Comparison of biomechanical and structural properties between human aortic and pulmonary valve*1

Stradiņš, Pēteris; Lācis, Romāns; Ozolanta, Iveta; Purina, Biruta; Ose, Velta; Feldmane, Laila; Kasyanov, Vladimir

doi:10.1016/j.ejcts.2004.05.043

Cited by 144 publications

(81 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mechanical behavior of the dynamically conditioned tissue-engineered valve leaflets, in terms of the shape of the stress-strain curve, matched those of their native counterparts in radial direction, whereas in circumferential direction the engineered leaflet properties were lower (Figure 4, native valve data kindly provided by P. Stradins 18 ).…”

Section: Comparison Of Tissue-engineered Valves To Native Human Aortimentioning

confidence: 92%

Autologous Human Tissue-Engineered Heart Valves

et al. 2006

View full text Add to dashboard Cite

Background-Tissue engineering represents a promising approach for the development of living heart valve replacements.In vivo animal studies of tissue-engineered autologous heart valves have focused on pulmonary valve replacements, leaving the challenge to tissue engineer heart valves suitable for systemic application using human cells. Methods and Results-Tissue-engineered human heart valves were analyzed up to 4 weeks and conditioning using bioreactors was compared with static culturing. Tissue formation and mechanical properties increased with time and when using conditioning.

show abstract

Section: Comparison Of Tissue-engineered Valves To Native Human Aortimentioning

confidence: 92%

Autologous Human Tissue-Engineered Heart Valves

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Native aortic valve cusps are an anisotropic material with differing mechanical properties in the radial and circumferential directions. Which are determined by collagen fibers predominantly aligned and forming bundles in circumferential direction, whereas elastin fibers are orientated mainly in a perpendicular -radial direction [4].…”

Section: Introductionmentioning

confidence: 99%

Search for Electrospun Nanofiber Materials Matching The Mechanical Properties of Native Aortic Valve

Kalējs¹,

Stradiņš²,

Lācis³

et al. 2013

IJMMM

View full text Add to dashboard Cite

Abstract-Porous electrospun nanofiber materials are very promising as matrixes for heart valve tissue engineering. The perfect material for this purpose has to be both mechanically strong and deformable at the same time.Materials from gelatin, polyurethane (PUR), polylactic acid (PLA) and polycaprolactone (PCL) made in several density variants were analyzed using uniaxial tensile tests and compared to mechanical properties of porcine aortic valve (AV) leaflets in radial and circumferential directions.In circumferential direction modulus of elasticity (E) of AV is 9.7±1.3MPa and -1.0±0.2MPa in radial. Ultimate strain and stress is 44.8±5.9% and 2.3±0.6MPa in circumferential and 95.6±31.4% and 0.5±0.2MPa in radial direction for AV. Closest of the materials to native AV in circumferential direction was PUR with area density 6.2 g/m 2 showing E of 3.9±0.5 MPa, ultimate stress and strain -5.3±1.68MPa and 141.8±43.9% respectively. Closest to radial direction was gelatin with area density 5.7 g/m 2 showing E of 0.64±0.14 MPa, ultimate stress and strain -0.38±0.05MPa and 82.53±10.20% respectively.Native AV leaflets have a non-linear and anisotropic response to stress in uniaxial tensile tests. To model their mechanical properties we suggest using a combined material made of gelatin and PUR with their fibbers predominantly orientated in perpendicular directions.

show abstract

“…1.74 ± 0.29 15.53 ± 3.84 [78] Bovine pericardium 3.8 ± 1.2 (SD) 21.7 ± 11.7 (SD) [79] Bovine pericardium 25 ± 10 (SD) 190 ± 50 (SD) [69] Porcine pericardium 12 ± 2 (SD) 110 ± 10 (SD) [69] …”

mentioning

confidence: 99%