Comparison of Biochemical Relapse-Free Survival Between Primary Gleason Score 3 and Primary Gleason Score 4 for Biopsy Gleason Score 7 Prostate Cancer

Biochemical outcomes for patients with intermediate risk prostate cancer treated with I-125 interstitial brachytherapy monotherapy

“…Heavy percentage/total core involvement, were likely to have been influencing factors but we have not been able to analyse this further. We were unable to demonstrate a worse outcome in primary Gleason score 4 versus 3 in Gleason 7 disease which has been shown in some reports to be a useful prognostic indicator [46,47] but not in others [15,48]. This may well be due to the low number of GS 4 + 3 patients (n = 72), which suggests some level of selection by treating clinicians.…”

Brachytherapy Improves Biochemical Failure–Free Survival in Low- and Intermediate-Risk Prostate Cancer Compared With Conventionally Fractionated External Beam Radiation Therapy: A Propensity Score Matched Analysis

“…The rapid adoption of new RT practices as well as patient preference toward more convenient BT treatments are proposed explanations for the lack of comparative RT trials (13). A large number of retrospective studies have attempted to compare the treatment effectiveness of 2 or more RT modalities (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). However, interpretation of this retrospective evidence can be challenging because very few studies make direct comparisons in homogenous GUROC low-or intermediate-risk patient populations.…”

Primary Gleason pattern in biopsy Gleason score 7 is predictive of adverse histopathological features and biochemical failure following radical prostatectomy

“…Only a few studies conducted on biopsy specimens have been dedicated to this subject, and whether it is meaningful to stratify GS 7 according to the primary Gleason pattern in biopsies is somewhat controversial. Studies conducted before the ISUP 2005 modification have reported varying results regarding the association between the primary Gleason pattern and histopathological outcome and biochemical failure [11][12][13]20,21]. The grade migration caused by the Gleason grading system modification emphasizes the need for updated reports on the prognostic value of the primary Gleason pattern in biopsy GS 7 patients.…”

“…Only a few studies have assessed the association between the primary Gleason pattern in biopsy GS 7 and the RP specimen histopathology and risk of biochemical failure [10][11][12][13]. Results from these studies are conflicting, and most studies were conducted before the modified Gleason grading system established in 2005 by the International Society of Urological Pathology (ISUP) [14].…”