Comparison of anesthetic agents on otoacoustic emissions in children: propofol vs ketamine

Güngör, Günay; Bozkurt, Pervin; Yener, Murat; Yılmaz, Yetkin Zeki; Sarı, Elif; Ataş, Ahmet; Yılar, Selma; Hayır, Duygu

doi:10.1111/pan.12936

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…Propofol is a short‐acting intravenous anaesthetic reagent that is widely used for sedation and hypnosis during and after operation . It has advantages over other anaesthetic drugs by protecting the immune system from being inhibited, and neuron cells from oxidative stress and hypoxia injury .…”

Section: Introductionmentioning

confidence: 99%

Propofol inhibits biological functions of leukaemia stem and differentiated cells through suppressing Wnt/β‐catenin and Akt/mTOR

Chen

Wan

Liu

et al. 2019

Clin Exp Pharma Physio

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Substantial evidence has shown that the anaesthetics and adjuvants given in the preoperative, intraoperative or postoperative period can affect cancer recurrence and overall survival in cancer patients. 1 A number of retrospective studies and clinical trials suggest that local anaesthesia alone or its addition to the general anaesthesia reduces cancer metastasis and recurrence, and improves overall survival. 2-4 In contrast, other anaesthetics, such as opioids, are immunosuppressive and decrease the patient's defenses against tumour progression. 5 The roles of anaesthetics have gained increased attention due to their potential long-term effects on cancer patients. Propofol is a short-acting intravenous anaesthetic reagent that is widely used for sedation and hypnosis during and after operation. 6 It has advantages over other anaesthetic drugs by protecting the immune system from being inhibited, and neuron cells from oxidative stress and hypoxia injury. 7,8 Compared to volatile agents, propofol has a lower inflammatory response. 9 A retrospective analysis compared propofol

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Section: Introductionmentioning

confidence: 99%

Propofol inhibits biological functions of leukaemia stem and differentiated cells through suppressing Wnt/β‐catenin and Akt/mTOR

Chen

Wan

Liu

et al. 2019

Clin Exp Pharma Physio

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show abstract

“…Propofol is a general sedative reagent and commonly used for induction and maintenance of general anesthesia [ 9 ]. It has advantages over other anesthetic drugs by protecting neuron and endothelial cells from oxidative stress and hypoxia injury [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Propofol enhances BCR-ABL TKIs’ inhibitory effects in chronic myeloid leukemia through Akt/mTOR suppression

Tan

Peng

et al. 2017

BMC Anesthesiol

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BackgroundThe anti-cancer activities of intravenous anesthetic drug propofol have been demonstrated in various types of cancers but not in chronic myeloid leukemia (CML).MethodsWe systematically examined the effect of propofol and its combination with BCR-ABL tyrosine kinase inhibitors (TKIs) in CML cell lines, patient progenitor cells and mouse xenograft model. We analyzed propofol’s underlying mechanism focusing on survival pathway in CML cells.ResultsWe show that propofol alone is active in inhibiting proliferation and inducing apoptosis in KBM-7, KU812 and K562 cells, and acts synergistically with imatinib or dasatinib, in in vitro cell culture system and in vivo xenograft model. In addition, propofol is more effective in inducing apoptosis and inhibiting colony formation in CML CD34 progenitor cells than normal bone marrow (NBM) counterparts. Combination of propofol and dasatinib significantly eliminates CML CD34 without affecting NBM CD34 cells. We further demonstrate that propofol suppresses phosphorylation of Akt, mTOR, S6 and 4EBP1 in K562. Overexpression of constitutively active Akt significantly reverses the inhibitory effects of propofol in K562, confirm that propofol acts on CML cells via inhibition of Akt/mTOR. Interestingly, the levels of p-Akt, p-mTOR and p-S6 are lower in cells treated with combination of propofol and imatinib than cells treated with propofol or imatinib alone, suggesting that propofol augments BCR-ABL TKI’s inhibitory effect via suppressing Akt/mTOR pathway.ConclusionOur work shows that propofol can be repurposed to for CML treatment. Our findings highlight the therapeutic value of Akt/mTOR in overcoming resistance to BCR-ABL TKI treatment in CML.Electronic supplementary materialThe online version of this article (10.1186/s12871-017-0423-2) contains supplementary material, which is available to authorized users.

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“…Obtaining OAEs under sedation was recommended, especially in severe ASD children, to control motor issues that may interfere with OAE testing (Tas et al, 2017). However, Gungor et al, 2016 observed a significant reduction in DPOAE levels with sedative agents.…”

Section: Discussionmentioning

confidence: 85%

Role of Otoacoustic Emissions in Hearing Assessment of Children with Autism

Elbabour

2023

mjsc

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Evaluation of hearing is essential in the diagnostic process of children suspected having autism spectrum disorder (ASD). The aim of this study was to examine the efficiency and feasibility of utilizing otoacoustic emissions as an objective test to assess hearing in children diagnosed with ASD. A pilot study was conducted over a period of 3 years (from September 2019 to November 2022) in the Audiology Department at the Center for Specialty Surgeries, Benghazi, Libya. A total of 61 children with autism aged between 2-15 years referred for hearing evaluation were enrolled in the study. The clinical procedure consisted of otoscopic ear examination, and Otoacoustic Emission (OAE) recording. OAE testing was attempted on the study sample (n 51) who met the inclusion criteria. And successfully completed for 44 participants (86%): 40 cases (91%) from the first attempt while 4 cases (9%) needed a second or more visit. Four autistic children (9%) had absent otoacoustic emissions in one ear. Testing couldn't be completed for 7 children (14%) due to behavioral difficulties. Results of this study showed the feasibility of using Distortion Product Otoacoustic Emissions (DPOAEs) in assessment of hearing for children with autism for whom obtaining reliable behavioral responses can be challenging.

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Comparison of anesthetic agents on otoacoustic emissions in children: propofol vs ketamine

Abstract: DPOAE measurements were reduced similarly by propofol and ketamine anesthesia. Lower false outcome ratio in TEOAE measurements made propofol a better option than ketamine.

Cited by 6 publications

References 14 publications

Propofol inhibits biological functions of leukaemia stem and differentiated cells through suppressing Wnt/β‐catenin and Akt/mTOR

Propofol inhibits biological functions of leukaemia stem and differentiated cells through suppressing Wnt/β‐catenin and Akt/mTOR

Propofol enhances BCR-ABL TKIs’ inhibitory effects in chronic myeloid leukemia through Akt/mTOR suppression

Role of Otoacoustic Emissions in Hearing Assessment of Children with Autism

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