Comparison of birth weight corrected for gestational age and birth weight alone in prediction of development of childhood leukemia and central nervous system tumors

Sprehe, Michael; Barahmani, Nadia; Cao, Yumei; Wang, Tao; Forman, Michéle R.; Bondy, Melissa L.; Okcu, M. Fatih

doi:10.1002/pbc.22308

Cited by 49 publications

(76 citation statements)

References 32 publications

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“…[15] Birth weight-for-gestational age was constructed using U.S. national reference for fetal growth and was classified into three categories: small-for-gestational age (SGA), average-for-gestational age (AGA) and large-forgestational age (LGA). [22] To evaluate dose-response relationships between birth weight and childhood leukemia we obtained odds ratios using a moving window of birth weight.…”

Section: Methodsmentioning

confidence: 99%

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Birth weight and other perinatal characteristics and childhood leukemia in California

Oksuzyan

Crespi

Cockburn

et al. 2012

Cancer Epidemiology

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Aims We conducted a large registry-based study in California to investigate the association of perinatal factors and childhood leukemia with analysis of two major subtypes, acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML). Methods We linked California cancer and birth registries to obtain information on 5788 cases and 5788 controls matched on age and sex (1:1). We examined the association of birth weight, gestational age, birth and pregnancy order, parental ages, and specific conditions during pregnancy and risk of total leukemia, ALL and AML using conditional logistic regression, with adjustment for potential confounders. Results The odds ratio (OR) per 1000 gram increase in birth weight was 1.11 for both total leukemia and ALL. The OR were highest for babies weighing ≥4,500g with reference <2,500g: 1.59 (95% CI: 1.05-2.40) and 1.70 (95% CI: 1.08-2.68) for total leukemia and ALL, respectively. For AML, increase in risk was also observed but the estimate was imprecise due to small numbers. Compared to average-for-gestational age (AGA), large-for-gestational age (LGA) babies were at slightly increased risk of total childhood leukemia (OR=1.10) and both ALL and AML (OR=1.07 and OR=1.13, respectively) but estimates were imprecise. Being small-forgestational age (SGA) was associated with reduced risk of childhood leukemia (OR=0.81, 95% CI: 0.67-0.97) and ALL (OR=0.77, 95% CI: 0.63-0.94), but not AML. Being first-born was associated with decreased risk of AML only (OR=0.70; 95% CI: 0.53-0.93). Compared to children with paternal age <25 years, children with paternal age between 35 and 45 years were at increased risk of total childhood leukemia (OR=1.12; 95% CI: 1.04-1.40) and ALL (OR=1.23; 95% CI: 1.04-1.47). None of conditions during pregnancy examined or maternal age were associated with increased risk of childhood leukemia or its subtypes. Conclusions Our results suggest that high birth weight and LGA were associated with increased risk and SGA with decreased risk of total childhood leukemia and ALL, being first-born was associated with decreased risk of AML, and advanced paternal age was associated with increased risk of ALL. These findings suggest that associations of childhood leukemia and perinatal factors depend highly on subtype of leukemia.

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Section: Methodsmentioning

confidence: 99%

“…Of those that did, most showed that large-for-gestational age babies were at increased risk of childhood leukemia. [12, 15]…”

Section: Introductionmentioning

confidence: 99%

Birth weight and other perinatal characteristics and childhood leukemia in California

Oksuzyan

Crespi

Cockburn

et al. 2012

Cancer Epidemiology

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“…Although previous studies have shown that children born with a high birth weight had an elevated risk of brain tumors (1)(2)(3)(4), others have found no association (5)(6)(7)(8). Moreover, it has been reported that children born with a large head circumference had a higher risk of brain tumors (4,9,10), particularly in the first year of life (4,10).…”

Section: Introductionmentioning

confidence: 80%

“…The effect of birth size characteristics, such as birth weight, fetal growth, gestational age, and head circumference, on brain tumor risk has mainly been investigated among children (1)(2)(3)(4)(5)(6)(7)(8). Although previous studies have shown that children born with a high birth weight had an elevated risk of brain tumors (1)(2)(3)(4), others have found no association (5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 94%

“…If growth factors are involved in the process of brain tumor onconogenesis, it is, however, plausible that birth weight by gestational age is a more appropriate indicator of risk, as it has been shown for acute lymphoblastic leukemia (6). Therefore, studies have often reported results for both birth weight and birth weight by gestational age (4,6,10,12).…”

Section: Introductionmentioning

confidence: 99%

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Birth Size Characteristics and Risk of Brain Tumors in Early Adulthood: Results from a Swedish Cohort Study

Tettamanti

Ljung

Mathiesen

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Despite extensive research on the effect of birth size characteristics on childhood brain tumors, very few studies have evaluated the effect of birth size characteristics on the risk of adult brain tumor, and they have provided inconsistent results.Methods: All individuals born in Sweden between 1973 and 1995 who were still alive and cancer free at their 15th birthday were included in the study (n ¼ 2,032,727). At the end of the study period (December 31, 2010), the study participants were 15 to 37 years old. Incident cases of primary brain tumors were identified through the Swedish Cancer Register.Results: No association was observed between any birth size characteristics and glioma, although an indication of increased glioma risk associated with high birth weight, or being large for gestational age at birth, was found among men [relative risk

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A greater birthweight increases the risk of acute leukemias in Mexican children—experience from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia (MIGICCL)

et al. 2018

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In Mexico, due to the high rates of diabetes, overweight, and obesity, there has also been noted an increased newborn weight, which may be contributing to the elevated incidence rate of childhood acute leukemia (AL). We conducted a case–control study in public hospitals of Mexico City aimed to know whether a greater weight at birth is associated with a higher risk of developing leukemia. We included incident cases with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) diagnosed between 2010 and 2015. Controls were frequency‐matched to the cases by age, sex, and health institution. Logistic regression analysis was performed adjusting risks by child's sex, overcrowding index, birth order, and mother's age at the time of pregnancy. Adjusted odds ratios (aORs) and 95% confidence intervals were calculated. A total of 1455 cases and 1455 controls were included. An evident association between ALL and child's birthweight ≥2500 g was found (aOR 2.06; 95% CI: 1.59, 2.66) and also, in those with birthweight ≥3500 g (aOR 1.19; 95% CI: 1.00, 1.41). In AML patients with birthweight ≥2500 g and ≥3500 g, an aOR of 1.77 (95% CI: 1.07, 2.94) and 1.42 (95% CI: 1.03–1.95) was observed, respectively. No association was noticed with either type of AL and a birthweight ≥4000 g. To sum up, we found a moderate association between not having a low birthweight and an increased risk of acute leukemias. Birthweight ≥3500 g was also a risk factor for both types of leukemia. This suggests that a greater birthweight may increase the risk of acute leukemias in Mexican children.

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Comparison of birth weight corrected for gestational age and birth weight alone in prediction of development of childhood leukemia and central nervous system tumors

Cited by 49 publications

References 32 publications

Birth weight and other perinatal characteristics and childhood leukemia in California

Birth weight and other perinatal characteristics and childhood leukemia in California

Birth Size Characteristics and Risk of Brain Tumors in Early Adulthood: Results from a Swedish Cohort Study

A greater birthweight increases the risk of acute leukemias in Mexican children—experience from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia (MIGICCL)

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