Comparison of behavioral and psychological symptoms in early‐onset and late‐onset Alzheimer's disease

Toyota, Yasutaka; Ikeda, Manabu; Shinagawa, Shunichiro; Matsumoto, Teruhisa; Matsumoto, Naomi; Hokoishi, Kazuhiko; Fukuhara, Ryuji; Ishikawa, Tomohisa; Mori, Takaaki; Adachi, Hiroyoshi; Komori, Kenjiro; Tanabe, Hirotaka

doi:10.1002/gps.1760

Cited by 77 publications

(83 citation statements)

References 35 publications

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“…Results from studies assessing the prevalence rates of NPS in outpatient samples applying the NPI are summarized in table 2 (9,(17)(18)(19)(20)(21)(22)(23)(24)(25). Four studies (9,17,23,24) presented the proportion of patients who experienced at least one NPI symptom (> 0), which ranged from 88% to 98%.…”

Section: Nps In Persons With Dementia Attending Outpatient Clinicsmentioning

confidence: 99%

“…The study of Aalten et al, in which one of the inclusion criteria was having at least one clinically significant (> 3) NPI symptom, pooled several datasets, and some of the participants in other studies noted in the table may have been included in this study (18). Toyota et al compared patients with early-onset dementia to patients with late-onset dementia and found that delusions, hallucinations, agitation/aggression, disinhibition, and aberrant motor behavior were more common in lateonset dementia (19). Longitudinal studies indicate that virtually all persons with dementia experienced NPS during the follow-up.…”

Section: Nps In Persons With Dementia Attending Outpatient Clinicsmentioning

confidence: 99%

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The prevalence and the course of neuropsychiatric symptoms in patients with dementia

Bergh¹,

Selbæk²

2012

Nor J Epidemiol

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Dementia is prevalent in Norway and other countries and is hallmarked by a decline in memory and other cognitive abilities. In addition to cognitive decline, the vast majority of patients with dementia experience neuropsychiatric symptoms (NPS) such as depression, agitation, psychosis, apathy, or irritability. In this review, we describe the prevalence and the course of NPS in patients with dementia, referring to results of population-based studies, studies of outpatients, and studies of patients in long-term care. For a better comparison of the included studies and for clarification, we have included studies that have assessed NPS with the Neuropsychiatric Inventory (NPI). Overall, we found a high prevalence rate of NPS. At least one NPS (NPI > 0) was present in 56% to 98% of the patients and 62% to 84% of the patients had at least one clinically significant NPS (NPI > 3). The NPS with the highest prevalence rate were apathy, irritability, agitation, depression and anxiety; while delusion, hallucination, disinhibition, aberrant motor behavior and euphoria were the least frequent NPS.

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Section: Nps In Persons With Dementia Attending Outpatient Clinicsmentioning

confidence: 99%

Section: Nps In Persons With Dementia Attending Outpatient Clinicsmentioning

confidence: 99%

The prevalence and the course of neuropsychiatric symptoms in patients with dementia

Bergh¹,

Selbæk²

2012

Nor J Epidemiol

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“…For instance, Toyota et al (2007) compared NPS between community-dwelling people with YO-AD and LO-AD and did not find differences regarding the prevalence of depressive symptoms and anxiety. Moreover, they found fewer delusions and hallucinations as well as less agitation, disinhibition, and aberrant motor behavior in YO-AD than in LO-AD.…”

Section: Introductionmentioning

confidence: 97%

Differences in neuropsychiatric symptoms between nursing home residents with young-onset dementia and late-onset dementia

Appelhof

Bakker

IJssel

et al. 2018

Aging & Mental Health

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Objective: The aims of the current study are (1) to explore the differences in neuropsychiatric symptoms (NPS) between young-onset dementia (YOD) and late-onset dementia (LOD), and (2) to investigate whether the possible differences can be attributed to differences in dementia subtype, gender, psychotropic drug use (PDU), or dementia severity. Method: Three hundred and eighty-six nursing home (NH) residents with YOD and 350 with LOD were included. Multilevel modeling was used to compare NPS between the groups . Furthermore, dementia subtype, gender, PDU, and dementia severity were added to the crude multilevel models to investigate whether the possible differences in NPS could be attributed to these characteristics. Results: Higher levels of apathy were found in NH residents with YOD. After the characteristics were added to the models, also lower levels of verbally agitated behaviors were found in YOD . Conclusion: We recommend that special attention be paid to interventions targeting apathy in YOD. Although no differences in other NPS were found, the PDU rates were higher in YOD, suggesting that the threshold for the use of PDU in the management of NPS is lower. This underscores the need for appropriate attention to non-pharmacological interventions for the management of NPS in YOD.

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“…Several studies did not find any distinctive differences between EOAD and LOAD patients (Cummings et al, 1985;Bayles et al, 1987;Grady et al, 1987;Selnes et al, 1988;Toyota et al, 2007) or have attributed such differences to dementia severity (Jacobs et al, 1994;Smits et al, 2012). Regarding memory, a relative sparing of memory in EOAD has been reported (Binetti et al, 1996;Smits et al, 2012), while several studies have found that LOAD patients present primarily with memory difficulties (Jacobs et al, 1994;Imamura et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Early-onset and late-onset Alzheimer's disease are associated with distinct patterns of memory impairment

Joubert

Gour

Guedj

et al. 2016

Cortex

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The goal of this study was to investigate the specific patterns of memory breakdown in patients suffering from early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD). Twenty EOAD patients, twenty LOAD patients, twenty matched younger controls, and twenty matched older controls participated in this study.All participants underwent a detailed neuropsychological assessment, an MRI scan, an FDG-PET scan, and AD patients had biomarkers as supporting evidence of both amyloïdopathy and neuronal injury. Results of the neuropsychological assessment showed that both EOAD and LOAD groups were impaired in the domains of memory, executive functions, language, praxis, and visuoconstructional abilities, when compared to their respective control groups. EOAD and LOAD groups, however, showed distinct patterns of memory impairment. Even though both groups were similarly affected on measures of episodic, short term and working memory, in contrast semantic memory was significantly more impaired in LOAD than in EOAD patients. The EOAD group was not more affected than the LOAD group in any memory domain. EOAD patients, however, showed significantly poorer performance in other cognitive domains including executive functions and visuoconstructional abilities. A more detailed analysis of the pattern of semantic memory performance among patient groups revealed that the LOAD was more profoundly impaired, in tasks of both spontaneous recall and semantic recognition.Voxel-Based Morphometry (VBM) analyses showed that impaired semantic performance in patients was associated with reduced gray matter volume in the anterior temporal lobe region, while PET-FDG analyses revealed that poorer semantic performance was associated with greater hypometabolism in the left temporoparietal region, both areas reflecting key regions of the semantic network. Results of this study indicate that EOAD and LOAD patients present with distinct patterns of memory impairment, and that a genuine semantic impairment may represent one of the clinical hallmarks of LOAD.

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Comparison of behavioral and psychological symptoms in early‐onset and late‐onset Alzheimer's disease

Abstract: In EO-AD, behavioral and psychological symptoms are relatively fewer than LO-AD at the first medical assessment.

Cited by 77 publications

References 35 publications

The prevalence and the course of neuropsychiatric symptoms in patients with dementia

The prevalence and the course of neuropsychiatric symptoms in patients with dementia

Differences in neuropsychiatric symptoms between nursing home residents with young-onset dementia and late-onset dementia

Early-onset and late-onset Alzheimer's disease are associated with distinct patterns of memory impairment

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