Comparison of antibiotic-resistant bacteria and antibiotic resistance genes abundance in hospital and community wastewater: A systematic review

Hassoun-Kheir, Nasreen; Stabholz, Yoav; Kreft, Jan‐Ulrich; Cruz, Roberto de la; Romalde, Jesús L.; Nesme, Joseph; Sørensen, Søren J.; Smets, Barth F.; Graham, David W.; Paul, Mical

doi:10.1016/j.scitotenv.2020.140804

Cited by 169 publications

(71 citation statements)

References 56 publications

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“…We believe that the increase in the number of infections in direct-admitted patients resulted from the increased number of eHRB in the community in patients without previous contact with the health care system. Even if carbapenemase-producing Enterobacteriaceae were usually associated with hospital dissemination [33], it has been recently reported that strains-producing carbapenemases dissemination occurs outside the hospital [34], and that CRE/CPE and VRE were frequently identified in hospital and community wastewater [35], which may reflect the dissemination of these strains, in particular VREs, in the community. To our knowledge, our study is the first one to evaluate the community-onset of clinically significant infections in different care settings and their trends over an extended observation period, which allows us to demonstrate an increased frequency of community-onset infections, some of them diagnosed during a hospital stay.…”

Section: Discussionmentioning

confidence: 99%

Trends in community- and nosocomial-acquired infections of carbapenem resistant Enterobacteriaceae (CRE), carbapenemase producing Enterobacteriaceae (CPE) and vancomycin resistant Enterococcus (VRE): a 10-year prospective observational study

Arriola

Banchon

Gabriel

et al. 2021

Preprint

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Introduction: CRE, CPE, and VRE are considered significant threats to public health. Aim : To determine trends of nosocomial- and community-acquired infections. Methods: A 10-year prospective observational non-interventional study was conducted. We used time-series analysis to evaluate trends in infections number. Findings : Infection rate (%) were: CRE 2.48 (261/10,533), CPE 1.66 (175/10,533) and VRE 15.9 (121/761). We found diminishing trends for CRE (-19% [-31;-5], P=.03) and CPE (-22% [-30;-8], P=.04) but increasing trend for VRE (+48; [CI95% 34;75], P=.001). While we found decreasing trends for CRE and CPE in emergency (-71 [-122;-25], P=.001; -45 [-92;-27], P=.001) and hospitalization (-127 [-159;-85], P=.001; -56 [-98;-216], P=.01), we found increasing trends for VRE (+148 [113;192], P=.00001; +108 [65;152], P=.003). Nosocomial-infections fell in CRE (-238 [-183;-316], P=.0001) and CPE (-163 [-96;-208], P=.001), but rose in VRE (+196 [151;242], P=.0001). We showed increasing trends in ambulatory and community-acquired infections in CRE (+134% [96;189]; P=.001; +77% [52;89]; P= .002), CPE (+288 [226;343]; P=.0001; +21% [-12;46]; P=.0.08) and VRE (+348 [295;458]; P=.0001; +66% [41;83]; P=.003). Direct admitted trends rose in all groups (CRE 16% [-8; 42]; P=.05), CPE 23% [-6; 48] (P=.05) and VRE (+241 [188; 301]; P=.0001). Conclusions : We found a changing infection pattern with decreasing trends in in-hospital settings and nosocomial-acquired infections but increasing ambulatory and community-acquired infections. The observed increasing-trends in direct-admitted could be explained by community-onset infections diagnosed in the hospital. Our findings highlight the need to identify CRE/CPE/VRE community-acquired infections in ambulatory and in-hospital settings.

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Section: Discussionmentioning

confidence: 99%

Trends in community- and nosocomial-acquired infections of carbapenem resistant Enterobacteriaceae (CRE), carbapenemase producing Enterobacteriaceae (CPE) and vancomycin resistant Enterococcus (VRE): a 10-year prospective observational study

