Comparison of benign lesion regression following vocal fold steroid injection and vocal hygiene education

Abstract

4.

Long-term Surveillance Following Intralesional Steroid Injection for Benign Vocal Fold Lesions

“…Therefore, our group conducted a comparative study and found a significantly higher lesion regression rate in VFSI compared with that after only vocal hygiene education. 30 Potential adverse effects of VFSI have also been reported in a recent series, in which the incidence rates for vocal fold hematoma, deposition of triamcinolone, and vocal fold atrophy were 20%, 4%, and 1%, respectively. 33 Considering that most benign vocal lesions result from phonotrauma, it has been proposed that VFSI might take effect via decreasing cellular permeability, 34 down-regulation of proinflammatory cytokines, 35 decreasing rates and amounts of collagen deposition during the healing process, 36 and reducing fibroblast proliferation and transforming growth factor β (TGF-β)-induced collagen synthesis.…”

Comprehensive Outcome Researches of Intralesional Steroid Injection on Benign Vocal Fold Lesions

“…[11][12][13] The clinical effectiveness of VFSI was further documented in our recent study that demonstrated significantly higher lesion reduction rates after VFSI than following vocal hygiene education. 22 This study investigated the multidimensional treatment outcomes among the most common vocal fold pathologies. For vocal nodules, we demonstrated that VFSI can result in significant subjective and objective improvements ( Table 1, left column), which was comparable with previously published results.…”

“…17,48 Another potential risk factor for post-VFSI vocal hematoma is high occupational vocal demand (Table 4). Although this study did not investigate the compliance rate of voice rest after VFSI, we presumably suspected that patients with high occupational vocal demands might be less able to maintain 3 days of voice rest after VFSI than were patients with routine vocal demands, 22 which might result in oozing before the injection wound was completely healed. A previous study observed a 5% incidence rate of vocal fold atrophy after VFSI.…”

“…Under visual guidance, 0.1 mL, 1:1 mixture of triamcinolone acetonide (10 mg/mL) and dexamethasone sodium phosphate (5 mg/mL) was injected by curved injection needle (Model 16-50050, Medtronic Xomed Jacksonville, Florida, USA) into the Reinke's space of the vocal lesions. 22 For patients who were intolerant of the above transoral procedure, 23 transnasal injection via the working channel of a flexible nasopharyngoscope could be applied with an endoscopic injection apparatus (Model NM-101C-0427 Olympus, Aomori, Japan. ), which includes a reusable metallic external sheath (MAJ-655) and a disposable flexible needle tract with a 27G rigid tip (MAJ-656).…”

Is Acupuncture Efficacious for Treating Phonotraumatic Vocal Pathologies? A Randomized Control Trial

“…Some of the most common causes of dysphonia include vocal nodules, polyps or chronic (or non-infectious) laryngitis 5,6 . Contemporary treatment recommendations include behavioral voice therapy that aims to re-adjust voicing mechanics and allows the vocal pathologies to resolve through a wound healing process is the current treatment option 7,8 . Surgery may be needed in some recalcitrant cases 9-11 but follow-up behavioral voice therapy 12,13 is required.…”