Comparison of biological activity induced by Ailanthus altissima plant or cell cultures extracts

Perellino, Nicoletta Crespi; Guicciardi, A.; Minghetti, A.; Speroni, Ester

doi:10.1016/s0031-6989(88)80838-5

Cited by 12 publications

(6 citation statements)

References 3 publications

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“…Extracts of the plant leaves have demonstrated antiproliferative (De Feo et al. 2005), central nervous depressant (Crespi‐Perellino et al. 1988), antifeedant and insecticide (Kraus et al.…”

Section: Introductionmentioning

confidence: 99%

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ANTIBACTERIAL AND ANTIOXIDANT PROPERTIES OF AILANTHUS ALTISSIMA SWINGLE LEAVE EXTRACT TO REDUCE FOODBORNE PATHOGENS AND SPOILING BACTERIA

Rahman

Kim

Kang

2009

Journal of Food Safety

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The antibacterial and antioxidant potentials of methanolic extracts of Ailanthus altissima Swingle leaves were evaluated. Antibacterial activity was tested in vitro by agar disk diffusion method against 11 (six gram‐positive and five gram‐negative) foodborne bacteria. The methanol extract and its different polar subfractions inhibited significantly the growth of all six gram‐positive bacteria: Listeria monocytogenes (ATCC 19116, ATCC 19118 and ATCC 19166), Staphylococcus aureus (ATCC 6538 and KCTC 1916) and Bacillus subtilis ATCC 6633 and two gram‐negative bacteria: Pseudomonas aeruginosa KCTC 2004 and Escherichia coli ATCC 8739. The zones of inhibition of methanol extract and its derived different polar subfractions against the tested bacteria were found in the 12.1–23.2 mm range and the minimum inhibitory concentration values were recorded between 62.5 and 500 µg/mL. Antioxidant activity was evaluated by using 1,1‐diphenyl‐2‐picrylhydrazyl assay. The free radical scavenging activity of ethyl acetate (EtOAc) fraction was superior to all other fractions (IC50 = 16.45 µg/mL) and was higher than synthetic antioxidant butylated hydroxyanisole (IC50 = 18.27 µg/mL). Furthermore, the amount of total phenolic compounds was determined and its content in EtOAc fraction (12.25%) was the highest compared with other extract or fractions. PRACTICAL APPLICATIONS The natural products derived from Ailanthus altissima Swingle may contribute to the development of new antimicrobial agents with potential applications in food industries as natural preservatives or flavoring agents to control foodborne pathogens. They can be used as growth inhibitors of Listeria monocytogenes, Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa, as well as some important foodborne pathogens and spoiling bacteria. The main reason for their suitability is their natural origin, which consumers find comforting and is beneficial for the environment, and the very low risk that pathogens will develop resistance to the mixture of components that make up the extracts with their apparent diversity of antibacterial mechanisms. These beneficial characteristics could increase food safety and shelf life.

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Section: Introductionmentioning

confidence: 99%

“…Extracts of the plant leaves have demonstrated antiproliferative (De Feo et al 2005), central nervous depressant (Crespi-Perellino et al 1988), antifeedant and insecticide (Kraus et al 1994) activities. Fruit extracts of A. altissima Swingle occurring in China have shown antibacterial properties (Zhao et al 2005).…”

Section: Introductionmentioning

confidence: 99%

ANTIBACTERIAL AND ANTIOXIDANT PROPERTIES OF AILANTHUS ALTISSIMA SWINGLE LEAVE EXTRACT TO REDUCE FOODBORNE PATHOGENS AND SPOILING BACTERIA

Rahman

Kim

Kang

2009

Journal of Food Safety

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“…A. altissima has been used in Chinese traditional medicine as a bitter aromatic drug for the treatment of colds and gastric diseases (Feo et al, 2003;. Some compounds isolated from the root and bark of the plant have been reported to have insecticidal (Kraus et al, 1994), antimalarial (O'Neill et al, 1986;Bray et al, 1987), antitumor (Casinovi et al, 1983), antitubercular (Rahman et al, 1997), nervous depressant (Crespi-Perellino et al, 1988), antiproliferative (Hwang et al, 2002), anti-Epstein-Barr virus (Kubota et al, 1997), alleropathy (Heisey et al, 1990;1996), anti-inflammatory (Jin et al, 2009), and antioxidant activities (Okunade et al, 2003;Lee et al, 2005;Tamura et al, 2006;Zhang et al, 2007;Rahman et al, 2009). There have been some reports on the isolation of secondary metabolites from the cortex and roots of A. altissima.…”

