Comparison of angiographic findings, risk factors, and long term follow-up between young and old patients with a history of myocardial infarction

Garoufalis, Stefanos; Kouvaras, George; Vitsias, George; Perdikouris, Kyriakos; Markatou, Paraskevi; Hatzisavas, Jhon; Kassinos, Neophytos; Karidis, K.; Foussas, Stefanos

doi:10.1016/s0167-5273(98)00194-6

Cited by 40 publications

(45 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1,3,[7][8][9]26,27) In the present study, the mortality rate was slightly lower in the young group. One of the reasons for the lower mortality in the young group was the lower rate of fatal complications, such as ventricular rupture.…”

Section: Discussionmentioning

confidence: 59%

“…The clinical features and outcomes of acute myocardial infarction (AMI) in the young are considered to be different from those in the non-young. [1][2][3][4][5][6][7][8][9] As diet patterns and lifestyles in the young are different from the non-young, 10,11) specific and unique considerations are needed for young AMI patients. It is important to elucidate the clinical features and outcomes of AMI in young patients.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Features of Myocardial Infarction in Young Japanese Patients

et al. 2013

View full text Add to dashboard Cite

SummaryClinical features and outcomes of acute myocardial infarction (AMI) in the young have been poorly investigated. The aim of this study was to investigate the clinical features and hospital outcomes of AMI in young Japanese. We conducted a case-control study. A total of 53 consecutive AMI patients whose age was ≤ 45 years old were assigned to the young group and 106 AMI patients whose age was > 45 years old were assigned to the non-young group. We compared the clinical features and hospital outcomes between the two groups. Compared with the non-young group, the young group was associated with male sex, hyperlipidemia, current smoking, being overweight, single vessel disease, and Killip class I on admission. There were no differences in the length of hospital stay or major adverse cardiac events between the groups. However, mortality and ventricular rupture were slightly lower in the young. In conclusion, young AMI patients had clinical characteristics different to those of the non-young patients. Compared to non-young patients, modifiable risk factors such as smoking, hyperlipidemia, and being overweight were associated with young AMI patients. (Int Heart J 2013; 54: 123-128) Key words: Angioplasty, Age, Ischemic heart disease A lthough the incidence of coronary artery disease in the young is still lower than that in the non-young, 1,2) coronary artery disease in the young has been increased recently. The clinical features and outcomes of acute myocardial infarction (AMI) in the young are considered to be different from those in the non-young. [1][2][3][4][5][6][7][8][9] As diet patterns and lifestyles in the young are different from the non-young, 10,11) specific and unique considerations are needed for young AMI patients. It is important to elucidate the clinical features and outcomes of AMI in young patients. We conducted a case-control study to elucidate the clinical features of AMI in young patients. MethodsCases and controls: We identified acute myocardial infarction patients from the hospital records of our medical center from January 2007 to March 2012. A diagnosis of AMI consisted of elevation of creatine kinase (at least 2-fold above the normal upper limit), and the presence of 1 of the following 2 criteria; (1) persistent chest pain or (2) ST-segment elevation or depression in the 12-lead electrocardiogram compatible with AMI. During the study period, 53 consecutive AMI patients whose age was ≤ 45 years old were assigned to the young group (Case group). 8,12) The control patients were selected from our AMI patients whose age was > 45 years old during the same study period. We designed the study so the ratio of cases to controls would be 1 to 2. To minimize the selection bias, consecutive AMI patients whose age was > 45 years old were assigned to the non-young group (Control group). In addition, to minimize any bias related to the therapeutic strategy for AMI, consecutive selection was conducted for each year. This study was approved by the institutional review board. PCI procedures: PCI was p...

show abstract

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Clinical Features of Myocardial Infarction in Young Japanese Patients

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Forty‐five years as the upper limit of defining young adults has been used in various studies and appears to be a reasonable boundary 1, 2, 3, 4, 5, 6, 7, 8, 9, 10. The same age definition has been, therefore, used in the current study on clinical characteristics and outcomes of ACS in young adults.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, there is a paucity of studies on ACS in the young adults defined as previously described,1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and the records of these analyses are often dated. The most known of these studies is based on the Get With the Guidelines‐Coronary Artery Disease registry data 1.…”

Section: Introductionmentioning

confidence: 99%

Acute Coronary Syndrome: The Risk to Young Women

Ricci

Cenko

Vasiljević

et al. 2017

JAHA

View full text Add to dashboard Cite

BackgroundAlthough acute coronary syndrome (ACS) mainly occurs in patients >50 years, younger patients can be affected as well. We used an age cutoff of 45 years to investigate clinical characteristics and outcomes of “young” patients with ACS.Methods and ResultsBetween October 2010 and April 2016, 14 931 patients with ACS were enrolled in the ISACS‐TC (International Survey of Acute Coronary Syndromes in Transitional Countries) registry. Of these patients, 1182 (8%) were aged ≤45 years (mean age, 40.3 years; 15.8% were women). The primary end point was 30‐day all‐cause mortality. Percentage diameter stenosis of ≤50% was defined as insignificant coronary disease. ST‐segment–elevation myocardial infarction was the most common clinical manifestation of ACS in the young cases (68% versus 59.6%). Young patients had a higher incidence of insignificant coronary artery disease (11.4% versus 10.1%) and lesser extent of significant disease (single vessel, 62.7% versus 46.6%). The incidence of 30‐day death was 1.3% versus 6.9% for the young and older patients, respectively. After correction for baseline and clinical differences, age ≤45 years was a predictor of survival in men (odds ratio, 0.24; 95% confidence interval, 0.10–0.58), but not in women (odds ratio, 1.35; 95% confidence interval, 0.50–3.62). This pattern of reversed risk among sexes held true after multivariable correction for in‐hospital medications and reperfusion therapy. Moreover, younger women had worse outcomes than men of a similar age (odds ratio, 6.03; 95% confidence interval, 2.07–17.53).Conclusion ACS at a young age is characterized by less severe coronary disease and high prevalence of ST‐segment–elevation myocardial infarction. Women have higher mortality than men. Young age is an independent predictor of lower 30‐day mortality in men, but not in women.Clinical Trial RegistrationURL: http://clinicaltrials.gov/. Unique identifier: NCT01218776.

show abstract

“…Patients a positive family history of premature coronary artery disease, and hypertension. [7][8][9][10][12][13][14][15] In our study, the most common risk factors over the years consistently included smoking, hypertension, and hypercholesterolemia. In earlier studies, smoking was reported in more than 90% of younger 16,17 and in 40% of older patients with AMI.…”

Section: Data Collectionmentioning

confidence: 99%