Comparison of AUA and phoenix definitions of biochemical failure following permanent brachytherapy for prostate cancer

Direct Comparison of Two Different Definitions with Biochemical Recurrence after Low-Dose-Rate Brachytherapy for Prostate Cancer

“…For PCa with any risk, increasing the BED to ≥200 Gy was not associated with an improvement in the 5-year BCR [ 24 ]. Regarding the slope coefficient of the meta-regression, each 10-Gy increase in the BED did not significantly ( p > 0.05) improve BRFS, by almost zero units, which is consistent with a plateau in the dose–response sigmoid curve [ 25 ]. Previous reports have indicated LDR-BT as an effective treatment for PCa, although its therapeutic effect remains almost the same after exceeding the prescribed dose.…”

“…As with RP, the high threshold of the Phoenix definition has also been questioned with LDR-BT for the prostate, since LDR-BT often results in the complete ablation of glandular tissue and PSA values remain undetectable [ 13 , 22 , 23 ]. Moreover, the Phoenix definition may significantly underestimate the BCR at a follow-up of up to 15 years, and there is the antinomy with respect to sensitivity and specificity for defining the BCR [ 25 ]. Based on a report from Mount Sinai Hospital, which included 2634 patients with clinical T1-T4N0M0 PCa, 293 (11.1%) met the Phoenix definition of BCR and 457 (17.5%) met the RP definition ( p < 0.001) [ 25 ].…”

“…Moreover, the Phoenix definition may significantly underestimate the BCR at a follow-up of up to 15 years, and there is the antinomy with respect to sensitivity and specificity for defining the BCR [ 25 ]. Based on a report from Mount Sinai Hospital, which included 2634 patients with clinical T1-T4N0M0 PCa, 293 (11.1%) met the Phoenix definition of BCR and 457 (17.5%) met the RP definition ( p < 0.001) [ 25 ]. BRFS according to the Phoenix definition was superior to that according to the RP definition at 5 and 10 years, but not at 15 years [ 25 ].…”

“…Based on a report from Mount Sinai Hospital, which included 2634 patients with clinical T1-T4N0M0 PCa, 293 (11.1%) met the Phoenix definition of BCR and 457 (17.5%) met the RP definition ( p < 0.001) [ 25 ]. BRFS according to the Phoenix definition was superior to that according to the RP definition at 5 and 10 years, but not at 15 years [ 25 ]. For patients with PCa who did or did not receive ADT, the BCR rate was lower when using the Phoenix definition than when using the RP definition, which was 6.0% vs. 10.0% ( p < 0.001) and 9.3% vs. 12.4% ( p < 0.001), respectively [ 25 ].…”

“…BRFS according to the Phoenix definition was superior to that according to the RP definition at 5 and 10 years, but not at 15 years [ 25 ]. For patients with PCa who did or did not receive ADT, the BCR rate was lower when using the Phoenix definition than when using the RP definition, which was 6.0% vs. 10.0% ( p < 0.001) and 9.3% vs. 12.4% ( p < 0.001), respectively [ 25 ]. In the multivariate analysis, BCR was statistically correlated with the initial PSA, clinical T stage, GG, and BED for both the Phoenix and RP definitions [ 25 ].…”