Comparison of Biological Activities of Ethanol Extracts of Unripe Fruit of Bitter Melon (Momordica charantia L.) Cultivated in Hamyang, Korea

문정한,; 최동원,; 김성은,; 서문지훈,; 홍수영,; 김현규,; 조계만,; 송진,; 강상수,; 김강화,; 권오경,

doi:10.3746/jkfn.2015.44.11.1637

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…Among the several extraction methods, ethanol extraction improved the highest inhibitory activities of α-glucosidase and pancreatic lipase of BME (Moon et al, 2015). In many studies, BME has been reported to have anti-obesity effects in both rodents and humans.…”

Section: Discussionmentioning

confidence: 99%

Anti-obesity Activity of Ethanol Extract from Bitter Melon in Mice Fed High-Fat Diet

et al. 2019

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In many cases, obesity is associated with metabolic disorders. Recently, natural compounds that may be beneficial for improving obesity have received increasing attention. Bitter melon has received attention as a diabetes treatment. NAD + -dependent deacetylase (Sirtuin 1, SIRT1) has emerged as a novel therapeutic target for metabolic diseases. In this study, ethanol extract of bitter melon (BME) suppressed adipocyte differentiation and significantly increased the expression of SIRT1 in fully differentiated 3T3-L1 cells. Moreover, it enhanced the activation of AMP-activated protein kinase (AMPK). In high-fat diet (HFD)-fed induced-obesity mice, BME suppressed HFD-induced increases in body weight and white adipose tissue (WAT) weight. BME also increased the expression of SIRT1 and suppressed peroxisome proliferator-activated receptor and sterol regulatory element binding protein 1 expressions of WAT from HFD-fed mice. These findings suggest that BME prevents obesity by activating the SIRT1 and AMPK pathway and that it may be a useful dietary supplement for preventing obesity.

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Section: Discussionmentioning

confidence: 99%

Anti-obesity Activity of Ethanol Extract from Bitter Melon in Mice Fed High-Fat Diet

et al. 2019

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“…Kolmar BNH (Sejong, Korea) prepared BME supplements, a product named “SugarKatcher S52.” The dried unripe bitter gourd was extracted with 70% ethanol at 70 °C, the conditions at which BME showed the highest antioxidant power as well as α-glucosidase and pancreatic lipase inhibition activities; subsequently, it was spray-dried for powder preparation. At this condition, the concentrations of total polyphenol and total flavonoid were the highest, as represented by gallic acid (7.66 mg/g) and tannin acid (7.77 mg/g; Moon et al, 2015 ); another index component—γ-aminobutyric acid (GABA)—1.08 mg/g (Lee et al, 2018 ). Cellulose, maltodextrin, hydroxypropyl methylcellulose, and a pigment matching the BME dose were the main contents of the placebo tablets.…”

Section: Methodsmentioning

confidence: 99%

Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study

Kim

Lee

Kim

et al. 2022

Food Sci Biotechnol

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This study was performed to investigate the effects of bitter melon extract (BME) on glucose metabolism, insulin resistance, and various metabolic parameters of participants with prediabetes. A 12-week randomized placebo-controlled clinical study was conducted with prediabetic patients. A total of 76 participants were randomly assigned to initiate the study. In the final analysis, 33 and 32 subjects were included in the BME and placebo groups, respectively. Results showed that 75 g oral glucose tolerance test (OGTT) blood glucose level decreased in BME group after 12 weeks. The glucose level after 30 min of glucose ingestion decreased significantly. The glucagon level in the BME group after 12 weeks significantly decreased 120 min after 75 g OGTT. These results suggested that bitter melon exhibits glucose-lowering effects through suppression of glucagon levels in people with prediabetes.

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“…In another study conducted in Korea, hydroxyl radical scavenger, ABTS and FRAP tests were used to determine the antioxidant activity of the plant sample. It has been reported that the best result was obtained from the hydroxyl scavenging test [27]. In another study conducted in Malaysia, DPPH and iron reduction test were used and it was reported that the plant has antioxidant potential [28].…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…It has been reported in the literature that extract obtained from M. charantia has anthelmintic effect against Caenorhabditis elegans at 500 µg/mL and antiviral effect against Herpes simplex type 1 viruses [14]. In a different study, it was reported to have an antidiabetic effect by inhibiting α-amylase, α-glucosidase and pancreatic lipase [21,27,31]. In another study, it was reported that M. charantia inhibited inflammatory nitric oxide and inhibited hydrogen peroxide induced DNA damage [22].…”

Section: Other Activitiesmentioning

confidence: 99%

Functıonal food Momordıca charantıa: bıologıcal actıvıtıes

Mohammed¹,

Uysal²,

Sevindik³

2023

Prosp. Pharm. Sc.

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Complementary medicine history includes a lot of knowledge based on human history. In this context, different plant species are used in the treatment and prevention of diseases. Plants are important natural productsthat attract attention with their nutritive and non-nutritive compounds. They contain many bioactive compounds that are not particularly nutritious but very important from a medical point of view. In our study, the biological activities of Momordica charantia reported in the literature were compiled. In addition, mineral, nutrient and chemical contents reported in the literature were compiled. The fruits of M. charantia are known as bitter gourd. In different parts of the world, it is used for many purposes as salad, direct food product, dried and spiced. It is used locally for different purposes in different countries. It is used as a supplement or sweetener in many foods, especially in East Asian countries. In our study, in addition to the nutritional properties of the plant, its medicinal properties were emphasized. As a result of the research, it was determined that the plant has many biological activities such as antioxidant, antimicrobial, antiinflammatory, antihyperglycemic, antiulcer, DNA protective, cytotoxic, anthelmintic, antiepimastigote, antiviral, immunomodulative, radioprotective, hepatoprotective, antidiabetes, antitumor, antiproliferative, antistress, hypoglycaemic, antimutagenic, or antiaging. In addition, it stands out with its nutritional properties. It is thought that it may be a natural source for the compounds reported in the literature data. Based on these studies, it is thought that Momordica charantia may be an important natural agent.

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Comparison of Biological Activities of Ethanol Extracts of Unripe Fruit of Bitter Melon (Momordica charantia L.) Cultivated in Hamyang, Korea

Cited by 5 publications

References 21 publications

Anti-obesity Activity of Ethanol Extract from Bitter Melon in Mice Fed High-Fat Diet

Anti-obesity Activity of Ethanol Extract from Bitter Melon in Mice Fed High-Fat Diet

Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study

Functıonal food Momordıca charantıa: bıologıcal actıvıtıes

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