Comparison of bioaccessibility of astaxanthin encapsulated in starch-based double emulsion with different structures

Yang, Jie; Hua, Shuxian; Huang, Zehao; Gu, Zhengbiao; Cheng, Li; Yan, Hong

doi:10.1016/j.carbpol.2021.118475

Cited by 32 publications

(15 citation statements)

References 43 publications

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“…Astaxanthin (C 40 H 52 O 4 , 3,3-dihydroxy-β,β-carotene-4,4-dione), an orange-reddish-colored pigment, is widely distributed among the seafood byproducts, so it is often called marine carotenoid [ 41 , 42 ]. Structurally, it is a ketocarotenoid from the group of xanthophylls [ 7 , 43 ], with hydroxyl (OH) and keto (CO) groups at each terminal. This unique chemical structure is responsible for its characteristics and functions ( Figure 1 ) [ 7 , 44 ].…”

Section: Carotenoids From Crustaceansmentioning

confidence: 99%

“…Several studies have also reported their interactions forming lipoproteins and carotenoproteins [ 41 , 52 ]. Besides, a recent study by Yang et al [ 43 ] suggested that encapsulation of astaxanthin (in the starch-based emulsion) imparted its stability and increased accessibility. The bioaccessibility of astaxanthin was found to increase from 50 to 100% by encapsulation in gelatin gel [ 53 ], imparting its stability for inclusion in food supplements or matrices.…”

Section: Carotenoids From Crustaceansmentioning

confidence: 99%

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Astaxanthin from Crustaceans and Their Byproducts: A Bioactive Metabolite Candidate for Therapeutic Application

et al. 2022

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In recent years, the food, pharma, and cosmetic industries have shown considerable interest in bioactive molecules of marine origin that show high potential for application as nutraceuticals and therapeutic agents. Astaxanthin, a lipid-soluble and orange-reddish-colored carotenoid pigment, is one of the most investigated pigments. Natural astaxanthin is mainly produced from microalgae, and it shows much stronger antioxidant properties than its synthetic counterpart. This paper aims to summarize and discuss the important aspects and recent findings associated with the possible use of crustacean byproducts as a source of astaxanthin. In the last five years of research on the crustaceans and their byproducts as a source of natural astaxanthin, there are many new findings regarding the astaxanthin content in different species and new green extraction protocols for its extraction. However, there is a lack of information on the amounts of astaxanthin currently obtained from the byproducts as well as on the cost-effectiveness of the astaxanthin production from the byproducts. Improvement in these areas would most certainly contribute to the reduction of waste and reuse in the crustacean processing industry. Successful exploitation of byproducts for recovery of this valuable compound would have both environmental and social benefits. Finally, astaxanthin’s strong biological activity and prominent health benefits have been discussed in the paper.

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Section: Carotenoids From Crustaceansmentioning

confidence: 99%

Section: Carotenoids From Crustaceansmentioning

confidence: 99%

Astaxanthin from Crustaceans and Their Byproducts: A Bioactive Metabolite Candidate for Therapeutic Application

et al. 2022

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“…and Soneda, respectively [ 193 , 194 ]. In addition, due to its highly unsaturated molecular structure, ASX has reduced chemical stability during processing, storage, and digestion, being easily degraded in both acidic and alkaline environments and also under UV light, oxygen, or heat action [ 55 , 195 , 196 ]. The bioavailability of ASX has been reported to be increased in humans by its incorporation into lipid formulations of various compositions, and this may be due to the presence of conjugated bile salt and its ability to form bile salt micelles [ 189 ].…”

Section: Nutraceuticalsmentioning

confidence: 99%

“…In order to improve the water solubility, stability, and bioavailability of ASX, several delivery systems have been developed, such as complex coacervation, liposomes, emulsions and nanoemulsions, microparticles, and polymeric nanoparticles [ 196 , 198 , 199 ]. Since lipid-based nanoparticles, such as liposomes, solid-lipid nanoparticles, and niosomes have limitations, such as poor water solubility and permeability, instability, rapid metabolism, and poor oral bioavailability, polymeric nanoparticles have begun to be used to overcome these limitations.…”

Section: Nutraceuticalsmentioning

confidence: 99%

The Anticancer Potential of Plant-Derived Nutraceuticals via the Modulation of Gene Expression