Section: Introductionmentioning

confidence: 99%

Flavonoids from the Leaves of Ailanthus altissima Swingle and their Antioxidant Activity

Lee¹,

Kim²,

Park³

et al. 2013

Journal of Applied Biological Chemistry

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Phytochemical studies on the leaves of Ailanthus altissima (Simaroubaceae) have not been reported previously. Thus, the authors isolated and identified secondary metabolites from A. altissima. Dried and powdered leaves were extracted with 80% aqueous methanol, and the concentrated extract was successively partitioned with ethyl acetate, n-butanol, and water. Four flavonoids were isolated from the ethyl acetate fraction through repeated silica gel and octadecyl silica gel column chromatography. Spectroscopic data including NMR, MS, and IR allowed for identification of the chemical structures as quercetin (1), afzelin (2), quercitrin (3), and isoquercitrin (4). This is the first report of the isolation of these compounds from A. altissima. The four isolated flavonoids 1-4 as well as solvent fractions (ethyl acetate, n-butanol, and water), were evaluated for DPPH radical scavenging activity.

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“…Extract of A. altissima, has demonstrated anti-proliferative and central nerve depressant activities (O'Neill et al, 1986;Crespi Perellino et al, 1988;De Feo et al, 2005). Among the bioactive compounds isolated from A. altissima, quassinoids have various biological activities such as anti-tumor, anti-viral, anti-tuberculosis and anti-plasmodial activities (Kubota et al, 1997;Ohno et al, 1997;Rahman et al, 1997;Tamura et al, 2002;Okunade et al, 2003;Tamura et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Compounds from the Leaves of Ailanthus altissima Meihua JIN

Jin¹,

Bae²,

Chang³

et al. 2009

Biomolecules and Therapeutics

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-In our ongoing search for biological components from the Korea endemic plants, the MeOH extract of Ailanthus altissima leaves (Simaroubaceae) showed cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) dual inhibitory activity by assessing their effects on the production of prostaglandin D 2 (PGD2) and leukotriene C4 (LTC4) in mouse bone marrow-derived mast cells (BMMCs). In further study, eight compounds, squalene (1), β-sitosterol (2), scopoletin (3), quercetin (4), luteolin (5), astragalin (6), scopolin (7), and daucosterol (8) were isolated, the chemical structures were elucidated on the basis of physicochemical and spectroscopic data and by comparison with those of published literatures. Among the compounds, 2, 4, and 5 strongly inhibited both the COX-2-dependent PGD2 generation with IC50 values of 2.6, 7.3 and 2.5 μM, respectively and the generation of LTC 4 in the 5-LOX dependent phase with IC 50 values of 2.0, 5.1 and 1.8 μM, respectively, which suggest that the anti-inflammatory activity of A. altissima might occur in part via the inhibition of both PGD2 and LTC4 generation by 2, 4 and 5.

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Comparison of biological activity induced by Ailanthus altissima plant or cell cultures extracts

Cited by 12 publications

References 3 publications

ANTIBACTERIAL AND ANTIOXIDANT PROPERTIES OF AILANTHUS ALTISSIMA SWINGLE LEAVE EXTRACT TO REDUCE FOODBORNE PATHOGENS AND SPOILING BACTERIA

ANTIBACTERIAL AND ANTIOXIDANT PROPERTIES OF AILANTHUS ALTISSIMA SWINGLE LEAVE EXTRACT TO REDUCE FOODBORNE PATHOGENS AND SPOILING BACTERIA

Flavonoids from the Leaves of Ailanthus altissima Swingle and their Antioxidant Activity

Anti-inflammatory Compounds from the Leaves of Ailanthus altissima Meihua JIN

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