Comparison of Anti-Inflammatory Activity of Spirulina maxima Extract by Ultrasonication and Water Extraction Process

신재빈,; 최운용,; 강도형,; 이현용,

doi:10.3746/jkfn.2014.43.12.1852

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…Also, Sagara et al, (2015) express that antioxidant and free radical-scavenging properties of Spirulina platensis may be because of its phycocyanin content. Likewise, Sin et al (2014) and Ali et al (2015), establish that Spirulina inhibited expression of genes encoding TNF-α. The existing results revealed a significant (P≤0.05) upregulation of ACC, SREBT-1 and FAS gene expression in liver of NAFLD-induced in rats (G2) when compared with control group (G1).…”

Section: Discussionmentioning

confidence: 92%

The protective effects of Spirulina against Nonalcoholic fatty liver disease induced by high fat diet in rats

Hussein

Elsenosi

Khalid

et al. 2021

Benha Veterinary Medical Journal

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The ultimate goal of this study is to investigate the bimolecular changes in a rat model of high fat diet induced Non-alcoholic fatty liver disease (NAFLD). Also, the lipotropic, antioxidant and anti-inflammatory effects of spirulina platensis treatment were clarified through the evaluation of certain biochemical and molecular parameters in the blood and liver tissue of rats. Twenty one adult white albino rats were separated into three groups. Group I (Normal control): received no drugs and balanced diet, Group II (NAFLD-induced group): rats fed high fat diet for 8 weeks followed by normal basal ration feeding for another 8 weeks. Group III (NAFLD + spirulina): rats treated with spirulina orally at a dose of (150 mg/kg b.wt/day) for 8 weeks after induction of NAFLD. The obtained results showed a significant increase in serum total cholesterol (TC) and triacylglycerols (TAG) concentrations with significant up-regulation of liver gene expression TNF-α, IL-1β, NF-kβ, PPAR-α, ACC, FAS and SREBT-1in NAFLD-induced rats. Also, various histopathological alterations were detected in liver tissue of induced NAFLD rats. With spirulina treatment in NAFLD-induced rats, parameters measured near the normal level of rats group (G1). Also, spirulina potentially improved molecular hepatic function alterations related to NAFLD. Interestingly, histopathological findings supported that spirulina markedly attenuates harmful effects of NAFLD and protects liver tissue. We conclude that, spirulina has a great role as antioxidant, anti-obesity and anti-inflammatory via inhibition of liver lipid metabolic disturbance, steatosis and oxidative stress singling.

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Section: Discussionmentioning

confidence: 92%

The protective effects of Spirulina against Nonalcoholic fatty liver disease induced by high fat diet in rats

Hussein

Elsenosi

Khalid

et al. 2021

Benha Veterinary Medical Journal

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“…열수추출은 다양한 수용성 물질의 추출에 유리한 장점을 가지 고 있고, 추출용매의 잔류독성을 고려하지 않아도 되기 때문에 가장 많이 사용되는 방법이다. 하지만, 열수추출 방법은 비극 성 물질의 추출이 어렵고 (Kim et al, 2010), 실온에서는 추출효 율이 낮아 약 80~100°C의 열을 가해 추출하는데 이로 인하여 폴리페놀과 같은 유용물질의 파괴가 발생할 수 있는 단점을 지 니고 있다 (Shin et al, 2014). 또한, 장시간 추출 시에는 미생물 번식과 같은 안정성의 문제가 발생하기도 하고, 추출물의 장기 *Corresponding author: Sang-Hyun Lee Tel : +82-2-2049-6269 E-mail : sanghlee@konkuk.ac.kr 접수일(2021년 12월 21일)/수정일(2022년 1월 23일)/채택일(2022년 2월 10일) 보관시에는 유용물질의 변성이 유발될 수 있기 때문에 추출 이 후에는 동결건조와 같은 추가적인 공정이 필요하다 (Seo et al, 2015;Abbott, 2006;Pandey, 2014).…”

Section: 식물로부터의 유용물질을 추출하기 위해서 주로 사용하는unclassified

Storage Stability of Spirulina Extract Extracted with Natural Eutectic Solvent

Son¹,

Lee²

2022

J Korean Soc Cosmetol

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In this study, functional substances from Spirulina were extracted using deep eutectic solvent (DES) synthesized with cosmetic ingredients as a new natural extractant, In order to investigate the possibility of replacing water and ethanol, which are common extraction solvents, 9 kinds of DESs were synthesized. 3 DESs with low cytotoxicity were selected to extract functional substances from Spirulina. the contents of polyphenols, phycocyanin and ABTS radical scavenging ability of the Spirulina extract were measured to study the antioxidant activity. The polyphenol and phycocyanin contents of the Spirulina extract were highest when extracted with water. However, the antioxidant activity of the Spirulina extract prepared with sodium acetate: glycerol (SA: Gly) was 4 and 4.5-folds higher than those of the extract prepared with water and 70% ethanol, respectivly. The ability of DESs as preservatives for functional materials of Spirulina extract was also investigated. The polyphenols and phycocyanin of all DES extracts were more stably preserved than those in 70% ethanol or water. The antioxidant activity of Spirulina extract in sodium acetate:glycerol (1:3) was maintained over 60% after 9 days storage, while only 10% of initial activity was retained in 70% ethanol. These results show the potential of DESs as both extraction solvents and preservatives for functional substances from Spirulina.

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The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview

et al. 2016

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Spirulina is a species of filamentous cyanobacteria that has long been used as a food supplement. In particular, Spirulina platensis and Spirulina maxima are the most important. Thanks to a high protein and vitamin content, Spirulina is used as a nutraceutical food supplement, although its other potential health benefits have attracted much attention. Oxidative stress and dysfunctional immunity cause many diseases in humans, including atherosclerosis, cardiac hypertrophy, heart failure, and hypertension. Thus, the antioxidant, immunomodulatory, and anti-inflammatory activities of these microalgae may play an important role in human health. Here, we discuss the antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina in both animals and humans, along with the underlying mechanisms. In addition, its commercial and regulatory status in different countries is discussed as well. Spirulina activates cellular antioxidant enzymes, inhibits lipid peroxidation and DNA damage, scavenges free radicals, and increases the activity of superoxide dismutase and catalase. Notably, there appears to be a threshold level above which Spirulina will taper off the antioxidant activity. Clinical trials show that Spirulina prevents skeletal muscle damage under conditions of exercise-induced oxidative stress and can stimulate the production of antibodies and up- or downregulate the expression of cytokine-encoding genes to induce immunomodulatory and anti-inflammatory responses. The molecular mechanism(s) by which Spirulina induces these activities is unclear, but phycocyanin and β-carotene are important molecules. Moreover, Spirulina effectively regulates the ERK1/2, JNK, p38, and IκB pathways. This review provides new insight into the potential therapeutic applications of Spirulina and may provide new ideas for future studies.

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Comparison of Anti-Inflammatory Activity of Spirulina maxima Extract by Ultrasonication and Water Extraction Process

Cited by 6 publications

References 16 publications

The protective effects of Spirulina against Nonalcoholic fatty liver disease induced by high fat diet in rats

The protective effects of Spirulina against Nonalcoholic fatty liver disease induced by high fat diet in rats

Storage Stability of Spirulina Extract Extracted with Natural Eutectic Solvent

The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview

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