36,42,58,94]. Te exercise interventions were delivered preoperatively [23,35,36,42,43], postoperatively [21, 22, 24-26, 29, 58, 72, 78, 82, 85], or both pre-and postoperatively [28,33,41,45], during [74] or after radiotherapy [82,83], during [51,54,60,61,67,…”

Section: Study Characteristicsmentioning

confidence: 99%

Nonpharmacological Interventions for Managing the Dyspnea-Fatigue-Physical/Role Functioning Symptom Cluster in Lung Cancer Patients: A Systematic Review

Leyns,

Van Boterdael,

Baele

et al. 2024

European Journal of Cancer Care

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Objective. Lung cancer (LC) patients suffer from multiple cooccurring symptoms. Interventions that have the potential to impact more than one symptom within a symptom cluster should be identified. The aim of this review was to examine nonpharmacological interventions that were effective in the management of one or more of the following symptoms in LC patients: dyspnea, fatigue, physical functioning (PF), and role functioning (RF). Methods. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was used for reporting this systematic review. The Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (using the PubMed interface), Embase (using the embase.com interface), and Web of Science were used as electronic databases. Randomized controlled studies were included if they assessed the effects of nonpharmacological interventions on dyspnea, fatigue, PF, and/or RF in patients with LC. Studies were evaluated with the Cochrane risk of bias tool, and relevant data were extracted and narratively summarized. Results and Conclusions. In total, 89 articles were included. Search results (until April 2023) show that most evidence was found for exercise interventions, followed by multicomponent, psychoeducational, diet, acupuncture, and other interventions. Studies that had an effect on multiple symptoms were observed to have the most frequent instances of positively affecting dyspnea, followed by PF, fatigue, and RF.

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Section: Study Characteristicsmentioning

confidence: 99%

Nonpharmacological Interventions for Managing the Dyspnea-Fatigue-Physical/Role Functioning Symptom Cluster in Lung Cancer Patients: A Systematic Review

Leyns,

Van Boterdael,

Baele

et al. 2024

European Journal of Cancer Care

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“…Lung cancer is a common malignant tumor with high morbidity and mortality, which has attracted wide attention of researchers [ 1 – 4 ]. More and more treatments have been applied to lung cancer, such as surgery, radiation therapy, antibody therapy, and chemotherapy [ 5 – 9 ]. However, the survival rate of patients with lung cancer remains very low, and the five-year survival of these pates less than 25.0% [ 10 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Co-expression of IL-21-Enhanced NKG2D CAR-NK cell therapy for lung cancer

Zhang,

et al. 2024

BMC Cancer

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Background Adoptive cell therapy has achieved great success in treating hematological malignancies. However, the production of chimeric antigen receptor T (CAR-T) cell therapy still faces various difficulties. Natural killer (NK)-92 is a continuously expandable cell line and provides a promising alternative for patient’s own immune cells. Methods We established CAR-NK cells by co-expressing natural killer group 2 member D (NKG2D) and IL-21, and evaluated the efficacy of NKG2D-IL-21 CAR-NK cells in treating lung cancer in vitro and in vivo. Results Our data suggested that the expression of IL-21 effectively increased the cytotoxicity of NKG2D CAR-NK cells against lung cancer cells in a dose-dependent manner and suppressed tumor growth in vitro and in vivo. In addition, the proliferation of NKG2D-IL-21 CAR-NK cells were enhanced while the apoptosis and exhaustion of these cells were suppressed. Mechanistically, IL-21-mediated NKG2D CAR-NK cells function by activating AKT signaling pathway. Conclusion Our findings provide a novel option for treating lung cancer using NKG2D-IL-21 CAR-NK cell therapy.

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Comparison of an expiratory flow accelerator device versus positive expiratory pressure for tracheobronchial airway clearance after lung cancer lobectomy: a preliminary study

Cited by 2 publications

References 35 publications

Nonpharmacological Interventions for Managing the Dyspnea-Fatigue-Physical/Role Functioning Symptom Cluster in Lung Cancer Patients: A Systematic Review

Nonpharmacological Interventions for Managing the Dyspnea-Fatigue-Physical/Role Functioning Symptom Cluster in Lung Cancer Patients: A Systematic Review

Co-expression of IL-21-Enhanced NKG2D CAR-NK cell therapy for lung cancer

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