Comparison of antibacterial activity and cytotoxicity of silver nanoparticles and silver-loaded montmorillonite and saponite

Gil-Korilis, Adrián; Cojocaru, Mihail; Berzosa, Melibea; Gamazo, Carlos; Andrade, Natália J.; Ciuffi, Kátia J.

doi:10.1016/j.clay.2023.106968

Cited by 13 publications

(4 citation statements)

References 255 publications

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“…Dose-dependent toxicity was noted, with higher doses correlating to increased toxicity. The nanoparticle's form also played a role, with spherical nanoparticles showing heightened toxicity compared to other forms ( 48 ). The precipitation of silver, and its association with protein complexes, favors its penetration ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity and concentration of silver ions released from dressings in the treatment of infected wounds: a systematic review

Sánchez-Gálvez,

Martínez-Isasi,

Gómez-Salgado

et al. 2024

Front. Public Health

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IntroductionSilver-releasing dressings are used in the treatment of infected wounds. Despite their widespread use, neither the amount of silver released nor the potential in vivo toxicity is known. The aim of this study was to evaluate the cytotoxic effects and the amount of silver released from commercially available dressings with infected wounds.MethodsThe review was conducted according to the PRISMA statement. The Web of Science, PubMed, Embase, Scopus, and CINAHL databases were searched for studies from 2002 through December 2022. The criteria were as follows: population (human patients with infected wounds); intervention (commercial dressings with clinical silver authorized for use in humans); and outcomes (concentrations of silver ions released into tissues and plasma). Any study based on silver-free dressings, experimental dressings, or dressings not for clinical use in humans should be excluded. According to the type of study, systematic reviews, experimental, quasi-experimental, and observational studies in English, Spanish, or Portuguese were considered. The quality of the selected studies was assessed using the JBI critical appraisal tools. Studies that assessed at least 65% of the included items were included. Data were extracted independently by two reviewers.Results740 articles were found and five were finally selected (all of them quasi-experimental). Heterogeneity was found in terms of study design, application of silver dressings, and methods of assessment, which limited the comparability between studies.ConclusionIn vivo comparative studies of clinical dressings for control of infection lack a standardized methodology that allows observation of all the variables of silver performance at local and systemic levels, as well as evaluation of its cytotoxicity. It cannot be concluded whether the assessed concentrations of released silver in commercial dressings for the topical treatment of infected wounds are cytotoxic to skin cells.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022351041, PROSPERO [CRD42022351041].

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Section: Discussionmentioning

confidence: 99%

Cytotoxicity and concentration of silver ions released from dressings in the treatment of infected wounds: a systematic review

Sánchez-Gálvez,

Martínez-Isasi,

Gómez-Salgado

et al. 2024

Front. Public Health

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“…Linima VK et al [19] report highly promising antimicrobial, antiviral, and anticancer properties from using AgNPs, including antibacterial and antifungal activity against Salmonella typhi, Staphylococcus aureus, and the fungus Aspergillus flavus. According to laboratory testing, the bactericidal activity against Staphylococcus aureus and Escherichia coli presented by the AgNPs could be related to a high concentration of the nanoparticles; however, very high concentrations could cause toxicity [20,21]. Other microorganisms, such as Pseudomonas stutzeri, have shown resistance and accumulation against AgNPs [22].…”

Section: Properties Of Agnps Against Microorganisms and Fungimentioning

confidence: 99%

Optimization of the Antifungal Property in a Composite of Polyurethane and Silver Nanoparticles against the Trichophyton rubrum Fungus

Mares Castro,

Estrada Monje,

Saldívar Campos

et al. 2023

Applied Sciences

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This research aims to analyze and optimize the antifungal property of a composite material made of polyurethane (PUR) and silver nanoparticles (AgNPs) against the fungus Trichophyton rubrum to find the optimal parameters that allow the highest inhibition of the fungal growth to be used in healthcare aimed at the population vulnerable to fungal infections, such as people suffering from diabetes mellitus, thus creating an opportunity for the generation of antifungal products for healthcare applications. This study analyzes the effect of three variables on the antifungal properties of the composite material: nanoparticle size, concentration, and the application of an ultrasonic treatment as a method to aid the dispersion of the AgNPs into PUR matrix. The proposed methodology includes tests in accordance with a standar to evaluate the growth inhibition of the fungi on a culture medium. A categorical logistic regression model was adjusted from 23 factorial design with five replicates, which was optimized by the use of multi-objective genetic algorithms. The experimental factors showed a significant effect on the growth inhibition of the fungus, and the optimal levels were determined.

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“…Refined MMT has been studied for various common health applications, such as cosmetics [ 7 , 8 ], wound dressings [ 9 , 10 , 11 , 12 , 13 ], and anti-diarrhea medicines [ 14 ], owing to the uniform bidimensional particle shapes, high length-to-height ratios, inherent stiffness, dual charge distribution, chemical inertness, biocompatibility, and active sites on the surface [ 15 , 16 , 17 , 18 ]. The results of these studies have attracted the interest of scientists and biotechnologists since micro/nanosized materials might also exhibit the same micro/nano biological interactions because one functional dimension is outside the nanoscale range of 1 nm to 100 nm, whereas organ-modified micro/nanosized materials might have uncertain effects on micro/nanobiological interactions [ 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Toxicological Evaluation toward Refined Montmorillonite with Human Colon Associated Cells and Human Skin Associated Cells

Wang,

Jiang,

Tian

et al. 2024

JFB

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Montmorillonite has been refined to overcome uncertainties originating from different sources, which offers opportunities for addressing various health issues, e.g., cosmetics, wound dressings, and antidiarrheal medicines. Herein, three commercial montmorillonite samples were obtained from different sources and labeled M1, M2, and M3 for Ca-montmorillonite, magnesium-enriched Ca-montmorillonite, and silicon-enriched Na-montmorillonite, respectively. Commercial montmorillonite was refined via ultrasonic scission-differential centrifugation and labeled S, M, or L according to the particle sizes (small, medium, or large, respectively). The size distribution decreased from 2000 nm to 250 nm with increasing centrifugation rates from 3000 rpm to 12,000 rpm. Toxicological evaluations with human colon-associated cells and human skin-associated cells indicated that side effects were correlated with excess dosages and silica sand. These side effects were more obvious with human colon-associated cells. The microscopic interactions between micro/nanosized montmorillonite and human colon-associated cells or human skin-associated cells indicated that those interactions were correlated with the size distributions. The interactions of the M1 series with the human cells were attributed to size effects because montmorillonite with a broad size distribution was stored in the M1 series. The M2 series interactions with human cells did not seem to be correlated with size effects because large montmorillonite particles were retained after refining. The M3 series interactions with human cells were attributed to size effects because small montmorillonite particles were retained after refining. This illustrates that toxicological evaluations with refined montmorillonite must be performed in accordance with clinical medical practices.

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Comparison of antibacterial activity and cytotoxicity of silver nanoparticles and silver-loaded montmorillonite and saponite

Cited by 13 publications

References 255 publications

Cytotoxicity and concentration of silver ions released from dressings in the treatment of infected wounds: a systematic review

Cytotoxicity and concentration of silver ions released from dressings in the treatment of infected wounds: a systematic review

Optimization of the Antifungal Property in a Composite of Polyurethane and Silver Nanoparticles against the Trichophyton rubrum Fungus

Toxicological Evaluation toward Refined Montmorillonite with Human Colon Associated Cells and Human Skin Associated Cells

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