Arriola

Banchon

Gabriel

et al. 2021

Preprint

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“…The decreasing antibiotic efficiency gives the space for the development of bacterial infections and contamination that are a lot less treatable as they used to be. It emerged because of the over-and misuse of antibiotics in human healthcare [6][7][8][9] and the lack of proper removal from hospital wastewaters [10], as well as livestock since their antibacterial properties are combined with a growth factor promotion effect [11]. It was a strategy to use them as preventive in the food industry to increase the quantity of meat and dairy products to feed the always growing and demanding population while keeping safe-to-consumption products [12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Properties, mechanism and applications of diamond as an antibacterial material

et al. 2021

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antibiotic resistance in bacteria is a current threat causing an increasing number of infections of difficult clinical management. While the overuse and misuse of antibiotics are investigated to reduce them, the need for alternatives to approaches is rising. carbon-based materials shown recent moderate to high antibacterial properties and diamond, thanks to its superior mechanical, tribological, electrical, chemical and biological quality is a choice material to investigate for safe antibacterial films, coatings and particles. here, the antibacterial properties of diamond films, nanodiamonds, Dlc films and a comprehensive list of the composites developed from them are discussed along with a summary of the bacterial strains used and the most efficient composition and/or concentration discovered. in a later stage, the mechanisms of action and the parameters that are believed to influence them are discussed and finally, an overview of the biomedical and food industry applications is given.

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“…Several studies have reported that these antibiotics and their residues pose a substantial toxic risk to aquatic organisms [1]. Moreover, antibiotic residues can accelerate the production of antibiotic-resistant bacteria and antibiotic-resistant genes even at low concentrations, which could be a major threat to public health globally [2,3]. Extensive studies have reported that antibiotic compounds originating from HWW can be transported to ponds, rivers, and wastewater treatment plants [4].…”

Section: Introductionmentioning

confidence: 99%

Removal of Antibiotics from Real Hospital Wastewater by Cold Plasma Technique

Nguyen

Tran

et al. 2021

Journal of Chemistry

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Hospital wastewater contains a complex mixture of bioactive substances and microorganisms that are deleterious to humans and aquatic animals. In this study, four antibiotics, namely, ofloxacin, ciprofloxacin, cefuroxime, and amoxicillin, respectively, from the wastewater of seven hospitals in Ho Chi Minh City, Vietnam, were monitored. The results revealed that the wastewater from these hospitals is contaminated with at least one of the antibiotics. In addition, the degradation capacity of the antibiotics by the wastewater treatment plant at one of the hospitals by the cold plasma technique was investigated. Furthermore, effects of the variation in pH, interelectrode distance, applied voltage, and reaction time on the removal efficiency were investigated in terms of the reduction in antibiotics concentration, COD, and ammonia. Ciprofloxacin, cefuroxime, COD, and ammonia were almost eliminated, while ofloxacin and amoxicillin were reduced by more than 72% under optimum conditions (initial pH of 10, reaction time of 15 min, applied voltage of 30 kV, and interelectrode distance of 10 mm). All of these factors affected the removal efficiency. The removal efficiency was most robust in the first 5 min, and it increased with the increase in the reaction time. However, the removal efficiency tended to saturate over time, while it decreased with the increase in the reaction time. With an applied voltage of 30 kV onwards, the removal efficiency was not significantly different. Most of the pollutants were predominately eliminated under slightly alkaline conditions (pH of ∼10). In addition, primary oxidants in the aqueous phase, such as O3, H2O2, and ⋅OH, were generated. Besides, the obtained results also revealed that the decomposition of ciprofloxacin and cefuroxime follows the first-order reaction kinetics; meanwhile, the third-order reaction kinetics was most likely for the decomposition of ofloxacin and amoxicillin.

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Comparison of antibiotic-resistant bacteria and antibiotic resistance genes abundance in hospital and community wastewater: A systematic review

Cited by 169 publications

References 56 publications

Trends in community- and nosocomial-acquired infections of carbapenem resistant Enterobacteriaceae (CRE), carbapenemase producing Enterobacteriaceae (CPE) and vancomycin resistant Enterococcus (VRE): a 10-year prospective observational study

Trends in community- and nosocomial-acquired infections of carbapenem resistant Enterobacteriaceae (CRE), carbapenemase producing Enterobacteriaceae (CPE) and vancomycin resistant Enterococcus (VRE): a 10-year prospective observational study

Properties, mechanism and applications of diamond as an antibacterial material

Removal of Antibiotics from Real Hospital Wastewater by Cold Plasma Technique

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