Comparison of antifungal and cytotoxicity activities of titanium dioxide and zinc oxide nanoparticles with amphotericin B against different <i>Candida</i> species: In vitro evaluation

Kermani, S.; Salari, Samira; Almani, Pooya Ghasemi Nejad

doi:10.1002/jcla.23577

Cited by 43 publications

(19 citation statements)

References 22 publications

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“…The antifungal effect of TiO2NPs against C. albicnas was obvious in the modified groups when compared to control group, this finding agrees with results of a study 39 who found that up to 65% of the C. albicans were killed after exposure to 100 μg/mL of TiO2NPs. A similar results was concluded with of Kermani et al 40 who found that higher percentage of the titanium and zinc oxide nanoparticles increased their toxicity. It was documented that TiO2NPs cause C. albicans yeast cell death by producing intracellular reactive oxygen species (ROS), this in turn causes oxidation of the Coenzyme-A and peroxidation of lipids which subsequently decreases respiratory activity and ultimately causes cell death 41 .…”

Section: Discussionsupporting

confidence: 89%

Effect of adding titanium dioxide nanoparticles on anti-microbial activity and surface detail reproduction of dental alginate

et al. 2023

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Most dental works require a diagnostic impression; alginate is contemplated as the most popular material used for this purpose. Titanium dioxide nanoparticles show evidence of antimicrobial activity in the recent era, for this purpose, this study aimed to evaluate the effect of adding Titanium dioxide nanoparticles on antimicrobial activity and surface detail reproduction of alginate impression material. Materials and methods: Titanium dioxide nanoparticles (purity = 99%, size= 20nm) was added to alginate at three different concentrations (2%, 3% and 5%). 84 samples were prepared in total. Samples were tested for antimicrobial activity using a disc diffusion test, and surface detail reproduction was done using (ISO 21563:2021). One-way ANOVA and independent sample t-test were used for data analysis through SPSS software. Results: for the antimicrobial test, inhibition zones for Streptococcus mutans and Candida albicans showed significant changes concerning the alteration in Titanium dioxide nanoparticle concentrations. The inhibition zone significantly increased with an increase in the percentage of Titanium dioxide nanoparticles. The mean of the inhibition zone for S. mutans was superior to C. albicans and the difference was statistically significant. Regarding surface detail reproduction, the control group, 2% and 3% groups manifested very similar results, only the group to which 5% of Titanium dioxide nanoparticles were added showed a decline in detail reproduction when compared to the other three groups. Conclusion: Within the limitation of this study, we can conclude that the antimicrobial activity against S mutans and C. albicans were significantly increased in modified groups, and this escalation was directly linked to the increase in Titanium dioxide nanoparticles concentration. In contrast, the surface detail reproduction was decreased when adding 5% Titanium dioxide nanoparticles to alginate.

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Section: Discussionsupporting

confidence: 89%

Effect of adding titanium dioxide nanoparticles on anti-microbial activity and surface detail reproduction of dental alginate

et al. 2023

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“…This demonstrates the effectiveness of ZnO nanoparticles and the tolerance of eukaryotic cells to these nanoparticles. Another In Vitro study in Iran showed that using ZnO NP against C. albicans resulted in a minimum inhibitory concentration of 128 μg/mL and a minimum fungicidal concentration of 256 μg/mL [ 59 ]. In contrast our study, using ZnO NPs at 99.18 μg/mL + 1-min UV-B had 100 % growth inhibition.…”

Section: Discussionmentioning

confidence: 99%

Enhanced antimicrobial efficacy of biogenic ZnO nanoparticles through UV-B activation: A novel approach for textile garment

Asmat-Campos,

Rojas-Jaimes,

Simbrón de la Cruz

et al. 2024

Heliyon

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“…CuO NPs have a major effect on fungi destructuration, while the polymer creates a biocompatible platform that sustains contact with the oral mucosa and the release of NPs [ 175 ]. Similarly, TiO 2 and ZnO NPs were studied for their antifungal activity as potential alternatives to amphotericin, but their effect was favorable at higher MIC values than the antifungal MIC [ 176 ].…”

Section: Biomaterials and Nanotechnological Approachesmentioning

confidence: 99%

Molecular Mapping of Antifungal Mechanisms Accessing Biomaterials and New Agents to Target Oral Candidiasis

Anuța

Talianu

Dinu-Pîrvu

et al. 2022

IJMS

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Oral candidiasis has a high rate of development, especially in immunocompromised patients. Immunosuppressive and cytotoxic therapies in hospitalized HIV and cancer patients are known to induce the poor management of adverse reactions, where local and systemic candidiasis become highly resistant to conventional antifungal therapy. The development of oral candidiasis is triggered by several mechanisms that determine oral epithelium imbalances, resulting in poor local defense and a delayed immune system response. As a result, pathogenic fungi colonies disseminate and form resistant biofilms, promoting serious challenges in initiating a proper therapeutic protocol. Hence, this study of the literature aimed to discuss possibilities and new trends through antifungal therapy for buccal drug administration. A large number of studies explored the antifungal activity of new agents or synergic components that may enhance the effect of classic drugs. It was of significant interest to find connections between smart biomaterials and their activity, to find molecular responses and mechanisms that can conquer the multidrug resistance of fungi strains, and to transpose them into a molecular map. Overall, attention is focused on the nanocolloids domain, nanoparticles, nanocomposite synthesis, and the design of polymeric platforms to satisfy sustained antifungal activity and high biocompatibility with the oral mucosa.

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Comparison of antifungal and cytotoxicity activities of titanium dioxide and zinc oxide nanoparticles with amphotericin B against different Candida species: In vitro evaluation

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 43 publications

References 22 publications

Effect of adding titanium dioxide nanoparticles on anti-microbial activity and surface detail reproduction of dental alginate

Effect of adding titanium dioxide nanoparticles on anti-microbial activity and surface detail reproduction of dental alginate

Enhanced antimicrobial efficacy of biogenic ZnO nanoparticles through UV-B activation: A novel approach for textile garment

Molecular Mapping of Antifungal Mechanisms Accessing Biomaterials and New Agents to Target Oral Candidiasis

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