Comparison of an Occlusive and a Semi-occlusive Dressing and the Effect of the Wound Exudate upon Keratinocyte Proliferation

Madden, Michael R.; Nolan, Eileen; Finkelstein, J.; Yurt, Roger W.; Smeland, Jane; Goodwin, Cleon W.; Hefton, John M.; Staiano‐Coico, Lisa

doi:10.1097/00005373-198907000-00004

Cited by 145 publications

(68 citation statements)

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“…There is a general consensus that wounds epithelialize better if the wound healing environment is moist. This fact is accepted since the observations by Winter [20] that superficial wounds heal faster under intact blisters and was confirmed in many studies showing that a moist environment leads to less intense and less prolonged inflammation [22], more rapid keratinocyte proliferation and migration [23], earlier keratinocyte differentiation, leading to faster restoration of the cutaneous barrier function [24], increased fibroblast proliferation [25], increased collagen synthesis [26], earlier full-thickness wound contraction [27] and earlier, less prolonged angiogenesis.…”

Section: Discussionmentioning

confidence: 86%

Management of Split-Thickness Skin Graft Donor Sites: A Randomized Controlled Trial of Calcium Alginate versus Polyurethane Film Dressing

et al. 2013

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Background: Split-thickness skin graft (STSG) donor sites sometimes cause more postoperative morbidity for patients than the wound covered with the graft. Yet, there is no consensus on which dressings are best suited to treat these donor sites. Objective: To evaluate two commonly used modern wound dressings in the postoperative healing of STSG donor sites in a prospective randomized controlled trial. Methods: 38 patients were randomly assigned to treatment of an STSG donor site with an alginate dressing or a polyurethane film dressing. The primary outcome measures were postoperative pain scores, secondary outcome variables were time to epithelialization, dressing changes and complications. Results: Postoperative pain on day 1 was significantly lower in the polyurethane film group (2.05 vs. 0.79, p = 0.035) as compared to the alginate group. This difference was not detected on day 5 (0.89 vs. 0.53, p = 0.52). Time to epithelialization did not differ significantly between the two dressing groups. There were more dressing changes in the polyurethane film group and problems with leakage. Conclusion: Whereas film dressings resulted in initially lower pain scores, alginate dressings caused fewer additional dressing changes and less leakage.

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Section: Discussionmentioning

confidence: 86%

Management of Split-Thickness Skin Graft Donor Sites: A Randomized Controlled Trial of Calcium Alginate versus Polyurethane Film Dressing

et al. 2013

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“…In a clinical trial of 30 patients with pressure ulcers, Barr et al (15) found that wounds that were surgically debrided prior to the use of autolytic debridement (delivered via a hydrocolloidalginate dressing) showed a significantly better clinical response than if they received autolytic debridement alone. There are additional reports to suggest that the risk for infection may be reduced through the use of a barrier-type dressing with autolytic properties in contrast to a nonocclusive dressing such as gauze (148,221). Clearly, however, there is a need for more objective study in this area to determine the clinical utility of autolytic and enzymatic debridement both combined with and independent of standard surgical debridement (3).…”

Section: Nonantimicrobial Methods Of Treatmentmentioning

confidence: 99%

Wound Microbiology and Associated Approaches to Wound Management

2001

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The majority of dermal wounds are colonized with aerobic and anaerobic microorganisms that originate predominantly from mucosal surfaces such as those of the oral cavity and gut. The role and significance of microorganisms in wound healing has been debated for many years. While some experts consider the microbial density to be critical in predicting wound healing and infection, others consider the types of microorganisms to be of greater importance. However, these and other factors such as microbial synergy, the host immune response, and the quality of tissue must be considered collectively in assessing the probability of infection. Debate also exists regarding the value of wound sampling, the types of wounds that should be sampled, and the sampling technique required to generate the most meaningful data. In the laboratory, consideration must be given to the relevance of culturing polymicrobial specimens, the value in identifying one or more microorganisms, and the microorganisms that should be assayed for antibiotic susceptibility. Although appropriate systemic antibiotics are essential for the treatment of deteriorating, clinically infected wounds, debate exists regarding the relevance and use of antibiotics (systemic or topical) and antiseptics (topical) in the treatment of nonhealing wounds that have no clinical signs of infection. In providing a detailed analysis of wound microbiology, together with current opinion and controversies regarding wound assessment and treatment, this review has attempted to capture and address microbiological aspects that are critical to the successful management of microorganisms in wounds

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“…HydroTac provides a continuum of hydration that aids wound healing.  Faster wound healing (Winter, 1962;Dyson et al, 1988;Beam et al, 2008)  Promote epithelialisation rate (Winter, 1962;Eaglstein, 2001;Ågren et al, 2001;Varghese et al, 1986;Rubio, 1991;Madden et al, 1989;Wigger-Alberti et al, 2009)  Promote dermal/wound bed healing responses, e.g., cell proliferation, ECM synthesis (Svensjö et al, 2000;Dyson et al, 1992;Mosti, 2013;Korting et al, 2010;Chen et al, 1992;Leung et al, 2010;Field & Kerstein, 1994;Dowsett & Ayello, 2004;Katz et al, 1991)  ReducI can't es scarring (Atiyeh et al, 2003(Atiyeh et al, ,2004O'Shaughnessy et al, 2009;Mustoe & Gurjala, 2011;Tandara et al, 2007;Hoeksema et al, 2013)  Retention of growth factors at wound site (Svensjö et al, 2000;Hackl et al, 2014;Powers et al, 2013;Chen et al, 1992;Attinger et al, 2006;Vogt et al, 1995)  Lower wound infection rates (Kannon & Garret, 1995;Hutchinson & Lawrence, 1991;Lawrence, 1994)  Reduces pain perception (Wiechula, 2003;Metzger, 2004;Leaper et al, 2012;Coutts et al, 2008;Feldman, 1991;...…”

Section: Resultsmentioning

confidence: 99%

Wound bed preparation: A novel approach using HydroTherapy

Atkin

Ousey

2016

Br J Community Nurs

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Wounds that fail to heal quickly are often encountered by community nursing staff. An important step in assisting these chronic or stalled wounds progress through healing is debridement to remove devitalised tissue, including slough and eschar, that can prevent the wound from healing. A unique wound treatment called HydroTherapy aims to provide an optimal healing environment. The first step of HydroTherapy involves HydroClean plus™, this dressing enables removal of devitalised tissue through autolytic debridement and absorption of wound fluid. Irrigation and cleansing provided by Ringer's solution from the dressing further removes any necrotic tissue or eschar. Once effective wound bed preparation has been achieved a second dressing, HydroTac™, provides an ongoing hydrated wound environment that enables re-epithelialisation to occur in an unrestricted fashion. This paper presents 3 case studies of slow healing wounds treated with HydroClean plus™ which demonstrates effective wound debridement.

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Comparison of an Occlusive and a Semi-occlusive Dressing and the Effect of the Wound Exudate upon Keratinocyte Proliferation

Cited by 145 publications

References 0 publications

Management of Split-Thickness Skin Graft Donor Sites: A Randomized Controlled Trial of Calcium Alginate versus Polyurethane Film Dressing

Management of Split-Thickness Skin Graft Donor Sites: A Randomized Controlled Trial of Calcium Alginate versus Polyurethane Film Dressing

Wound Microbiology and Associated Approaches to Wound Management

Wound bed preparation: A novel approach using HydroTherapy

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