Comparison of antiallergic effects of pneumococcal conjugate vaccine and pneumococcal polysaccharide vaccine in a murine model of allergic rhinitis

Abstract

N/A.

Intranasal immunization with phosphorylcholine suppresses allergic rhinitis in mice

“…The present study demonstrated that intranasal pretreatment with PC suppresses nasal symptoms and allergic inflammation of the nasal mucosa in a murine model of AR. The inhibitory effects of intranasal immunization with PC on nasal symptoms are similar to those reported by previous studies, in which nasal symptoms in a murine AR model induced by sensitization with Der f were reduced by intranasal pretreatment with pneumococcal polysaccharide vaccine and pneumococcal conjugate vaccine . Furthermore, in the present study, the levels of serum IgE and eosinophil infiltration into the nasal mucosa were significantly decreased by intranasal PC pretreatment similar to the experiments using pneumococcal vaccines .…”

“…The same results were observed in the experiments using pneumococcal vaccines, although the administration of killed Spn before OVA sensitization significantly enhanced IFN‐γ production from mediastinal lymph node T cells . Furthermore, it has been reported that regulatory T cells are associated with the suppression of Th2‐type immune response by pneumococcal vaccines . Although PC is a T cell‐independent antigen and does not induce regulatory T cells, conjugation to a protein carrier such as KLH allows the involvement of T cells, indicating that intranasal administration of PC‐KLH might have induced regulatory T cells and suppressed IL‐4 production.…”

“…Some investigators have demonstrated the inhibition of allergic inflammation in animal models of asthma by intratracheal immunization with whole killed Spn or intranasal administration of pneumococcal conjugate vaccine . Kim et al and Shin et al reported that intranasal administration of pneumococcal conjugate vaccine and pneumococcal polysaccharide vaccine suppressed allergen‐specific IgE production and attenuated allergic inflammation in a murine model of allergic rhinitis (AR) sensitized with Dermatophagoides farinae (Der f) . Because PC is a component of pneumococcal cell wall and polysaccharide, its presence might be associated with the suppression of allergen‐specific IgE production and allergic inflammation in pneumococcal vaccine administration.…”

The anti-inflammatory effects of thymoquinone in a rat model of allergic rhinitis

“…Despite recent advances in understanding the mechanisms underlying allergic inflammation, current therapies can only alleviate the symptoms of disease. [4] Since these therapies are still imperfect, it is important to continue to study the pharmacology of this disease as part of the search to obtain better drugs.…”

Inhibitory Effect of Pycnogenol® on Airway Inflammation in Ovalbumin-Induced Allergic Rhinitis

“…Many important pharmacological agents have been used to treat AR (6). Pycnogenol ® (PYC) is a natural plant extract achieved from the French maritime pine Pinus pinaster bark (Pinus maritime) (7,8).…”