Vranceanu

Galimberti

Banc

et al. 2022

Plants

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Current studies show that approximately one-third of all cancer-related deaths are linked to diet and several cancer forms are preventable with balanced nutrition, due to dietary compounds being able to reverse epigenetic abnormalities. An appropriate diet in cancer patients can lead to changes in gene expression and enhance the efficacy of therapy. It has been demonstrated that nutraceuticals can act as powerful antioxidants at the cellular level as well as anticarcinogenic agents. This review is focused on the best studies on worldwide-available plant-derived nutraceuticals: curcumin, resveratrol, sulforaphane, indole-3-carbinol, quercetin, astaxanthin, epigallocatechin-3-gallate, and lycopene. These compounds have an enhanced effect on epigenetic changes such as histone modification via HDAC (histone deacetylase), HAT (histone acetyltransferase) inhibition, DNMT (DNA methyltransferase) inhibition, and non-coding RNA expression. All of these nutraceuticals are reported to positively modulate the epigenome, reducing cancer incidence. Furthermore, the current review addresses the issue of the low bioavailability of nutraceuticals and how to overcome the drawbacks related to their oral administration. Understanding the mechanisms by which nutraceuticals influence gene expression will allow their incorporation into an “epigenetic diet” that could be further capitalized on in the therapy of cancer.

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“…Given that FFA promoted the formation of mixed micelles and the micelles could be used to solubilize astaxanthin, the release of astaxanthin could be regulated through the controlled lipolysis of oleogel-based nanoemulsions [48]. The structural destruction of oleogel-based nanoemulsions led to the exposure of the astaxanthin hydrophobic core, thereby contributing to the transfer of astaxanthin into the mixed micelles and improving astaxanthin bioaccessibility [49]. In addition, contrary to an inhomogeneous appearance of OGM-stabilized nanoemulsions, the OGC-stabilized nanoemulsion was homogeneous on the whole.…”

Section: Lipolysis and Bioaccessibility Of Astaxanthin In Oleogel-bas...mentioning

confidence: 99%

Modulation of Fabrication and Nutraceutical Delivery Performance of Ovalbumin-Stabilized Oleogel-Based Nanoemulsions via Complexation with Gum Arabic

Gao

Wang

Xue

et al. 2022

Foods

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Protein–polysaccharide complexes, which involve Maillard-type protein–polysaccharide conjugates and electrostatic protein–polysaccharide complexes, have the potential to stabilize oleogel-based nanoemulsions for nutraceutical delivery. Here, ovalbumin (OVA) and gum arabic (GA) were used to prepare OVA–GA conjugate (OGC) and OVA–GA mixture (OGM), followed by the fabrication of astaxanthin-loaded oleogel-based nanoemulsions. Carnauba wax (5% w/w) and rice bran oil were mixed to prepare food-grade oleogel. The successful preparation of OGC was verified by means of SDS-PAGE analysis and free amino groups determination. OGC endowed oleogel-based nanoemulsions with smaller emulsion droplets and higher stability during 30-day storage, implying more outstanding emulsifying capability than OGM. Both OGC-stabilized nanoemulsions and OGM-stabilized nanoemulsions could enhance the extent of lipolysis and the bioaccessibility of astaxanthin compared with oleogel. Meanwhile, OGC exhibited significantly better than OGM, which indicated that OGC-stabilized oleogel-based nanoemulsions possessed more desirable nutraceutical delivery performance than OGM-stabilized oleogel-based nanoemulsions. This study may fill a gap in the influence of different protein–polysaccharide complexes on oleogel-based nanoemulsions and contribute to deeper insights about novel oleogel-based nanoemulsions for their applications in the food industry.

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Comparison of bioaccessibility of astaxanthin encapsulated in starch-based double emulsion with different structures

Cited by 32 publications

References 43 publications

Astaxanthin from Crustaceans and Their Byproducts: A Bioactive Metabolite Candidate for Therapeutic Application

Astaxanthin from Crustaceans and Their Byproducts: A Bioactive Metabolite Candidate for Therapeutic Application

The Anticancer Potential of Plant-Derived Nutraceuticals via the Modulation of Gene Expression

Modulation of Fabrication and Nutraceutical Delivery Performance of Ovalbumin-Stabilized Oleogel-Based Nanoemulsions via Complexation with Gum Arabic

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